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Comment Re:Again this is not true (Score 1) 98

The real virus does not stay confined to your lungs, nor even mostly confined to your lungs

Of course not - but it is a long way from the blood and the heart.

That's simply not true. COVID caused a 30% increase in heart attack deaths among young adults during the first two years of the pandemic, with undiagnosed myocarditis believed to be the primary culprit. Myocarditis and pericarditis are, respectively, inflammation of the heart muscle and the area around it, caused by an immune response to an infection.

So COVID absolutely can get into your blood, can infect blood cells, and can spread anywhere in your body. It isn't guaranteed to reach your heart, and in fact, serious heart complications are relatively rare, but it can, and COVID-infection-induced myocarditis and pericarditis are both well-documented at this point.

Also, I think you're also misunderstanding how intramuscular injection works. The vaccine isn't put into your bloodstream like an IV. It is put into a muscle. And unlike the virus, which is self-replicating and can move around your body over time, the vaccine infects a cell once and produces output for a specific amount of time before it self-destructs, so unless you get very unlucky and end up with some of the vaccine getting somewhere that it doesn't belong, the overwhelming majority of the vaccine stays confined to the muscle into which it is injected, as do most of the spike proteins. To the extent that it spreads, it mainly ends up in the local lymph nodes. The amount that ends up in random parts of your body is normally very small.

That's why the statistical risk from the virus is considerably higher than the risk from the vaccines. Even though your immune system is attacking those foreign proteins, it almost never is happening in your heart with the vaccine, whereas it is much more likely to be happening in your heart with a natural infection, and that risk increases by something like 11x if you have never been vaccinated because it takes longer for your immune system to realize that it needs to kick into gear and attack the virus.

Why do you think one of the most common first symptoms of COVID (*before* respiratory symptoms) is diarrhea?

Because mucus full of the virus goes down the throat. Epithelial spreading from top to bottom.

If the actual virus was getting to your heart muscles it's already a very serious infection, even if it is relatively asymptomatic.

Yes, that's certainly one way that it can get there, but once something is in your nose, gut, or lungs, the barrier to your bloodstream is minimal. After all, if that were not the case, you would not be able to breathe or absorb nutrients from food.

Either way, the point of that comment wasn't that it gets to your digestive system through the blood, but rather that it doesn't stay mostly confined to your lungs, and can spread anywhere in your body. The lungs aren't really even the primary target/symptom area at this point.

The lungs are the direct conduit to the bloodstream, of course, but what do you think causes the clotting? The binding of the spike protein to the ACE2 receptor.

Actually, no. It is believed to be caused by the virus attacking and damaging the epithelial cells that line the blood vessels. The ACE2 receptor just happens to be how the virus gets into those cells, and that's also what makes it sometimes attack the heart muscle in young people and cause myocarditis.

That, coupled with lower bloodstream involvement in general, explains why there's no sign of increased heart attacks or strokes after mRNA-based COVID vaccination. The shots that did potentially cause clotting issues were the ones built around attenuated viruses.

If you forgot the main point I was making, it's that the vaccine platform isn't the cause of the clotting - it's the proteins it produces that mimic the virus structure.

Except it isn't, as I said above.

But even if what you're saying turned out to be correct, the virus would still do exactly the same thing, but with an actual virus behind those spike proteins. So instead of just causing your body to temporarily act like it has gotten a low dose of an ACE inhibitor and have slightly lower blood pressure, it also attacks the cells it hits and kills or damages them. Instead of rare cases of mild myocarditis from those spike proteins interacting with the heart muscle that mostly resolve on their own, you have cases of acute myocarditis often resulting in death.

Any time you have a vaccine whether weakened or mRNA, there's a chance that the symptoms caused by the virus will also be caused by the vaccine, just typically with much lower severity. And the whole point of that vaccination is to expose you at a lower level so that when your body sees it for real, it attacks it more quickly and prevents you from having those bad outcomes.

Comment Re:Don't expect too much (Score 1) 22

Most Panther Lake laptops sold for serious work and/or gamers will have an NV mdGPU in them anyway. There may be some miniPCs (which is a slowly growing segment) that rely on the full Xe3 implementation of Panther Lake for graphics. But if I recall correctly, Panther Lake SoCs will have overall better graphics compared to their Arrow Lake-H and Lunar Lake counterparts at the same launch price points, e.g. everyone who actually uses the iGPU will get better graphics with Panther Lake than they did with either Lunar Lake or Arrow Lake.

