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Comment Re:Paper-oriented troglodytes (Score 1) 97

> that in voting precincts are local, so there are likely to be people there who know the person voting

Most such fraud would be done in bigger precincts, not small towns, so as to blend in better.

> so if it goes bad, you're right there to be caught.

Somebody who ready to run can outpace Barney Fife.

> you have to research the particular details of a specific person.

I'm sure Putin and Xi have a copy of everyone's drivers license.

Comment Re:Brakes off on a downhill society. (Score 1) 97

Gotz more! Names Jimmy Kimmel called Don: Trumple Stilskin Trumple Orangeskin Troompa Loompa Donny Boo Boo Cheeto Chief Unhappy Gilmore Commander in Beef Mar-a-Lardo Donny Bone Spurs Colludicris El Crappy-tan Hairy Poppins King Tutan-con-man Abra-scam-lincoln Douche-olini Typhoid Donnie [got staff sick] Flabbio Tangerine Twitter Machine Tandalorian Darth Tax Evader Jabber the Hutt Orange Julius Caesar Spready Krueger [Covid] Dingus Khan Putin's Pee Pee Pal Lie-ger Woods Tweety Gonzales Tanny Soprano Q-A-Don Dictator Tot Quid Pro Combover Prisoner-Elect Star Spangled Tanner Gaseous Clay Smellvis Yellvis Fibberace Reich Tyson MAGA Teresa Pork Choppo Commander & Thief Tannie Oakley Magaroni & Cheese Scamburglar Gassolini Groper Cleaveland Mar-a-Cloggo Vladimir Gluten Carrot Bottom Tannibal Lecter The Tanchurian Candidate Kim Don Un Donye West Genghis Don Burger Jean King Julius Squeezer Uncle Scam Merrill Flinch Keester Bunny King Hungry the Eigth Petty Rosevelt Gangus Conman Lie-a-tollah Founding Frauder

---From others:---
Moutholini Mango Mussolini Don Laden Don Qaeda Hitliar Agolf Shittler Agolf Tottler Fattler ADHDolf The Count of Mostly Crisco (from Colbert) Cheeto Corleone Don Snoreleone Dozo the Clown The Nod Father Flush Gordon Hannibal Leakter Tribble Top Mess-iah Sharticus Farticus Coupy McTintFace King Tint-Uncommon Darth Vapor Donvict Nobel Price Ferrel Pharaoh Mango Unchained Tinted Toddler Yosemite Yam Flaky McCakey Bruisey McSnoozy The Great Fatzby Blob the Builder Teddy Dozevelt Dr. Strangelump Clowntator

(sorry about the formatting, Slashdot didn't like the original)

Submission + - This frog bacterium wiped out cancer tumors in mice with a single dose (sciencedaily.com)

fahrbot-bot writes: Science Daily has reported that scientists at the Japan Advanced Institute of Science and Technology (JAIST) have identified a naturally occurring bacterium from the intestines of Japanese tree frogs (Dryophytes japonicus) that demonstrated remarkable anticancer activity in mice. The findings, published in Gut Microbes, introduce a new approach to cancer treatment that uses living bacteria to directly target tumors rather than simply altering the gut microbiome.

In a mouse model of colorectal cancer, a single intravenous dose of E. americana completely eliminated tumors, producing a 100% complete response (CR) rate. The researchers emphasize that these findings are limited to mice, but they believe the results provide an encouraging proof of concept for developing new bacterial cancer therapies.

First, E. americana directly attacks tumors. As a facultative anaerobic bacterium, it thrives in both oxygen rich and oxygen poor environments, allowing it to multiply inside the oxygen deprived regions commonly found within tumors. Once there, the bacterial population increased by roughly 3,000 fold within 24 hours after treatment, directly damaging cancer cells.

Second, the bacterium stimulates the immune system. Its presence attracted T cells, B cells, and neutrophils into tumors. These immune cells then released inflammatory signaling molecules, including TNF- and IFN-, which strengthened the immune response and promoted cancer cell death.

One of the most striking findings was that E. americana accumulated almost exclusively inside tumors and did not colonize healthy organs.

They found that the bacteria were rapidly cleared from the bloodstream, with a half life of approximately 1.2 hours, and became undetectable within 24 hours. No bacterial colonization was detected in healthy organs, including the liver, spleen, lungs, kidneys, or heart.

The treatment caused only mild, temporary inflammation that returned to normal within 72 hours. During a 60 day observation period, the researchers found no evidence of chronic toxicity.

Comment Re:Non-lethal weapons must be tested on the promot (Score 1) 141

How is that a lie? I have literally spoken to multiple people who insisted that they had been through being sprayed with pepper spray, or other less lethal weapons who eventually admitted that they got the inert versions or special safety circumstances like wearing padding, etc. In this discussion, someone mentioned training where they were exposed to tear gas, if I recall correctly. They themselves pointed out that it was a weakened version for training. In that case, they weren't using their experience to belittle people who have been through the actual experience, but I've encountered plenty who do. One of my favorites for that kind of attitude is people claiming that torture isn't a problem because special forces guys go through things like waterboarding in training. My usual argument about that is that it's like saying that rape isn't bad because some people have consensual sex. But another important point there is that the experience is a controlled one conducted by friendlies and with a predefined start and end point rather than days, months, weeks, years, or even decades of unpredictable assaults conducted by torturers who don't really care if the victim dies. There's obviously a very big difference in the watered down training experience both in substance and in stakes, but some people still want to play pretend that they're somehow equivalent.

