by Anonymous Coward writes:
on Thursday January 13, 2005 @03:00PM (#11350993)
Im sure someone can further answer but I will answer what I can:
Acetylcholine is the base chemical that almost all the neurotransmitters are made from. NT's are what makes the brain function
Adrenaline makes you ready to fight or run. Accelerates your body
Dopamine is the pleasure transmitter I believe, or its a pain blocker. Gives your body the positive reward response. Cocaine's high is from exciting dopamine receptors
Endorphine is similar to dopamine, I think one of them is a pain blocker and the other is a reward.
Serotonin gives you your good mood. Ectacy users know all about this, that is what E does, it boost your seritonin levels through the roof.
Oxycotin, isn't a NT as far as I know, its a synthetic opiate. effects endorphine receptors?
Histamines I don't know how to describe, but allergic reactions release histamines in your body, that is the reaction.
Insulin, isn't an NT either, it burns sugar in your body.
My daughter's first complete phrase was: "Push the button, Frank." We told Trace Beaulieu about this at a convention a few years ago, and he turned to her and said with a voice of sympathy "I'm very sorry."
There is an absolutly hilarious news event which locks these two in my mind.
Some kids broke into a vet's office looking for the pain blocker and ended up with the hormone instead. Considering it induces breastfeeding responses, even in men, the results were rather humrous.:)
Oops! Thieves take wrong drug
Police say 4 men searching for 'Oxy' stole hormone used to induce labor.
By Diane Frederick
Indianapolis Star
August 25, 2001
NOBLESVILLE, Ind. -- Four men on a misguided quest for the heroinlike drug OxyContin instead scored the similar-sounding but pharmaceutically distinct oxytocin, authorities say.
Oxytocin is a hormone used to induce labor.
"I don't know if they used any," said Detective Todd Uhrick of the Hamilton
County Sheriff's Department. "They were all pretty dumb."
Hamilton County authorities Friday still were looking for the four men in connection with a series of thefts in recent months from veterinarian and dentist offices in five counties. Investigators said one of the men admitted to the misadventure while under interrogation for another crime.
The man admitted to his involvement in the burglary of a veterinary clinic in Sullivan, in southwestern Indiana, authorities said. He said he and his accomplices took liquid OxyContin, a prescription drug that produces an addictive high when the tablets are crushed and snorted or dissolved and injected.
But upon checking, investigators learned that the "Oxy' stolen in Sullivan County was oxytocin.
Charges in the drug theft are expected to be filed.
A Hamilton County court issued warrants for James D. Frye and Scott. A. Earlywine, both 19, of Noblesville; Rolla Kevin Thompson, 19, of Indianapolis; and Norman Keith Keel, 18, of Kokomo. All are charged with burglary and theft. Only Keel had been arrested as of Friday night.
The charges stem from the theft of guns from a veterinarian in Sheridan.
Uhrick said the men used the guns to try to shoot open a safe they had heisted from a veterinary clinic in Lapel.
After they failed, Uhrick said, they left the safe near White River. When they returned the next day, it was gone.
And my wife doesn't understand why I want to move from such a wonderful suburb of Noblesville to some place a little higher on the educational ladder. Say.... Kentucky, or Arkansas.
> Oxycontin (synthetic opiate) is a dangerous drug which has led to many deaths
Gee, seems pretty coincidental that it's a drug usually given to people... WHO ARE TERMINALLY ILL! Would you rather die flipped out of your mind on drugs or live an extra month in unbearable pain from an untreatable disease that's eating you alive?
And really, what a bunch of sensationalist tripe. 500 people... 500 PEOPLE. Less than two ten-thousandths of one percent of the U.S. population. Not exactly a leading cause of death. Nor would that be considered "many."
As an aside, the people who run that site act like each name reported comes from a desperate loved one of that person trying to "fight for the cause"... yet 80% of the one-liners are nearly IDENTICAL. They just googled for obituaries & news reports to get a long list of names.
I'm guessing that your wife was induced with Pitocin, which is synthetic oxytocin. The problem with that is that since the stuff was pumped into her, her body didn't have to produce it itself. If a woman goes into labor naturally the release of oxytocin triggers the release of other nifty hormones, including endorphins. If labor is induced, that doesn't really happen. The hormone balance is out of whack and she doesn't get the good stuff.
Plus, the dosage of Pitocin is often much higher than oxytocin l
"who gives Tylenol to someone alergic to acetomenophen?"
Probably the same doctor I had a few years back who was trying to write me a prescription for Penicillin while using my medical folder for a writing surface. A folder with a 4x4 inch red and white "ALLERGIC TO PENICILLIN" sticker on the front. No, the prescription pad wasn't covering the sticker, it was in plain sight. When I pointed it out to him (quite nicely I thought) he actually had the nerve to question whether I was really allergic or not. H
And this is some text for the lameness filter.
