Thought I would also mention how bizarre the schistosoma (genus) parasites actually are (more details can be found e.g. on wikipedia).
The eggs are deposited into water by infected humans, and infect certain snails. The snails later release a larval stage which has a tail, but no functional digestive system. These penetrate the skin of a human host, losing their tails in the process. The next larval stage is a few micrometers in size and has a sucker; it can now eat. They typically migrate to the lungs, where they will mature for about 1 week, living off the blood of the host.
As they mature into adult parasites, which are up to ~10 mM in size and visible to the naked eye, they migrate again, often to the liver or intestine. If possible, they will also find mates. The female parasite lives in a canal formed of by the male flatworm's body rolling up. The breeding pairs are monogamous and individual parasites may live for decades. During this time, the pair will reproduce continually, producing up to thousands of eggs per week (depending on species).
The eggs are deposited into the infected person's feces, where they find their way back into the water supply, but about half of the eggs become trapped in the body. These eggs mature normally, releasing many antigens which contribute to an active immune response which leads to most of the symptoms of the diseases.
The parasites are highly evolved to fit their human hosts, to the extent that they depend on human enzymes in order to complete certain essential metabolic pathways. They also have genes which are highly similar to human genes, which may help the parasite evade the immune system (such genes could have evolved or been acquired through horizontal gene transfer).
If it sounds unlikely, consider that a single bacterium, which only doubles every generation, can rapidly give rise to large colonies. For example, with a reasonable doubling time of 1 hour, 1 bacterium will become ~268 million in 48 hours. In contrast, viruses can create hundreds or thousands of copies with each generation. When actively replicating, they can spread very quickly.
The variety in diversity of viral populations in recent infections is probably caused by a variation in initial viral dose (b/c more particles make genetic diversity more likely), and also by effects like the two you mentioned. I'm a graduate student in biochemistry, and I've learned never to assume that those types of phenomena are mutually exclusive.
By the way, this popular summary describes a model experiment on the feasibility of very low dose infections and how genetic diversity of the viral population varies probabilistically with the initial dosage.
These authors aren't the only ones to have identified a link between schistosomiasis and HIV, see this 2011 paper in PLoS NTD for example.
It seems pretty obvious that any source of genital sores is going to increase the risk of HIV transmission, especially considering that this is the entire basis of increased infection rates for individuals engaging in anal sex.
Still, the link to HIV should only slightly increase our desire to deal with schistosomiasis, because schisto is already the second-most socio-economically devastating illness in the world (after malaria). It causes liver and kidney damage, diarrhea, and vascular disease. It is associated with bladder and colorectal cancers, increases metastasis of other cancer (including breast cancer), impairs mental and physical development in children, and leads to reduced cognitive function and work ability in adults. Further, only one drug is widely used to treat the disease (praziquantel, aka PZQ), and resistance has begun to be observed. 200 million people are believed to require treatment, and more than 600 million are at risk of infection.
Disclaimer: I develop automated drug screening methods against NTD, including schistosomiasis
When DNA is replicated in most life-forms, there are extensive proofreading mechanisms which identify replication errors, cut them out of the DNA, and then re-copy those sections.
In contrast, HIV does not extensively proofread new DNA during viral replication. That means that copy errors are quite likely, and over time lead to a heterogeneous population of mutant viruses in an infected person.
Like other viruses, HIV has evolved a balance between correct and incorrect DNA replication which keeps the virus deadly while still evading the immune system.
internet, cable TV, etc. are sold this way
No, they aren't.
Comcast doesn't give you a free TV or computer if you promise not to cancel for two years and pay more than folks who already have the device.
And as long as all or most sellers have similar plans and prices, they can get away with it.
This, though, is correct. It is easy for "competitors" to collude against the consumer. For example, if AT&T raises prices in a way which is irrational unless Verizon does the same, Verizon and AT&T can collude to raise prices in their entire industry without any direct communication or signalling.
Can't afford that $700 smart phone? No problem, get it on credit.
convenient monthly payments (which you may still not be able to afford) solves your problem.
This is contradictory. If credit lets me buy the phone outright (and then save more than the cost of the phone on reduced service fees over two years), why would I need a subsidized phone or an installment plan?
Easy credit doesn't explain why people accept grossly higher costs for contract phones. Instead, it raises the question: why don't people use credit to amortize the up-front cost of the phone, and then save money on service fees?
As geeks stuff like this often seems really important
Or as a person with a limited budget? I think a lot of people can basically afford to overpay, and maybe they know they're overpaying, but they think it's not worth their time to figure out a better option.
The rule on staying alive as a forecaster is to give 'em a number or give 'em a date, but never give 'em both at once. -- Jane Bryant Quinn