Comment Re:Britannica offers a credible example (Score 1) 87

That is really not assured. If that is an LLM, it may still get things wrong in its core competences. Yes, that will be relatively rare and since this is an encyclopedia, you can consult the actual source easily, but there no way to prevent LLMs from hallucination. It cannot be done. It can only be gotten down to a low level.

Comment Re: Not surprising... (Score 1) 87

Yep, just some self-important nil wit with no clue but a ton of arrogance. No surprise that person posted AC.

Funny thing is, I just have started a small student research project into how LLMs make code less secure. The project is obviously open with regards to results, but the evidence is already piling up.

Comment Re:What is this crap? (Score 1) 107

You mistake my meaning. Not wanting to screw you is also a degree of wanting to screw you. It is just zero. Not that I believe that for a moment, that is not how economics graduates think. But the ones you buy from may just have made that a secondary goal because they realized that making a good offer actually gets them more business. That may last or not.

Comment Re: "Mis-information" = BS Madup word ;-D (Score 1) 98

But then where do you draw the line? Is a work of fiction "misinformation" because it portrays something that does not exist, or does it get a pass because it's explicitly labelled as fiction?

It gets a pass because it does not purport to be the truth.

How about religion? Most religions describe all powerful deities and scientifically unexplainable miracles, none of which can be proven. Do we class religious teaching as misinformation too?

When religious teachings are limited to the existence of creator beings and deities and things that you can't see or interact with, no. They're just mythology. When they are limited to how you should behave at a high level, no. They're just philosophy. There are bright lines, though, like telling people how to vote, where religion stops being religion and starts being a political organization under the guise of religion, and that's not okay.

It also starts to become very grey when religious leaders advocate things like vaccine refusal, because that can cause public health crises, like the rather alarming measles outbreak in Texas. I would argue that doing so is crossing a line, because as was proven in that case, even the relative isolation of a religious community is not adequate to prevent a lack of vaccinations from causing a major public health crisis across multiple counties.

Then there are other cases. Consider new research that contradicts previously established research? This happens all the time as science advances. Should a scientist's new theory be immediately discredited without giving it an opportunity for peer review and further research simply because it seeks to disprove some earlier research?

Depends. If the scientist's theory provides robust evidence, was authored by someone without a history of publishing fake papers and who has no ties to anyone with such a history, uses math and research methodologies appropriately, and has been published in a peer-reviewed journal that is appropriate for the subject area, then it should be followed up with additional studies to figure out why there is a conflict between the previous studies.

If the scientist's theory provides little more than a different way to manipulate the numbers from other studies (metaanalysis) in ways that contradict scientific consensus, with no new data, was authored by or edited by someone who has authored multiple similar papers that attempt to push a similar viewpoint, is filled with blatant methodology errors that should be obvious to a second-year college student in the sciences or social sciences, and is a medical article published in a physics journal, it should be immediately discredited as complete and utter garbage.

There is a point in the middle beyond which it makes no sense to give something the benefit of the doubt.

When a scientist is repeatedly falsifying information or repeatedly using poor scientific practices with obvious methodology errors or misunderstanding the basic science of what they're talking about while writing a paper filled with pseudoscientific bulls**t in a way intended to fool lay people who don't understand the science into believing it, that's disinformation.

When a journalist reads such a paper and promotes it as proof that their preexisting opinion was right all along, that's disinformation. When this is further fueled and amplified by professional chaos mongers in Russian troll farms, that's disinformation.

Finally, if the "proof" of something is published only in a YouTube video or similar, that one factor by itself is enough to guarantee that it is garbage without even considering any of the other factors above, because it means what they are saying is so obviously false that if someone read it on paper, they would immediately call the author a moron, but they're hiding that tiny bit of dubious information, spread across a one-hour video, because baiting the audience will get more views on their channel.

Science needs healthy debate, it needs people to challenge established facts either to prove or disprove them.

It does. But the key word here is *healthy*. And part of that requires everyone involved in the conversation having a proper understanding that the vast majority of papers that go against the status quo turn out to be incorrect, either because of methodology mistakes (honest) or because of falsified data (fraud). As long as the folks reading the papers read it with a healthy skepticism, it's fine.