And this is some text for the lameness filter.
And this is some text for the lameness filter.
And this is some text for the lameness filter.
(Side note: Histamine and insulin are not neurotransmitters.)
Acetylcholine: What makes your enemies' muscles convulse so strongly they break their own bones to shreds when you hit 'em with acetylcholinesterase inhibitors. (Or when you nail those goddamn roaches with the bug spray, which is pretty much same thing.)
Adrenaline: What you secrete when you're trying to figure out what to do about the simultaneous appearance of a cloud of dense fog coming towards y
Neurotransmitters are chemicals which relay signals among neurons (and sometimes between neurons and other cells) in your body. There are gaps between neurons called synapses; these gaps are crossed by neurotransmitters. Many, but by no means all, are modified amino acids.
For this list:
Acetylcholine: The primary neurotransmitter of the parasympathetic nervous system- in other words, it transmits signals other than fight-or-flight type, and is necessary for normal cognitive function.
Adrenaline: Synthesized from the amino acid tyrosine, and released from the adrenal medulla, this NT takes care of sympathetic responses, the fight-or-flight stuff that jacks up your heart rate and mobilizes the body for action. Also known as epinephrine.
Dopamine: A few steps up in the synthesis ladder for adrenaline is this NT, which is involved in the brain's "reward system" and also in motor control- dopaminergic neurons are damaged in Parkinson's disease, leading to its characteristics.
Endorphin: Actually a group of compounds, endorphins are, as their name suggests, endogenous opioids, and are released in respone to pain. Responsible for "runner's high."
Serotonin: Also known as 5-HT, this neurotransmitter can have a powerful effect on mood and behavior. Antidepressants known as MAOIs inhibit the action of the enzyme monoamine oxidase which breaks serotonin down.
Oxytocin: A peptide hormone released by the pitutary gland, oxytocin is sometimes known as "the love hormone," because it is released during many mating/parental bonding type events.
Histamine: A substance made from the amino acid histidine, it helps regulate stomach acid secretion (it's one of the H's in H2 blocker drugs), but it better known for the powerful inflammatory response it causes in allergic reactions.
Insulin: Peptide hormone released by the pancreas in response to increased blodd glucose levels; has a variety of effects dealing with metabolism and energy use.
I know I'm not supposed to complain about poll options, but the poll leaves out some of my favorite NTs, like ATP, GABA, norepinephrine, and nitric oxide.
In addition to "runner's high", the primary purpose of endorphins is to quickly but temporarily eliminate pain so you can deal with the situation in the event of serious injury.
When I was hit by a car 2 years ago I didn't feel any pain for several minutes, despite having one hand dislocated off the end of my arm (which was also broken).
Dopamine: A few steps up in the synthesis ladder for adrenaline is this NT, which is involved in the brain's "reward system"
On the psychopharmacology side, cocaine and amphetamine are also agonists at dopamine receptors, so it's easy to see the connection to the "reward system".
Endorphin: Actually a group of compounds, endorphins are, as their name suggests, endogenous opioids, and are released in respone to pain. Responsible for "runner's high."
And of course, our favorite exogenous opiates of heroin, morphine, and opium have the same effect because they act on the same receptors!
Serotonin: Also known as 5-HT, this neurotransmitter can have a powerful effect on mood and behavior. Antidepressants known as MAOIs inhibit the action of the enzyme monoamine oxidase which breaks serotonin down.
Also, Prozac, Paxil, and Zoloft are reuptake inhibitors for serotonin, meaning that they cause the seratonin to be reabsorbed more slowly and make more of it available for neurotransmission. These antidepressants are thus known as serotonin-specific reuptake inhibitors, or SSRIs.
I know I'm not supposed to complain about poll options, but the poll leaves out some of my favorite NTs, like ATP, GABA, norepinephrine, and nitric oxide.
Don't forget glutamate, the major excitatory neurotransmitter in the CNS. My personal favorite NT is anandamide, which binds to the cannabinoid receptor and is one of the first known retrograde neurotransmitters.
There was nitric oxide in what I've submitted, but I wrote it as NO; most likely the "editors" did not understand what it meant and threw it out thinking it was a badly worded CowboyNeal option.
THC isn't, but it closely mimics anandamide! This is the substance for which our little thc brain receptors are built. In fact the endocannibinoids (internally produced cannibis like chemicals) are so extensive that current research regards them as a complete system likely involved with pain response and memory formation (or the suppression thereof).
Acetylcholine - first neurotransmitter discovered. Mediates muscle contraction, sweating and numerous other synapse actions. Adrenaline - fight or flight hormone, gets the body revved up to go. Dopamine - multi system regulation (heart, kidneys, brain, etc) Endorphin - opiod like chemical produced in brain...makes you feel good. Serotonin - modulates mood, sleep and emotion. Target for antidepressant meds. Oxytocin - causes milk "drop down" in breast feeding and mediates the labor process Histamine - causes the itching from an allergic reaction Insulin - controls uptake of sugar from the blood. No insulin = diabetes.
