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1/5 of All Human Genes Have Been Patented 441

mopslik writes "A story on National Geographic News cites a study claiming that 20% of all human genes 'have been patented in the United States, primarily by private firms and universities.' While universities hold 28% of all gene-related patents, 63% belong to private firms, with a whopping 2000 patented genes (approximately 67%, or 50% total) belonging to a single firm." From the article: "You can find dozens of ways to heat a room besides the Franklin stove, but there's only one gene to make human growth hormone ... If one institution owns all the rights, it may work well to introduce a new product, but it may also block other uses, including research ..."
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1/5 of All Human Genes Have Been Patented

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  • by InsideTheAsylum ( 836659 ) on Friday October 14, 2005 @03:50PM (#13793106)
    I thought it was a joke that you can patent genes, but I guess it's for real? Wow, that's a real shocker, but it brings up a question, how can you patent something that you didn't invent and what can you do with this patent? Does this mean that 28% of my er.. body belongs to someone else?

    Basically a dumbfounded, "Wh...whaaaaat?"
  • Facts? (Score:5, Interesting)

    by Puls4r ( 724907 ) on Friday October 14, 2005 @03:54PM (#13793158)
    What ever happened to the idea that you can't patent facts? Discovering WHAT they do doesn't mean you invented them.

    If I discover a new element, can I patent it? Can you imagine if someone patented, say, Gold?
  • Re:Correction (Score:5, Interesting)

    by Impy the Impiuos Imp ( 442658 ) on Friday October 14, 2005 @03:54PM (#13793162) Journal
    On the other hand, in 17 years they will all be free game again. More likely than not not too much will be able to be taken advantage of before then.
  • by Anonymous Coward on Friday October 14, 2005 @03:57PM (#13793212)
    Hey. It looks there are two genes ... GH1 and GH2.

    Some cut'n'pastes from http://www.ncbi.nlm.nih.gov/entrez/ [nih.gov] ...

            Official Symbol: GH1 and Name: growth hormone 1 [Homo sapiens]
            Other Aliases: HGNC:4261, GH, GH-N, GHN, hGH-N
            Other Designations: pituitary growth hormone
            Chromosome: 17; Location: 17q24.2
            GeneID: 2688

            Official Symbol: GH2 and Name: growth hormone 2 [Homo sapiens]
            Other Aliases: HGNC:4262, GH-V, GHL, GHV, hGH-V
            Other Designations: placenta-specific growth hormone; placental-specific growth hormone
            Chromosome: 17; Location: 17q24.2
            GeneID: 2689
  • genes or alleles? (Score:4, Interesting)

    by G4from128k ( 686170 ) on Friday October 14, 2005 @04:01PM (#13793253)
    Does anyone know if these patents cover genes (a particular location on the DNA) or alleles (a specific variant that this found for some gene) [wikipedia.org]? If the patent covers a specific DNA sequence, then it is an allele. If it covers an allele, then the number of possible patents is much larger than the number of genes.
  • by evil_robot_ted ( 922967 ) on Friday October 14, 2005 @04:25PM (#13793504)
    I'm a fourth year molecular biology grad student, and the proteins I've chosen to study have been limited to only my imagination. I don't understand the business end of this prospect. Just last week I read that a certain protein is not expressed in the cell line I'm studying. To obtain that protein, I had the freedom to purchase the gene ligated into a commercial plasmid from a number of companies. But since the cDNA of this protein could fairly easily be amplified from any donor tissue, how can a company with a patent stop me from using it?

    As a scientist, am I supposed to pay somebody to use it? I don't think so.

    Though the article isn't clear about it, I think this only applies to people who intend to use certain genes for bioremediative therapy of some sort - for profit. This does not seem to affect the scores of scientists researching the patented genes. So research won't slow down, but the marketplace for any beneficial applications might. (But with the lag of the FDA anyway, what else is new?)
  • by Guppy06 ( 410832 ) on Friday October 14, 2005 @05:00PM (#13793836)
    Where were all the "Intelligent Design" Republicans during this? If there's a designer, then it's all prior art, so why isn't the GOP stepping up to the plate on this?
  • Re:Correction (Score:3, Interesting)

    by Znork ( 31774 ) on Friday October 14, 2005 @05:08PM (#13793902)
    China's just playing catchup; when they reach technological parity and surpass the US they'll join the enforcement team and make the current offshoring look like paradise. Imagine the glee with which the future patent holders will suck every drop of available capital out of our insurance systems.

    Intellectual property is in its actual essence a corporate taxation and welfare system without borders. It's rather mindboggling to see elected politicians handing out rights to (foreign) entities to basically tax buisnesses and citizens in the various countries, and to do it without demanding anything in return.
  • by Irish_Samurai ( 224931 ) on Friday October 14, 2005 @05:21PM (#13794006)
    OK, I'm not saying this is right, but here is the stance.

