I think calling it a "war" is disingenuous. Name a single regulation that was not based on a real public need. The only one I can think of was the whole anti-pipeline thing (KXL and Dakota Access), which was just straight-up ignorant. I wouldn't call that a war on businesses, though. In fact, my company made money off of TransCanada due to that debacle.
Compare that to what we have now, though. The president can cause stock prices to drop 5% or more with a single vindictive, vapid tweet. Obama's administration could lay out a damning white paper with detailed explanations of why mining tailings were bad for drinking water supplies, and nobody gave a shit because they knew the Republicans in congress would never actually do anything about it. God forbid we have an EPA or OSHA that actually, you know, defends we the people.
I'm pretty pro-Tenth, but honestly how are you going to handle river pollution at the state level? Is Louisiana really going to tell Texas to keep their cadmium on their half of the Sabine? Air pollution: can Arizona tell California to get its cars off the road when the wind is blowing? What about global warming? Anything requiring an international treaty is by definition a federal issue.
I'm tired of people claiming that all regulations are anti-business, and that all businesses just want to screw people for a buck. There's a real benefit to the American people when a smoothly functioning federal government does it's job. Also, there are real financial incentives when businesses act ethically. Unfortunately we haven't seen either in so long, most people have forgotten what it looks like.
"Show me a good loser, and I'll show you a loser." -- Vince Lombardi, football coach