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Comment Re:Cancer vs common cold (Score 3, Informative) 52

E47-inducible cell lines were generated by infection with
a retroviral vector expressing E47 fused to a tamoxifen-inducible
modified estrogen receptor (MER).

The way this was done was really clever: it uses a virus that causes cancer to treat cancer. Specifically, the retroviral vector is an engineered strain of Moloney Murine Leukemia Virus (MoMuLV), which can cause leukemia in mice (it is not known to cause disease in humans, though retroviral infection does carry at least a small risk of mutagenesis). The viral vector inserts a gene that expresses the protein E47, which acts in a variety of ways to make cancer cells revert to acting like healthy cells.

This is an exciting idea, though as the press release notes, "we are screening for molecules—potential drugs—that can induce overexpression of E47." That's a way of noting that retroviral vector gene therapy is in its infancy, and that it would be much better if we could find a small molecule instead.

These findings prompted us to ask whether
the growth arrest and acinar gene expression induced in vitro
might be sufficient to diminish the tumor-forming potential of
these aggressively growing cells. Indeed, temporary induction of
E47 for 2 to 8 days in vitro produced stable cell cycle arrest and
trypsinogen expression in transplanted human PDA cells. It will
now be of interest to investigate the effects of E47 on the growth
dynamics of established tumors.

And also the above- established tumors notoriously mutate and become genetically heterogeneous over time, greatly increasing the chances that at least some of the cancer cells are resistant to whatever line of attack you throw at them. Cancer cells that have mutant forms of E47's targets wouldn't be reprogrammed. Still, any advance against pancreatic cancer is highly welcome.

Comment Re:So is it REALLY good? (Score 1) 181

So you're telling me gcc inlines functions from libqt when you compile a program against qt's headers?

But regardless, C++ has a class encapulation system which allows early binding, which ObjectiveC does not

Binding is still done at run-time, and is still a matter of setting a pointer somewhere. It's functionally similar to a page fault: if it happens and it's satisfied, the computer just calls as normal; if it happens and isn't satisfied, the computer does some work first. All you're changing is the point in time the work is done, not the number of times.

Comment Re:Instead... (Score 1) 356

I'd be the first to agree that Google shouldn't get to dictate how the Web works and that sometimes Google or at least some its

They shouldn't get to dictate how the web works but then you basically say don't like it don't use Google... I'm confused... are sites able to chose not to use Google? What sites gets most of their traffic from a different search engine?

However, if you're relying on Google's service for most/all of your visitors to find your site at all, you have to play by their rules if you want the best treatment from them. This is the basic principle of SEO, and it's as old as search engines themselves.

What happens when those rules begin to stray from principals fewer people agree with? Google is more or less a monopoly.

Comment Re:You no longer own a car (Score 1) 649

I have never gone to a dealer for brakes. I did go to the Mazda dealer for a brand new windshield, new engine mount (broken), oil change, tire rotation, and a diagnostic of why my check engine light was on (faulty part), at a total cost of $328. The exhaust had broken off the manifold, and they repaired that as well.

I've been quoted $676 for two wheels at a Goodyear-Gemini mechanic; $550 at a Mr. Tire; and over $800 at an independent mechanic down the street.

Comment Google imposing itself on the world (Score 1) 356

You can always count on the Internet to implement good concepts poorly and parade the result as cutting edge technological innovation.

One thing I've always liked about HTML was from very early days before even CSS or Google the "promise" of targeting vast arrays of client form factors with the same information. This sounded great but proved in to be mostly unnecessary and divorced from reality.

Rise of "Responsive" sites more often than not translate back into frustrated desktop, laptop and tablet users with sites resembling pre-tables era childish web layouts boasting comically large fonts and painfully low information density. Paradoxically these "features" persist even when viewed from my mobile phone with the same display resolution as a large HD TV or desktop monitor. Very few appear to actually be capable of designing single scalable sites that don't suck.

There was a time when mobile sites were necessary. Given the proliferation of display sizes, LTE, multi-core multi-ghz processors with GBs of RAM.. that time has came and gone. Google is trying to catch up to a need that for the most part was already solved by hardware and software innovation and no longer exists.

If your going to punish sites for not as judged by a naive non-human algorithm offering something that is not "appealing" to a human using a client of a specific form factor or capability then do so across the board without bias. When I do a Google search from my desktop penalize all search results that consist of mobile handset optimized sites with comically large fonts and childish layouts.

What determines the worth of a website to me has never been layout it has been content and lack of annoying BS. All "looks over brains" does is give legions of spam trap link-baiting sites an even greater advantage.

Stupid all around to say nothing of negative implications of people waking up to the dangers of Aggregation of power into the hands of so few.

Comment Because they are smarter (Score 1) 336

How about by genetics?
The DNA between a male ape and a male human is so small it's almost the same amount as the difference between the genders! A great deal of fighting was done just to admit women as equals and that hasn't been won worldwide and nobody seems to treat them as equals yet...

Point is, genetically they are really close to an accepted group (majority actually) which wasn't recognized in the past.

Dolphins only have our brain size; their brains are full of fat. literally. the ocean temperature's impact on submerged body temperature is extremely great compared to the wind. They need fat heads for temperature stability since analog brains function around the influence of environmental factors like temperature impacting all those massively parallel chemical reactions. Your body does a great deal to maintain brain temperature so it can function not because neurons are so much weaker.

Comment China was just the lowest humans would go (Score 1) 289

Sure humans can be exploited bit more than the Chinese, but not a great deal more and not for much more output. Don't forget that very few nations would be willing or capable enough to support what China has done.

The machines are now beginning to replace the lowest human working conditions for mass production.

Labor of Slaves, then unprotected workers, then exploited external workers:
It has always been about how much we can get away with. Now we have reached the point where soon the most desperate humans will be unable to compete against machines. It is the story of John Henry but more broad than ever before.

It need not be 100% machine-- where gamers could be unwittingly helping their parents lose their jobs by providing the tiny bit of intelligence the machine lacks their parents used to provide. Small farmers have been dying off for many reasons and no computers were required; they are an example of empowering 1 person to do the work of dozens. Robots will take that far beyond what machines alone could do... to the point where the human in the equation is only an owner and everything is artificial.

In our lifetimes there will see the 1st 100% artificially run corporation; some private owners will decide to be the 1st, it is not like most CEOs are actually that useful or don't already decide everything based upon stats (which a machine could do with a little input by survey, game, or the owner.)

Comment Re:We can learn from this (Score 1) 163

The US political funding rules allow any organisation to buy 'issue' adverts that aren't specifically pushing a single candidate, with no limits. Why not use this in the next election to run prime-time ads listing exactly which corporate interests each candidate has taken bribes from and their amounts, and the legislation that it bought. If taking money from certain organisations starts costing more votes than it buys, then politicians will be a bit less eager to take it...

Comment Wikipedia is the BBC and the European union. (Score 1) 356

Some members of the Pokemon Mafia--Team Rocket, Jessie and James--have been searching for Pikachu.

Sites that have no mobile versions--which includes sites owned by Wikipedia, the BBC and the European Union--will find themselves with lower Google search placement, starting today.

See, Wikipedia is the BBC and the European Union.

To make this a serial list instead of a parenthetical expansion, you need a comma before the conjunction on the last member of the list. Consider the following list: Ham, turkey, bacon and eggs, peanut butter and jelly, fish and chips. Now consider the following list: Bacon and eggs, peanut butter and jelly, fish and chips, ham and turkey. This is a different list, as it lists an item called "Ham and turkey".

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