I also think it's interesting that some theories about how LSD does what it does is that it affects Serotonin reuptake in the brain.
Maybe thats why LSD my favorite drug.
I've found it interesting that the molecules of serotonin, psilocybin, mescaline, and LSD (less so), have similar chemical structures as seen here [bris.ac.uk]. What's also weird, is that these drugs are not what I call "feel good" drugs. They are psychedelics that are very tripped out, but I would not consider them antidepressants or anything like
Mescaline is pretty cool. Its a mellower than LSD. Similar visuals, but duller. You don't feel as crazy and witty on mescaline.
I've only done MDMA once, and I was also on 4 other drugs (weak LSD, alcohol, some mushrooms, & pot) so I can't isolate the effects totally, but I didn't care for it that much. I sweated profusely and felt speed up and "good". The majority of the high was from MDMA. It didn't seem to last that long. I did the "pure" powder form of MDMA often called "molly". YMMV.
I realize that slashdot readers might not be in this situation, but I'm sure your right (or left) hand may be sufficient for you to maximize your endorphin, uhhh, loading.
A damn charlie horse in the middle of the night. Truly a rude awakening. I blame only myself for not eating a banana yesterday, but it sucks to limp around on a sore calf. (In HS I'd get these all the time and frequently limp along on BOTH sore calves, before learning I needed more potassium.)
I used to get cramps in my calves while swimming, and he told me to eat a banana an hour or half hour before swimming. Sure enough, no more cramps.
That's because bananas are a good source of Potassium; lack of potassium and other electrolytes is the main cause of muscle cramps, not anything to do with neurotransmitters. Gatorade, vitamin pills do the same thing.
My swimming coach told us the same thing. When we would go to the invitational and big meets where we would stay in a hotel we always stayed at a place that had continental breakfasts so we could load up on bananas. We'd stuff them in the oversized front pocket of our team jackets. I think they made them big for just that reason. There was nothing worse that being half way down your lane and getting a cramp so bad you leg would bend all the way back and someone had to help you back the wall.
Definitely. Because not having enough of it makes your mind do things like wonder if your family would be better off just getting the life insurance money if you just drove your car into the next bridge pier.
Actually, when you're inhibiting reuptake of a neurotransmitter, it's because there's rarely enough in the synapse and is being reuptaken in the axon too quickly. Inhibit reuptake and the transmitter stays in the synapse longer.
That said, too much serotonin can cause problems of its own.
Perhaps that's what I was thinking of. HBO used to run a series called "Autopsy." Not too cheery, I'll admit, but I one point they were analyzing the seratonin levels in the brains of people that had killed themselves. Apparently the levels were through the roof.
Not that I have anything against it, and I even realize that it helps keep me alive by metabolizing my blood sugar....but let me elaborate:
I'm no biologist, but lately I've done a lot of reading up on weight loss techniques, and even tried (successfully) some of them. It turns out that in addition to lowering blood glucose levels, Insulin also triggers storage of dietary fat as body fat. This second property of Insulin (the first one is lowering blood sugar) is very often ignored/overlooked.
While I'd still vote for endorphins hands down, I thought it was unusual that insulin and oxytocin were included, but not GABA or monoamines.
GABA (gamma-aminobutyric acid): An inhibitory neurotransmitter that regulates Cl- and K+ cellular ion channels. In the brain, GABA works in the hippocampus and affects memory. The anxiolytic benzodiazepines (minor tranquilizers used in treating anxiety disorders) - including such drugs as diazepam (Valium), lorazepam (Ativan), clonazepam (Klonopin), flunitrazepam (Ro
Just a little FYI for those of you who miss the "glory days" of yard chemicals. Part of the reason that Organophosphates (Diazinon, Dursban, Lindane, Chlordane...) have been banned is because they are interfere with the cholinesterase enzyme and cause all sorts of problems. So while Diazinon and Dursban were perhaps some of the best controls for insects, they also had the ability to just nuke mamals, birds and other animal kind. The Germans in the WWI era, had a little fun -- they developed a couple well known organophosphates, like Tabun, Sarin, and Soman (all G chemicals) for the use in killing insects -- but it was discovered that they do a great job killing people too. The advantage to an organophosphate though, is that _generally_ they have short half-lives. Just about most organophospates for killing bugs are gone in about three days. The disadvantage is that they work on they interfer with the neurotransmitter process. Now they are being replaced by the pyrthriod class of chemicals for killing bugs (a pyrthrium is derived from juiced Marrygolds). The newer pyrthriods are capable of killing insects for anywhere from two weeks to six months, and relatively safe for use around humans. The biggest problem is that they are not intense enough to capture some friends like termites. An organophosphate was the equivalent of nuking the population of insects, but with pythriods, it kills the insects over a period of time. Okay, have to run now.