    Monsanto created a seed (let's say corn) with special characteristics in it, therefore the seed is theirs to use. This would be parallel to the isolated gene and a derived use for it.

    There is natural cross pollenation that occured. This is parallel to two people having sex. One person may have the gene that has been isolated and used in a patented process. If one of the two people had the parallel gene+derived use and they could have passed it on during reproduction. Monsanto didn't patent the seed for plain corn, they patented corn seed that was created using their process, a process that gave it a special characteristic. This special characteristic was passed during cross pollenation.

    Now, the newly cross polinated corn produces seed. Just as the reproducing couple created a child. This child may have inherited some characteristics of the parent who used the patented gene. This is also true of the newly created corn seed. It may have characteristics of the Monsanto seed that cross pollenated it.

    Here's where it gets tricky. No one would sue the the parents because the child had these special characteristics in it, but they would sue the parent if:
    • The parent tried to sell their DNA in an attempt to profit from having this specialized trait.
    • Or the parents tried to sell the childs DNA to profit from it having this special trait.

    The farmer whose crops were cross pollenated harvested the seed and replanted it. The farmer may or may not have known the new seed he harvested contained special propertes, but if it did - Monsanto felt he should have to pay for the seed or purchase new seed without the engineered trait in it. This parallels the parents selling the their trait laden DNA for profit, which probably never would have gained that trait without the processes influence.

    The parellel breaks down at the point where sex can be controlled and cross pollenation, for the most part, cannot, but who needs to bicker about specifics when you're a big multinational corporation? Who's sueing a friggin farmer.

    The REAL reason Monsanto would sue that farmer would be so that the Monsanto sponsored farmer could by his land, with Monsanto's help. In exchange the farmer who aquired the new land would have to sign a contract stating they would purchase Monsanto seed exclusively for all their crops - but didn't set a price. Then Monsanto jacks the cost to that farmer just enough to fleece him indefinitely, but not enough to put him out of business.

    PROFIT!

    BTW, don't drink milk - Monsanto went and fucked that up too. [google.com]

  • by TheSync ( 5291 ) on Friday October 14, 2005 @05:24PM (#13794028) Journal
    Here is an example of a "Gene Patent" Nucleotide sequences which code for the menE gene, United States Patent 6946271 [freepatentsonline.com].

    It really looks like most of the claims are about the sequence, not any particular utility for it! Of course, it does say what the proteins that the sequence codes for is and does.
  • by RexRhino ( 769423 ) on Friday October 14, 2005 @05:34PM (#13794098)
    All drug development is for profit. All institutions need to bring in more resources than they consume (or the institution collapses). The difference between the value of the services they provide and the value of the resources they consume is profit. Natural selection applies to everything, so institutions that make a profit survive and thrive, institutions that don't fail and go away... natural selection leads to profit making organizations, no matter if they choose to call themselves profit-making or not. You are not arguing against a profit system, but that we should change the profit model of drug development from a competitive market system in favor of a government controlled monopoly system.

    While I agree, information about the human genome should be free to be used by everyone without cost (the patent system wasn't supposed to help the patent holder make a larger profit, but just enough to cover the cost of development of the patented technology), I fail to see how a monopoly system is more efficent than a more decentralized system? There are historical cases we can compare for a market profit model vs. monopoly profit model on the effect of health care. For example, if the monopoly profit model is the best, we would expect the Soviet Union and Eastern Europe during the cold war to have better health care, higher life expectency, etc., than in Western Europe, Canada, and the United States (drug development in the U.S., Western Europe, and Canada were not really a true market system, the governments of all spent billions on research, but they were far more free-market than the Soviet system). But I am afraid you will find that health care in the West was better than in the East.

    It is going to take more than just showing us that the market isn't producing some drugs that people need (because clearly Cuba and North Korea aren't producing those drugs either, which they should be if a government controlled monopoly on drug development was the be-all end-all solution to drug development)... why don't you show us how your profit model for drug development is better for consumers that the current profit model?

    Show us why one big heirarchical drug development system is better than a decentralized network of drug development.
  • by Dr_Barnowl ( 709838 ) on Friday October 14, 2005 @06:33PM (#13794476)
    You hit the nail right on the head :

    "The Market" gives arise, by darwinian evolution, to entities that are the most efficient at extracting profit.

    This has nothing to do with peoples health.

    By all means, make the buggers compete with each other, but not for profits ; make them compete for number of people healed. Or whatever.

  • Re:Correction (Score:2, Interesting)

    by cas2000 ( 148703 ) on Friday October 14, 2005 @11:01PM (#13795593)
    pharmaceutical companies have avoided the need to purchase^Wlobby for extensions of patent law terms by use a technique called 'evergreening' - they just apply for a slightly different patent for the same chemical or gene, shortly before the current patent is due to expire.

    a patent can be kept "valid" for decades in this way.

    try a google search for "+patent +evergreen" for more info.

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