Comment Re: Harm (Score 1) 103

There are, indeed, situations where plastics have served important functions and saved lives. At this point I can't even count the number of plastic things that have been shoved into and implanted in my body that have saved my life or helped me medically, and I recognize that there's no good substitute for them. At one point I was going through more than a quarter of a ton of medical supplies a month, and basically all of it came surrounded in plastic in one way or another (to be clear, it's not a quarter ton of plastic waste, the supplies weighed a lot more than the plastic, but it was still a massive amount of plastic. That doesn't mean that plastic should be improperly disposed of so it ends up in the environment as solids. Or, for that matter, that the mostly CO2 it was converted to afterwards isn't an environmental issue. In general, plastic should always be properly disposed of, not to mention that its use should be minimized. Whatever might be vitally needed, there's a massive amount of plastic out there that's used completely unnecessarily. Many things made of plastic that don't need to be, massive amounts used in packaging that's completely useless, etc.

As for the rest of the shit we litter all over the world, we shouldn't be doing any of that, so your question is a bit silly. Still, it's a question of categories. Biodegradable waste, where it doesn't overwhelm the local environments ability to safely handle it is generally less of a problem than plastic. Some metals also aren't that much of a problem because they corrode and eventually just join back up with the ground again. However there are plenty of things like copper, arsenic, lead, mercury, etc. that can be much worse than plastics. For absolutely all of these, it's better to have a plan rather than overproducing and/or randomly dumping.

Comment Re: Harm (Score 1) 103

It's widely detrimental changes to the environment, and houses can, in fact, count. Generally anyone with a realistic understanding knows that calling some things pollution over others is a matter of degree. For example, all coolants being released into the air are technically pollution, but some are hundreds or thousands of times worse than others. In the end, it comes down to effects and equilibrium/homeostasis. For example, are you releasing something into the environment at a rate where the effects build up, or do they just stay at current levels? If levels are rising, where will they reach homeostasis if at all. Are the levels at homeostasis acceptable, or do they produce unacceptable problems? Are there potentially unknown issues? Issues where A at a certain level and B at a certain level are fine alone, but both together at that level is a problem?

All of these things and more need to be considered. These are complex questions and how things are categorized can vary and be situation dependent. The simple rule though, is, if you must err, err on the side of caution.

Comment Re:Harm (Score 1) 103

I mean, do you read what you write to yourself? "...questioning the safety of vaccines...". As if vaccines are some monolithic entity. Hey, if you want to do a meta-analysis or scientific review of all published papers on vaccine safety, be our guest. That could be interesting. Likewise, if you want to consider a single, specific vaccine, and seriously discuss the safety details and the public health ramifications or even just the philosophy of public health, also be our guest.

If however, you think you're making a contribution by "questioning" the very concept of whether or not vaccines can be safe without actually presenting research or even theories or anything like that... Well it seems like you're just being a pseudo-intellectual who isn't even operating at a grade school level, but somehow thinks that you actually have some superior towering intellect that the rest of us lack. This may be reading way too much into what you said, but most people who say things like what you said are ignorant of the vast scientific apparatus and actual expert discussion that actually exists on the topic. Very often that ignorance is intentional. Also, very often, the person saying such things simultaneously thinks that they're some sort of amazing original thinker, while explicitly using the verbal shortcuts and dog whistles of the groupthink echo chambers they belong to and get frustrated when people in outgroups don't instantly align with the same groupthink when the magic words are spoken.

If you have something to actually say about either vaccines or the actual topic, go ahead. There have, in the past been plenty of discussions on things like vaccines that actually discuss real concerns. If you have that, go ahead and if there's any substance, it can be discussed.

Comment Re:More Harm (Score 1) 103

Both you and the GP are following a fairly Eurocentric perspective though. I mean, you even note sugar as a luxury, but the reason it was a luxury in Europe was because sugar cane did not grow well there and, as you note, sugar beets weren't a thing yet, so the sugar they did have was part of the spice trade from areas where sugar cane and the other spice plants grew. There was heavy sugar production a thousand years ago in the middle east (where they basically invented the modern idea of dessert). China had heavy sugar production around the same time. India was producing sugar at high levels over two thousand years ago. Observations of the health risks of excessive sugar consumption such as diabetes goes back over two thousand years.

Production in the Caribbean lead to high availability in Europe through an increase of what we would today call vertical integration. Instead of having to deal with trade through the Middle East and numerous middle men, Europeans owned the plantations, the people working on them, the refineries, and the transportation networks. So, through mercantalism, slavery, and just general exploitation all around, cheap granular sugar came to Europe, but it was not the first time in history that it was widely available to populations.

Adding sweeteners to foods does go back thousands of years even in Europe though. The ancient Romans, for example, often used a calorie-free, non-nutritive artificial sweetener. Of course, it was lead acetate, so it had some health problems of its own.

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