Histamines! Mean, nasty, hostile things! Most of my favorite drugs have been one or another anti-histamine (depending on whether I'm more or less willing to put up with side effects like drowsiness.) (Not all my favorites, of course - caffeine and cannabis are still nice drugs, and mild opiates are really good for dental pain, and penicillin is really good stuff.)
Histamines do have their uses - they seem to be part of the body's defense against problems like parasites that we don't have much of in Western Civilization, but boy it gets annoying to have my body launching an all-out war on tree-pollen, grass-pollen, ragweed, and various molds and yeasts.
Acetylcholine - primarily involving motor neurons transmitting signals to muscle for muscle contraction, and also involved in upper motor neurons for autonomic nervous system for control of blood pressure and heart rate.
Adrenaline - AKA epinephrine, primary involved in stress response and autonomic regulation of blood vessel tone and heart rate, also produced in adrenal glands for stress hormonal response, and your doctor's favorite drug of use emergency treatment of low blood pressure and ventricular fibrillation.
Dopamine - another catecholamine type neurotransmitter, involved in autonomic blood pressure regulation, low dose increase blood flow to kidney, wheras high dose will increase vascular tone and heart contractility.
Endorphine - a polypeptide neurotransmitter, involved in pain transmission and actually blocks transmission of pain signals to the brain. Also results in mild vasodilatation.
Serotonin - AKA 5-hydroxy-tryptamine, mostly found in central nervous transmission in brain, and involved in mood regulation; the theory goes low levels of serontonin activity results in depression. High levels can also lead to hallucinations as in LSD - a serotonin analogs. Most modern antidepressant drug, e.g. Prozac, Celexa, Sertraline, slow down the uptake of serotonin neurotransmitter from synaptic cleft to effectively raise serotonin levels.
Oxytocin - another polypeptic neurotransmitter, involved in neurotransmission of lactation - production of milk in mammary glands.
Histamine - not a catecholamine nor a polypeptide molecule. Involved in allergic response as in hayfever and asthma. Also involved in the gut nervous system in stimulating the production of hydrochloric acid in stomach causing heartburn, ulcers and aiding digestion of proteins.
Insulin - not really a neurotransmitter, mostly a hormone, produced in the beta islet cells of the pancreas and involved in the regulation of glucose uptake, production and storage. Lack of insulin production leads to Type I Diabetes mellitus, whereas Insulin resistance as in obesity leads to Type II Diabetes Mellitus. May also insulin receptors in brain regulating hunger. Counter-regulatory hormones include glucagon and growth hormone.
High levels can also lead to hallucinations as in LSD - a serotonin analogs
Not sure if parent's quote is accurate or not (IANAD), however I do know that LSD (and related psychadelics) do not cause hallucinations by raising the Serotonin level - what they do is mimic the chemcial structure of Serotonin, so receptors where it normally bonds to it cannot since LSD/Psilocybin/etc are taking it's place.
Now Serotonin is a deactivating neutrotransmitter, meaning it slows/stops the progression of chemical sign
As has been already mentioned serotonin regulates your mood and sleep, if you don't have enough you feel crappy and sleep erratically. I thoroughly recommend taking 5-HTP - this is the chemical that your body uses to create serotonin (5-HT), it has a very noticeable impact on mood and sleep. You can get it from any number of places online.
It also REALLY helps reduce the impact of serotonin depletion on your mood if you take ecstasy, take a couple of 5-HTP on your comedown and the "downer" is almost complet
The results of the poll (its early though) resemble a normal distribution curve. Coincidence? Did people really chose at random basically or were the most popular ones really in the middle?
From Gutierrez, M.A., et al., 1999. "Management of and Counseling for Psychotropic Drug-Induced Sexual Dysfunction" Pharmacotherapy 19(7):823-831:
"Although the effect of psychotropic drugs on various hormones is not certain, their effect on several neurotransmitters influencing sexual function is well established. Dopamine is the neurotransmitter in the mesolimbic "pleasure center." Increasing dopaminergic activity may enhance sexual response, and blocking it may compromise response."
I plan to use the results of this scientific poll of Slashdot readers in order to begin producing certain prescription-only, generic drugs to be sold at reduced cost through Canadian pharmacies. I have a lab, access to the proper chemicals/supplies, and three helpful graduate students. What I have been waiting for is this very poll to appear on Slashdot. Oh, thank you Slashdot Gods!
Well, jeez. Considering that glutamate and GABA are the two most important neurotransmitters for fast neuronal communication, their absence in this poll is astounding. Who came up with this poll?
Dimethyltryptamine [wikipedia.org](DMT). Gets released at birth and at death. It must have a important meaning to life but I'm not aware what it is. Its mystery makes it very interesting.