Where it becomes a problem is when a few researchers repeatedly and intentionally create multiple similar dissenting papers with similar flaws, getting retraction after retraction, in an apparent effort to mislead, and then people latch onto those papers as truth and ignore the retractions after major flaws are pointed out, or worse see the retractions as proof of some kind of conspiracy to hide the truth.

Where it becomes disinformation is when people start cherry-picking those dissenting papers, ignoring the mountain of evidence that contradicts those papers, and using only the cherry-picked papers to claim that their fringe viewpoint is the truth and everyone else is wrong. And unfortunately, a certain subset of the media, influencers, etc. were very much doing that, and it got out of control.

That's not healthy debate. That's Fox News and one side shouting over the other, reinforcing people's preconceived notions. That's the opposite of healthy debate, and resulted in people being the opposite of healthy, which is to say, dead from COVID.

Comment Re: misplaced quotation marks (Score 1) 98

As to the "valid reasons to not get vaccinated", I aleady gave you one: because everyone's own body os everyone's personal decision first, and any other consideration a distant second.

I mean yes, ostensibly, but the flip side of that is that a functioning society requires people to do certain things for the good of society that they often don't want to do. Obey the speed limit. Send your kids through a properly accredited school system. Pay taxes. Vaccination is no different.

At this point, we let COVID get out of control by ending lockdowns too early and not taking adequate steps to isolate people with severe immunodeficiency to ensure that they did not become variant manufacturing plants, so further annual vaccination provides limited public health benefit, and mostly serves to protect the individual, with the possible exception of mandates among healthcare workers who work around the elderly. The same is true for the flu shot.

But that is not true for vaccinations in general, and it is also not really true for the initial vaccination, because allowing your kid to die from COVID or grow up without a parent because you did is at least arguably child abuse, and has a very real societal cost. So it is entirely within the scope of governments' interest to mandate vaccinations for certain diseases if you want to be a part of normal society, e.g. requiring your children to have vaccinations before they start school.

Comment Re:Again this is not true (Score 1) 98

So whereas the vaccines might cause a little short-term inflammation in the heart that goes away covid causes noticeable long-term damage.

To be clear, the base technology of the vaccine is not the likely cause, but rather the spike protein created by the mRNA that binds to the ACE2 receptor - an effect that also happens with the real virus except mostly in your lungs because it's not injected.

The real virus does not stay confined to your lungs, nor even mostly confined to your lungs. Viruses start by attacking the epithelial cells in your nose, mouth, and lungs, but then they quickly spread throughout your body.

Why do you think one of the most common first symptoms of COVID (*before* respiratory symptoms) is diarrhea? Do you think that your lungs just magically asymptomatically swell and push against your intestines? :-)

One of the best ways of tracking the true rate of COVID spread is through sewage testing. You can detect how much COVID virus shedding exists in the sewage and use that as a very good indication of how many people are actively infected with COVID in a region. This has been used almost since the beginning of the pandemic.

COVID causes muscle aches. COVID causes brain fog and neurological disorders sometimes. COVID causes myocarditis and pericarditis at an alarming rate in young people. COVID causes blood clotting that leads to strokes and heart attacks. COVID causes wound dehiscence.

No, COVID absolutely does NOT stay mostly in the lungs. Whoever told you that was so full of s**t that they may need emergency surgery for a bowel obstruction caused by craniorectal inversion.

Comment Re: You're just trying to bait the conversation Tr (Score 1) 98

Gosh, I had been told that the US election system was perfect and beyond critique. But what you are saying is that it is open to all kinds of mischief.

Literally nobody in his or her right mind has ever said that. What they have said is that cases of actual voter fraud (defined as voting without being eligible) are extremely rare and that the vote counting system is reasonably robust against interference with the actual vote counting process.

But the entire system still depends on people deciding to vote, and can easily be skewed by factors that dissuade people from doing so, like using voting machines that keep breaking, resulting in longer lines at the polls and people having to give up and go back to their jobs.

The #1 reason this is possible is because election day is not a mandatory nationwide holiday as it should be.

The #2 reason is that they don't require polling places to look at the length of the line and when it gets longer than about ten people, and start telling the people at the front of the line, "You can either wait for a booth to open up or I can stamp a provisional ballot with my 'voter verified at polling place' stamp, and you can go out to your car, fill it out, and bring it back to me any time before [closing time]. You don't have to wait in line to return it." They already have the provisional ballots, so this would be pretty close to a zero-cost, zero-effort change that would have no meaningful impact on voter fraud, but would prevent long lines from disenfranchising voters.

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