Comment Re:Hmm (Score 5, Interesting) 39
Wonder if "untangling" proteins could help with Alzheimers and "Mad Cow?.
There are two main theories about Alzheimers. The dominant theory is that it's caused by beta-amyloid protein which forms plaques. The minority theory is that it's caused by tau protein which forms long filaments called "tangles"; these tangles gum up the neuron and eventually cause it to burst. http://taurx.com/tau-tangles-i...
My father during his PhD discovered that a common dye, methylene blue, causes those filaments to untangle. He formed a small pharmaceutical company to pursue this idea. They tweaked the chemical a bit, including with heavy duty computer number-crunching to simulate its 3d structure and mode of interaction. They had great results in Phase 2 trials, and their Phase 3 trials are currently underway. Fingers crossed.
That said, Alzheimers disease is a graveyard of pharmaceutical funding. $18+ billion dollars put into drug trials so far (not just "foundational research"), primarily on the beta-amyloid hypothesis, but with nothing yet to show.