DMT is also created is you spend 21 days in total darkness. The early Christians and the Taoists use it to scrub the mind clean and open it to god. Risk Strassman thinks its a soul lubricant that allows for the soul to enter and leave the body. Biological explination for Near Death and Alien Abduction. Can be made from Reed's Canary grass as a free base salt. Used with a MOAI it is the basis for south american ethnogenic drugs like ayhuasca. May allow for limited telepathy or just heighentend awareness. Might be an explanation for enhanced senses for profoundly blind people. Might reiar long term brain damage from alcohol abuse. Good stuff. DON'T TAKE RECREATIONALLY.
I am the poll submitter, and I've submitted a significantly different set of options: I specifically did not include Endorphin because it would be the obvious choice, and there was no Insulin because it is rather a hormone.
I had instead NO (nitrous oxide) - the controversial one - and the CowboyNeal option "My nervous system is purely electrical". Why they had messed up with my poll is beyond me.
Well ya see, Norm, it's like this... A herd of buffalo can only move as fast as the slowest buffalo. And when the herd is hunted, it is the slowest and weakest ones at the back that are killed first. This natural selection is good for the herd as a whole, because the general speed and health of the whole group keeps improving by the regular killing of the weakest members.
In much the same way, the human brain can only operate as fast as the slowest brain cells. Excessive intake of alcohol, as we know, kills brain cells. But naturally, it attacks the slowest and weakest brain cells first. In this way, regular consumption of beer eliminates the weaker brain cells, making the brain a faster and more efficient machine. That's why you always feel smarter after a few beers.
More like, it saves countless lives everyday.
Doctors use them in shock patients to raise systemic blood pressure and preserve blood flow to important organs like your brain and heart.
In any formula, constants (especially those obtained from handbooks)
are to be treated as variables.
what do they do? (Score:2)
btw, frist psot
Re:what do they do? (Score:5, Informative)
Acetylcholine is the base chemical that almost all the neurotransmitters are made from. NT's are what makes the brain function
Adrenaline makes you ready to fight or run. Accelerates your body
Dopamine is the pleasure transmitter I believe, or its a pain blocker. Gives your body the positive reward response. Cocaine's high is from exciting dopamine receptors
Endorphine is similar to dopamine, I think one of them is a pain blocker and the other is a reward.
Serotonin gives you your good mood. Ectacy users know all about this, that is what E does, it boost your seritonin levels through the roof.
Oxycotin, isn't a NT as far as I know, its a synthetic opiate. effects endorphine receptors?
Histamines I don't know how to describe, but allergic reactions release histamines in your body, that is the reaction.
Insulin, isn't an NT either, it burns sugar in your body.
Re:what do they do? (Score:5, Informative)
Re:what do they do? (Score:4, Informative)
Re:what do they do? (Score:2)
Re:what do they do? (Score:5, Funny)
Oxytocin is good stuff. Without it my post-baby belly would never disappear!
Re:what do they do? (Score:5, Funny)
First words (Score:5, Funny)
"Push the button, Frank."
We told Trace Beaulieu about this at a convention a few years ago, and he turned to her and said with a voice of sympathy "I'm very sorry."
Oxytocin Not Oxycotin. (Score:4, Informative)
Re:Oxytocin Not Oxycotin. (Score:5, Funny)
Some kids broke into a vet's office looking for the pain blocker and ended up with the hormone instead. Considering it induces breastfeeding responses, even in men, the results were rather humrous.
Re:Oxytocin Not Oxycotin. (Score:2, Informative)
-Peter
Re:Oxytocin Not Oxycotin. (Score:4, Funny)
*hangs his head*
And my wife doesn't understand why I want to move from such a wonderful suburb of Noblesville to some place a little higher on the educational ladder. Say .... Kentucky, or Arkansas.
Re:Oxytocin Not Oxycotin. (Score:2, Informative)
Actually the drug is Oxycontin
Actually... (Score:4, Interesting)
The drug labeling information with all the technical stuff may be found here [fda.gov].
Re:Oxytocin Not Oxycotin. (Score:4, Insightful)
Gee, seems pretty coincidental that it's a drug usually given to people... WHO ARE TERMINALLY ILL! Would you rather die flipped out of your mind on drugs or live an extra month in unbearable pain from an untreatable disease that's eating you alive?
And really, what a bunch of sensationalist tripe. 500 people... 500 PEOPLE . Less than two ten-thousandths of one percent of the U.S. population. Not exactly a leading cause of death. Nor would that be considered "many."
As an aside, the people who run that site act like each name reported comes from a desperate loved one of that person trying to "fight for the cause"... yet 80% of the one-liners are nearly IDENTICAL. They just googled for obituaries & news reports to get a long list of names.
