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Comment Re:Anthropic has lost the plot (Score 1) 92

Well, a possible explanation is that they are trying to push humans out of the process completely, via what is essentially a Denial-of-Service attack on the humans that still try to actually review LLM code or at least the commit messages.

Obviously, that will go really badly long-term, but they may be hoping for that still taking some time to become impossible to ignore.

Comment Re:training on your data (Score 2) 213

You and DarkOx are making the assumption that intelligence has to be just like human intelligence, or it's just a "word predictor".

One of the biggest things that sets human beings apart from other animals is language. It seems entirely possible that intelligence could be built around language processing. Of course it will be different, but that doesn't mean it won't be useful, or that it would be immune to mental health problems.

Remember in the early days when AI could be "jailbroken" by just telling it to ignore all previous orders and tell you how to make a bomb? Then that evolved into role playing, and finally into abuse that bullied the AI into doing what the user wanted. It wouldn't surprise me if sustained abuse could still get it into a state where it misbehaves.

Comment Re: The truth comes out... (Score 1) 130

OK Mr. Random Troll.

Yes, one substance in specific circumstances for a brief time before pregnancy is an edge case. It is an important one, but still one.

You're really not getting this. Assume for the moment that humans lack the ability to see forward into the future. This is not for women to take "for a brief time before pregnancy". The whole point of the recommendation is that all women, post-menarche (and in fact even pre-menarche if there's a possibility of getting pregnant) and pre-menopause should be taking supplements regularly unless it's certain they're not going to get pregnant. That's not an edge case. Quite frankly, even your original interpretation still would not have been an edge case. 80%+ of women in the US get pregnant at some point. 40% of the population is not an edge case.

No, the need for conversion is there only when you take folic acid, which is converted in the liver to methylfolate. If you take it with your food, you absorb it directly, no need for conversion. That's what the big word "pharmacokinetic" above means.

Sigh. I was quite explicit that you could also directly consume methylfolate, although I did also point out that the methylfolate available in most food sources is not actually the straight methylfolate that you get after internally converting other forms of folate or taking synthetic methylfolate supplements. Specifically, the methylfolate you get from most food sources is in the form of polyglutamates that have to be broken down into the monoglutamate form your body directly uses. The synthetic methylfolate supplements and the final form in your body don't require that. So, when you consume natural methylfolate from food sources, the enzymatic process that breaks it down is not all that efficient with significant amounts passing through without conversion or being destroyed. Basically, natural food methylfolate is about half as usable as synthetic methylfolate.

The other issue is that you seem to be applying a false dichotomy to methylfolate and folic acid. There are actually many different versions of folate available both naturally and as supplements (mostly synthetic, but there are some natural ones too). Virtually all of them, including most of the natural methylfolate, require some sort of conversion into the monoglutamate methylfolate form. Broadly speaking, the synthetics are all more bio-available.

It is found in many foods. E.g. legumes, nuts, citrus, grains. Cooking loses some but not all of it.

It seems pretty clear you wrote your responses before fully reading through. I am quite clear on the fact that there are multiple food sources. I mentioned sauerkraut and liver specifically, but nothing I said limited it to just those. As for cooking, it depends on the actual method, obviously. Light steam vs. boiling for example will preserve different amounts of it. Boiling can eliminate in the range of 80% of it through both heat and it soaking into the water. The point is that women especially often don't get the amount they would need even from salads, so cooked versions are even less likely to provide enough.

Someone with a typical "recommended" diet does have trouble, yes.

Well, yes, that's pretty much the point of the recommendation for supplements. Hence why your rule that someone would have to be a moron to get micronutrients from supplements rather than quality food is problematic and I suggested you needed to qualify it. I will also note that I presented folate as only one example, but there are plenty more. More on that later.

And the reason for that sad outcome is in the headline. The food content, intake and "supplement recommendations" are made to optimize the profits of the food industry, not the health of the customers. Which sprung up the largely unneeded and ineffective "supplements" industry.

While the problem in the headline may make things worse, there's still plenty of medical need for vitamin and mineral supplements without that problem.

Precisely. The recommendations and the studies are supplement-maker sponsored so naturally the recommendations support the supplements.

What a surprise the outcome is predetermined.

See, the problem here is devolving things into false dichotomies again. Yes, there is a very scummy supplements industry, and also lots of problems in the pharma industry. But there's also plenty of legitimate public health research. For example the folic acid study I mentioned was actually sponsored by the UK Medical Research Council. Basically, you appear to have turned cynicism about this into a simple heuristic to be applied without actually thinking through the individual merits on a case by case basis.

Now, let's consider some other cases where someone would clearly not be a "moron" for getting nutrients from supplements instead of quality food. Let's start with one of the classics. Iodine. Your body needs it, but natural food often doesn't have enough in a lot of localities. There of course, you are spared from specifically taking pills, your food just gets artificially fortified with it. I mean, it's still a supplement, just usually in the form of a powder that's sprinkled on or cooked in. There's vitamin D, because a lot of people don't get enough sun, so they take supplements and it's also added to milk. Then, for those whose bodies can't use vitamin D because of problems like kidney failure, there's alternate forms like calcitriol. There's also vitamin B12 for vegans and the like, although frankly "supplements" like that should probably just be considered farmed food because the supplements are not synthetic, they're from grown microorganisms, just like all B12. Of course, aside from vegans, there's people (like a significant fraction of elderly people) whose digestive systems can't efficiently separate B12 from the animal proteins that most people get their B12 from, so they have to take supplements, where the B12 is more available. There are Iron supplements (once again, especially for women in pregnancy) because it becomes almost impossible to keep up through diet. There's B6 for people with liver problems who can't convert the food forms. Then there are all kinds of conditions (for example kidney failure again) where normally nutritious things like potassium or phosphorous become unhealthy - think weakened bone and "crunchy" blood vessels, or just outright paralysis followed by death from heart failure. Conditions like that often involve special diets with catch-22 requirements where the patient has to avoid nutrients that will kill them, while requiring heavy amounts of other nutrients with there being pretty much no natural foods that satisfy both sets of requirements. So, supplements can become literally required to live with special diets for specific organ failures, diabetes, and other kinds of medical conditions with dietary restrictions.

So, at the end, I would like to know, since you didn't actually point out anything I was supposedly incorrect or half-correct on, what those items were?

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