There are two parts to this:
1) Get the RNA into the cell in the first place. Anything you want to get into a cell has to pass through the cell membrane, and if the molecule is any larger than H2O, the only way to do that is with a transport mechanism you would find within the cell membrane. In this case, the transferrin receptor that transports Fe from the bloodstream to the interior of the cell.
2) Cause the transcription interference in the DNA itself, as described by the GP. At this point, the transferrin receptor is no longer at issue. While normal cells will definitely uptake the RNA, the idea is that normal cells won't be affected by it because it is designed to interfere only with RRM2, a cancerous mutation.
The information is out there freely available.
Yeah, except for these quite high barriers to entry, yes everyone can go about fixing other people's code.
I can't imagine how you could set the barriers any lower....
Compared to most barriers in life they're right down there with the rats leaping over them joyfully.
Because everyone is a programmer, right?
Everyone with the desire to be a programmer, a bit of time, a bit of willpower, a working brain and a net connection.
So sure.
Not everyone.
And everyone is intimately familiar with everyone else's code bases and every library, UI toolkit etc that are also used, right?
yes. people are not omniscient. it's true.
Context is all. Would you call the police against Charles Fox and Norman Gimbel because they are killing softly Roberta Flack with their song?
When a mortuary science student says publicly on a blog that she is "looking forward to Monday's embalming therapy" it's obvious she is talking about her monday's class.
The context is there as well. Her other posting says "I still want to stab a certain someone in the throat with a trocar though. Hmmm
Keep in mind that earlier this year we had a mentally unstable student charged with murder. The offense? Poor lab protocol. So, a college student going off the rails isn't unprecedented. I see no harm in a little additional caution when an already stressed (by nature of university) college student is having violent thoughts or fantasies and is looking forward to their next classroom time with sharp instruments. She has the chance to appeal, as well.
Eminent domain is not a right, it is a power. Governments have powers, individuals have rights.
And when your house is condemed, what exactly is the difference? I understand your point, but its unnessary nitpicking, because it doesn't change the fact that the government can do it.
And as I have been saying - legal authority is not moral authority. The USC has its imperfections, but it's what we have.
Ya, so we should not be able to have a civilization because a few people can't be happy in another home? Checkout the Woodhaven Expressway, it's what happens when a few selfish people block improvements that would benefit many.
Wrong.
The only way to be sure is to nuke it from orbit.
Have a nice day.
Or you may have
- poor apps whose layout breaks at low DPI
- poor apps that don't resize icons for lower resolutions
- apps that down-sample resolution poorly
etc.
And so people should run their screens at high resolution. Not.
The point is that you shouldn't have to change your resolution or worry about resolution or its affect on your apps. The OS should put the resolution at an optimal value for the monitor that you are using. That's what Fedora does for me.
A GUI or app that assumes a fixed resolution or font size is a poor app. If you don't use or buy them they will go away.
It's really a matter of how well your needs actually match the design. In some cases the price is worth it (or even necessary). In other cases where your requirements for accuracy, reliability, or ease of use are much less than the design goals, it's an outrageous price but the lower cost part with the looser design constraints doesn't exist. That's when it's time to get hacking.
Not true. You spent a significant amount of money developing the other 399 that didn't get approved.
Ya'll hear about the geometer who went to the beach to catch some rays and became a tangent ?