Re:oxytocin (Score:3, Interesting)
Plus, the dosage of Pitocin is often much higher than oxytocin l
Re:oxytocin (Score:3, Interesting)
Probably the same doctor I had a few years back who was trying to write me a prescription for Penicillin while using my medical folder for a writing surface. A folder with a 4x4 inch red and white "ALLERGIC TO PENICILLIN" sticker on the front. No, the prescription pad wasn't covering the sticker, it was in plain sight. When I pointed it out to him (quite nicely I thought) he actually had the nerve to question whether I was really allergic or not. H
Re:what do they do? (Score:2, Informative)
i mean - sure, testostorone can regulate some processes, but it isnt a neurotransmitter.
i (as a former biochemist) call bs on this entire poll
Re:what do they do? (Score:4, Informative)
Acetylcholine [wikipedia.org]
Adrenaline [wikipedia.org]
Dopamine [wikipedia.org]
Endorphine [wikipedia.org]
Serotonin [wikipedia.org]
Oxytocin [wikipedia.org]
Histamines [wikipedia.org]
Insulin [wikipedia.org]
And this is some text for the lameness filter.
And this is some text for the lameness filter.
And this is some text for the lameness filter.
And this is some text for the lameness filter.
Re:what do they do? (Score:3, Interesting)
(Side note: Histamine and insulin are not neurotransmitters.)
Acetylcholine: What makes your enemies' muscles convulse so strongly they break their own bones to shreds when you hit 'em with acetylcholinesterase inhibitors. (Or when you nail those goddamn roaches with the bug spray, which is pretty much same thing.)
Adrenaline: What you secrete when you're trying to figure out what to do about the simultaneous appearance of a cloud of dense fog coming towards y
Seratonin? (Score:3, Funny)
Re:what do they do? (Score:3, Informative)
Why bother? Someone has already done it. [wikipedia.org]
Re:what do they do? (Score:5, Informative)
For this list:
Acetylcholine: The primary neurotransmitter of the parasympathetic nervous system- in other words, it transmits signals other than fight-or-flight type, and is necessary for normal cognitive function.
Adrenaline: Synthesized from the amino acid tyrosine, and released from the adrenal medulla, this NT takes care of sympathetic responses, the fight-or-flight stuff that jacks up your heart rate and mobilizes the body for action. Also known as epinephrine.
Dopamine: A few steps up in the synthesis ladder for adrenaline is this NT, which is involved in the brain's "reward system" and also in motor control- dopaminergic neurons are damaged in Parkinson's disease, leading to its characteristics.
Endorphin: Actually a group of compounds, endorphins are, as their name suggests, endogenous opioids, and are released in respone to pain. Responsible for "runner's high."
Serotonin: Also known as 5-HT, this neurotransmitter can have a powerful effect on mood and behavior. Antidepressants known as MAOIs inhibit the action of the enzyme monoamine oxidase which breaks serotonin down.
Oxytocin: A peptide hormone released by the pitutary gland, oxytocin is sometimes known as "the love hormone," because it is released during many mating/parental bonding type events.
Histamine: A substance made from the amino acid histidine, it helps regulate stomach acid secretion (it's one of the H's in H2 blocker drugs), but it better known for the powerful inflammatory response it causes in allergic reactions.
Insulin: Peptide hormone released by the pancreas in response to increased blodd glucose levels; has a variety of effects dealing with metabolism and energy use.
I know I'm not supposed to complain about poll options, but the poll leaves out some of my favorite NTs, like ATP, GABA, norepinephrine, and nitric oxide.
Re:what do they do? (Score:2)
Re:what do they do? (Score:2)
When I was hit by a car 2 years ago I didn't feel any pain for several minutes, despite having one hand dislocated off the end of my arm (which was also broken).
Re:what do they do? (Score:4, Informative)
And of course, our favorite exogenous opiates of heroin, morphine, and opium have the same effect because they act on the same receptors!
Also, Prozac, Paxil, and Zoloft are reuptake inhibitors for serotonin, meaning that they cause the seratonin to be reabsorbed more slowly and make more of it available for neurotransmission. These antidepressants are thus known as serotonin-specific reuptake inhibitors, or SSRIs.
Re:what do they do? (Score:3, Interesting)
Don't forget glutamate, the major excitatory neurotransmitter in the CNS. My personal favorite NT is anandamide, which binds to the cannabinoid receptor and is one of the first known retrograde neurotransmitters.
Re:what do they do? (Score:3, Interesting)
Endorphins... (Score:2)
What about.... (Score:5, Funny)
Re:What about.... (Score:5, Funny)
Re:What about.... (Score:5, Funny)
A crummy commercial??? Damn you slashdot!
Obligitory Bania (Score:5, Funny)
missing option.... (Score:2)
Re:missing option.... ANANDAMIDE (Score:2, Informative)
insulin... (Score:2)
http://faculty.washington.edu/chudler/chnt1.html
here's what they do.... (Score:5, Informative)
Adrenaline - fight or flight hormone, gets the body revved up to go.
