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Submission + - Megaupload Shut Down by US Federal Prosecutors

An anonymous reader writes: Fox News reports that 'federal prosecutors in Virginia have shut down one of the world's largest file-sharing sites,, and charged its founder and others with violating piracy laws — a day after a 24-hour blackout of popular websites such as Wikipedia drew national attention to the issue.' Is Dropbox next? Youtube? What about the DMCA's safe harbor provisions?

Submission + - DIY Servers for Cloud Datacenters pick up the pace (

SpaceCracker writes: According to this Bloomberg article, hardware giants like HP and Dell loose out to Intel and others who were quicker to adapt to the trend of shifting from traditional off-the-shelf servers to custom-tailored machines.
"Hewlett-Packard, Dell and companies that sell the computers off the shelf are losing sales in a key market because Facebook and larger rival Google Inc. (GOOG) are leading a switch among Internet companies to do-it-yourself servers... Buyers say custom servers provide a cheaper, more efficient way of meeting the boom in demand for personal data shared via the Web... “It’s a completely different animal” than corporate servers, said Rejeanne Skillern, head of marketing at Intel’s cloud computing division."


Submission + - Colchicine targets tumor blood supply (

Giant Electronic Bra writes: The drug, known as a "vascular disrupting agent" (VDA), is based on colchicine — a highly toxic substance in the flowers, leaves and seeds of the autumn crocus. Previous attempts to employ it to fight cancer have failed because of the compound's extreme toxicity, but Prof Patterson's team found a way of rendering the drug harmless until it was exposed to a protein enzyme called MMP1 only found in tumours.

"Our novel delivery method uses the presence of this active MMP to activate the drug, which attacks and breaks down cancer blood vessels, destroying the tumour's lifeline", said Prof Patterson, who will outline the research at the British Science Festival taking place at the University of Bradford this week.

Tumor angiogenesis, the growth of blood vessels in solid cancers, has long been seen as a key process in tumor development and growth. Could this new form of colchicine finally provide a way to disrupt tumor blood supply and provide a magic bullet against many forms of cancer? Human trials may begin in as little as 18 to 24 months.

The Courts

Submission + - 5 years in prison for selling fake Cisco gear (

angry tapir writes: "A Virginia woman was sentenced Friday to five years in prison for leading a "sophisticated" conspiracy to import and sell counterfeit Cisco Systems networking equipment. In addition to the prison time, Judge Gerald Bruce Lee of U.S. District Court for the Eastern District of Virginia also ordered Chun-Yu Zhao, 43, of Chantilly, Virginia, to pay US$2.7 million restitution and a $17,500 fine."

Submission + - Gut-Check Time for Windows 8, Microsoft

theodp writes: GeekWire reports that, for better or worse, the upcoming week is shaping up as one of the most pivotal in Microsoft's history, as the software giant makes its pitch for Windows 8 at two important conferences. First, Microsoft will be huddling with hardware and software developers beginning Tuesday at its sold-out BUILD conference ('BUILD will show you that Windows 8 changes everything'), where it's rumored that Samsung will unveil a Windows 8 tablet. And on Wednesday, CEO Steve Ballmer and other execs will be holding the company's annual Financial Analyst Meeting, which was delayed from its traditional summer date to allow the company to put its Windows 8 strategy in context for Wall Street. So, are we about to finally see the realization of Microsoft's vision for Information at Your Fingertips (Part 2), which Bill Gates introduced with a hokey video at Comdex 1994?

"Help Mr. Wizard!" -- Tennessee Tuxedo