Dopamine - multi system regulation (heart, kidneys, brain, etc)
Endorphin - opiod like chemical produced in brain...makes you feel good.
Serotonin - modulates mood, sleep and emotion. Target for antidepressant meds.
Oxytocin - causes milk "drop down" in breast feeding and mediates the labor process
Histamine - causes the itching from an allergic reaction
Insulin - controls uptake of sugar from the blood. No insulin = diabetes.
Re:here's what they do.... (Score:5, Funny)
None of you know what to vote for, but the nice guy in the parent comment helped out by explaining the options. To save you even more time reading:
VOTE OXYTOCIN! IT INVOLVES BOOBIES!
Re:here's what they do.... (Score:3, Funny)
So you're saying it puts men to sleep?
Re:here's what they do.... (Score:2)
If I was born with more of it, I wouldn't feel like shit most of the time. In other words, I have depression.
After that I would pick Endorphin. Endorphins are fun
Dopamine (AFAIK) does more than system regulation. Its attributed to mental illnesses like schizophrenia.
Histamine is not a neurotransmitter. Its just a chemical that goes crazy with allergies. When that happens, grab
Re:here's what they do.... (Score:3, Interesting)
Maybe thats why LSD my favorite drug.
I've found it interesting that the molecules of serotonin, psilocybin, mescaline, and LSD (less so), have similar chemical structures as seen here [bris.ac.uk]. What's also weird, is that these drugs are not what I call "feel good" drugs. They are psychedelics that are very tripped out, but I would not consider them antidepressants or anything like
Re:here's what they do.... (Score:3, Interesting)
I've only done MDMA once, and I was also on 4 other drugs (weak LSD, alcohol, some mushrooms, & pot) so I can't isolate the effects totally, but I didn't care for it that much. I sweated profusely and felt speed up and "good". The majority of the high was from MDMA. It didn't seem to last that long. I did the "pure" powder form of MDMA often called "molly". YMMV.
Speaki
Re:here's what they do.... (Score:5, Funny)
Same here. I also want pain-and-suffering damages related to the mental image I now have of Rush Limbaugh breastfeeding a newborn baby.
Endorphins and Sex, BABY! (Score:2)
I realize that slashdot readers might not be in this situation, but I'm sure your right (or left) hand may be sufficient for you to maximize your endorphin, uhhh, loading.
Great cure for headaches, too...
Serotonin, anyone? (Score:5, Funny)
Endorphin (Score:4, Insightful)
Re:Endorphin (Score:2)
I guess I'll have to fall back on the chocolate option...
What about (Score:3, Funny)
Endorphin Rush (Score:2)
Insulin (Score:5, Insightful)
Dopamine (Score:2, Funny)
Re:Insulin (Score:3, Insightful)
I vote for telepathy... (Score:2)
endorphin is not a single neurotransmitter. (Score:5, Informative)
Mmmm... morphine.
Re:endorphin is not a single neurotransmitter. (Score:2)
Oxytocin (Score:2)
Whichever one stops this pain... (Score:2, Informative)
My swim coach taught me that... (Score:2)
Re:My swim coach taught me that... (Score:2)
That's because bananas are a good source of Potassium; lack of potassium and other electrolytes is the main cause of muscle cramps, not anything to do with neurotransmitters. Gatorade, vitamin pills do the same thing.
Re:My swim coach taught me that... (Score:2)
There was nothing worse that being half way down your lane and getting a cramp so bad you leg would bend all the way back and someone had to help you back the wall.
Re:My swim coach taught me that... (Score:3, Funny)
I can't stop voting for Endorphin (Score:5, Funny)
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Feels good though.
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Hmm, Adrenaline?
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Yes, that helped.
Serotonin (Score:2)
Not nice.
Re:Serotonin (Score:2)
Re:Serotonin (Score:3, Informative)
Re:Serotonin (Score:2)
Perhaps that's what I was thinking of. HBO used to run a series called "Autopsy." Not too cheery, I'll admit, but I one point they were analyzing the seratonin levels in the brains of people that had killed themselves. Apparently the levels were through the roof.
My least favorite one is Insulin.... (Score:2)
I'm no biologist, but lately I've done a lot of reading up on weight loss techniques, and even tried (successfully) some of them. It turns out that in addition to lowering blood glucose levels, Insulin also triggers storage of dietary fat as body fat. This second property of Insulin (the first one is lowering blood sugar) is very often ignored/overlooked.
It's somethi
what about... (Score:2)
'nuf said. All this talking made me thirsty
Can't decide! (Score:5, Funny)
Missing options... (Score:2)
GABA (gamma-aminobutyric acid): An inhibitory neurotransmitter that regulates Cl- and K+ cellular ion channels. In the brain, GABA works in the hippocampus and affects memory. The anxiolytic benzodiazepines (minor tranquilizers used in treating anxiety disorders) - including such drugs as diazepam (Valium), lorazepam (Ativan), clonazepam (Klonopin), flunitrazepam (Ro
You insensitive clod! (Score:2)
Save the dolphins! (Score:3, Funny)
Acetylcholine and Organophosphates (Score:3, Interesting)
Anti-Histamine! (Score:2)
Re:Anti-Histamine! Defending histamines a bit (Score:2)
Caffeine? (Score:2, Funny)
As shamelessly stolen from a nameless Farker: "Coffee is good. If you don't make more coffee we'll kill this dog."
Neurotransmitters (Score:5, Informative)
Adrenaline - AKA epinephrine, primary involved in stress response and autonomic regulation of blood vessel tone and heart rate, also produced in adrenal glands for stress hormonal response, and your doctor's favorite drug of use emergency treatment of low blood pressure and ventricular fibrillation.
Dopamine - another catecholamine type neurotransmitter, involved in autonomic blood pressure regulation, low dose increase blood flow to kidney, wheras high dose will increase vascular tone and heart contractility.
Endorphine - a polypeptide neurotransmitter, involved in pain transmission and actually blocks transmission of pain signals to the brain. Also results in mild vasodilatation.
Serotonin - AKA 5-hydroxy-tryptamine, mostly found in central nervous transmission in brain, and involved in mood regulation; the theory goes low levels of serontonin activity results in depression. High levels can also lead to hallucinations as in LSD - a serotonin analogs. Most modern antidepressant drug, e.g. Prozac, Celexa, Sertraline, slow down the uptake of serotonin neurotransmitter from synaptic cleft to effectively raise serotonin levels.
Oxytocin - another polypeptic neurotransmitter, involved in neurotransmission of lactation - production of milk in mammary glands.
Histamine - not a catecholamine nor a polypeptide molecule. Involved in allergic response as in hayfever and asthma. Also involved in the gut nervous system in stimulating the production of hydrochloric acid in stomach causing heartburn, ulcers and aiding digestion of proteins.
Insulin - not really a neurotransmitter, mostly a hormone, produced in the beta islet cells of the pancreas and involved in the regulation of glucose uptake, production and storage. Lack of insulin production leads to Type I Diabetes mellitus, whereas Insulin resistance as in obesity leads to Type II Diabetes Mellitus. May also insulin receptors in brain regulating hunger. Counter-regulatory hormones include glucagon and growth hormone.
Re:Neurotransmitters (Score:3, Informative)
Not sure if parent's quote is accurate or not (IANAD), however I do know that LSD (and related psychadelics) do not cause hallucinations by raising the Serotonin level - what they do is mimic the chemcial structure of Serotonin, so receptors where it normally bonds to it cannot since LSD/Psilocybin/etc are taking it's place.
Now Serotonin is a deactivating neutrotransmitter, meaning it slows/stops the progression of chemical sign
Serotonin (Score:2)
It also REALLY helps reduce the impact of serotonin depletion on your mood if you take ecstasy, take a couple of 5-HTP on your comedown and the "downer" is almost complet
Instead of Oxytocin... (Score:2)
Interesting. (Score:2)
No contest! (Score:3, Informative)
"Although the effect of psychotropic drugs on various hormones is not certain, their effect on several neurotransmitters influencing sexual function is well established. Dopamine is the neurotransmitter in the mesolimbic "pleasure center." Increasing dopaminergic activity may enhance sexual response, and blocking it may compromise response."
I'd call that a winner, folks.
Re:No contest! (Score:2)
Dopamine. Yea, definitely dopamine [biopsychiatry.com].
With seratonin [biopsychiatry.com] as a close second.
Please respond, Business Plan in the works (Score:2)
Oxy (Score:3, Funny)
Missing Option (Score:2)
There's a popular one missing (Score:5, Funny)
Re:There's a popular one missing (Score:3, Insightful)
Glutamate and GABA? (Score:3, Informative)
And, why yes. I am a neuroscientist.
DMT (Score:2)
A missing tryptamine (Score:5, Interesting)
Re:A missing tryptamine (Score:5, Informative)
Poll options badly mangled (from the poll author) (Score:3, Interesting)
I had instead NO (nitrous oxide) - the controversial one - and the CowboyNeal option "My nervous system is purely electrical". Why they had messed up with my poll is beyond me.
Re:Neurotoxin (Score:2)
Agent Orange
McDonalds
Television
Perchlorate
Let's leave this planet, and go somewhere else more fun with less restrictions and fear. Who's with me?
Re:Neurotoxin (Score:2)
ethanol.
Re:Beer? (Score:2)
ObClavin (Score:5, Funny)
But in the immortal words of Cliff Clavin:
Re:ObClavin (Score:5, Funny)
Re:Beer? (Score:2)
What's your favorite neurotoxin?
Re:Dopamine (Score:2)