While they're currently only applying this to people with extreme cholesterol problems, there's no reason the same treatment wouldn't work for anyone on statins. They use different dosages to impact a different percentage of the liver cells to adjust cholesterol levels, essentially introducing a mutation found in a small percentage of the population where a particular gene is inactive. For people with more manageable cholesterol levels, they would presumably just need a lower dosage to get levels below that where medication is required.

So for now, this will likely be only used in extreme cases, but over time, this could be an alternative to statins just like lasik is an alternative to glasses.

I would love to stop taking my statins, and I'm sure many other people would also opt for something like this. Once they get more experience in the more extreme cases, there's every reason to believe they'll open it up for wider usage. Apparently between 50% and 65% of people fail to take their statins consistently for various reasons, so this could be much more effective and reducing heart disease.

They're effectively introducing a rare genetic mutation. They found some people who have extremely low cholesterol, and it's due to one broken gene, so they introduce that change in some percentage of the liver cells to reduce the cholesterol levels. They can do studies of people who already have the mutation naturally to get an idea of any expected health impacts.

I think you're misunderstanding the point: there's a lot of FUD about BE vehicles in north america, not least of which is that battery fires are common, and they may burst into flames at any point. There have been some high-profile examples of badly designed or built cars killing people or lighting on fire, etc. As one would expect, the number of ICE vehicles that this happens to is greater because they're still a larger proportion of all vehicles. But also, as a proportion of their type, more ICE vehicles spontaneously combust than EVs.

The point is that this is not an issue with BEV technology.

Indeed, the intro to the vehicle even says as much:

Emphasis mine.

Yeah, you're not understanding what I'm saying: Azure doesn't just host Linux VMs, significant parts of the infrastructure are built on Linux. Microsoft has just as much (if not more) to lose from a resurgent SCO lawsuit than anyone, they aren't going to be the ones rocking this boat.

One could argue that no one is doing it in six days without a shit ton of automation support. Some cherubim in ops saved eons when he wrote createstar.pl and it's still running in production today (though it looks like creategalaxy.pl stopped executing some time ago and hasn't been restarted and/or patched yet).

This was a reasonable screed two decades ago (and probably at least somewhat factual) but today Microsoft is one of the world's largest users of Linux. It has no current motivation to harm Linux and every reason to defend it.

Y'gotta stop cutting education and vaccine funding.

Freedom of speech exists exactly BECAUSE speech is dangerous, particularly to entrenched powers.

The reason why it's enshrined in constitutions is because the people that wrote those constitutions wanted the citizens to be in charge, for them to push back and reform governments when they went astray. Protesting and reporting are usually especially enshrined because we know that without those rights, the people are oppressed. The first thing that goes when authoritarians come in is an abrogation of those rights, SPECIFICALLY because authoritarians know that free speech is inherently dangerous to their grasp on power. Only by keeping people in the dark and spreading propaganda can they retain their hold on power.

We saw it happen with Trump and Fox News and all of his toadies buying up TV stations and news networks. If speech isn't powerful and dangerous, then why are so many people concerned with the ability to control it?

And yet, even in these societies with free speech, there have also been limits put on it, because there's no way to run a society with unfettered free speech. We've long since decided that libel and slander are illegal, you can't make threats of physical violence to other people, conspiracy to commit [some crime] is itself a crime.

So I dunno man, how is it that you think that there's no such thing as hate speech? A violent threat can send someone into hiding very nearly as effectively as actually attempting the violence. It was just speech, but it still had an effect. Can you really possibly believe that words have no weight? That speech has no consequence? Have you never read any history, particularly of charismatic cult leaders or politicians?

People are spurred to action by words all the time, and you can't just dust your hands of it and say, "hey, I was just saying words over here that made them believe that that guy was coming to kill their kids in the night and poison their water and salt the earth. Of COURSE I was as convincing as possible and they believed me and attacked him, but that has NOTHING to do with the things I said!"

Your claim is absurd on its face. There's literal millennia of evidence.

My company instituted it because it was too hard to compete on salary alone. I make a bit less per year, but my hourly rate is now higher.

It's been an amazing experience. 4 days a week is more than 20% better than 5 days a week. I'm excited to work on monday, I don't feel like I've been through the wringer on thursday. I would guess that averaged over a whole year, I get at least as much work done on the 4DWW, though for shorter periods of time, 5 days WILL generate more work (much like crunch will also generate a lot of work in a short amount of time, but as it goes on, productivity drops).

But 4DWWs have nothing to do with AI. We mostly don't use it (I work in games; the discussion is fraught, so we mostly just don't use it at all, and most of us at the company want very little to do with it) and our productivity is just fine.

Something that I think a lot of people miss, particularly with programming, is that when you use agents, you effectively make programmers into managers whether they want to be or are good at it or not. Making programmers outline broad tasks and review the results and iterate without writing code themselves is manager work. It's all the worst parts of programming and none of the stuff that we actually like. And not everyone wants to be a manager! I'm a programming lead, and I enjoy it, but it's hard and it uses my brain in a completely different way that I would not have been interested in when I was 25. I may not have even been ABLE when I was 25.

AI doesn't relieve you of any work, it just changes the nature of the work away from the actual job description. Of course nobody's switching to the 4DWW--you just made everyone's job harder and worse, so everyone is always behind.

I work a 4 day work week. My pay is slightly lower than at my last job, but my hourly rate is higher. My company started offering it years ago because they couldn't compete on salary, but they realized that some of us would really just like a better life, and that was something they could manage.

The 4DWW isn't as transformative to me as remote work, but it's been so good for me. I'm excited to get back to work on Monday, and I don't ever feel like any part of the week is a slog. I'm happy to occasionally sit down and fix something on the weekend quickly because my brain happened on the answer while I was relaxing.

If we all must work in this capitalist hellscape, 4 days a week is much more than 20% better than 5.

There's a reason the aphorism, "the Pen is mightier than the Sword," exists. You cannot simultaneously hold that the only power is physical power but also believe ideas or ideologies are powerful. Of course they are. It's the basis of religion and politics writ large.

People can be convinced that an ideology is correct, and then do terrible things in the service of that ideology. It's not that complicated.

The reason why wealth itself is important is because wealth begets wealth. You're right that to some extent it's an under-consumption problem, but fundamentally, wealthy people use their wealth to accumulate more wealth.

And that sounds a bit tautological, but what I mean is: if you have a huge amount of wealth, the things you buy are things like property, stocks in other companies, natural resources, etc. Wealth accumulation accelerates over time. But there isn't an infinite amount of wealth to be had. There's a limit to how many homes there are, how many farms and oil wells and all those things. Governments are in debt and can't help their citizens because they no longer own big blocks of apartments, they no longer own productive land or natural resource companies. (Actually, some do, and you'll note that they're the ones that provide ongoing support to their citizens.)

Even with a little bit of wealth, you can anchor your whole life. Owning your own home is huge. Put enough money into investments, and there's a time at which contributions to your portfolio are less than the money the portfolio generates on its own. And of course, this wealth is both real and illusory; stocks have no value until you sell them, but they can serve as collateral for loans at lower interest rates, and you don't pay taxes on loans.

The rich DO compete with folks for real estate, they become landlords, which is an inherently parasitic position. Consider: a landlord buys a home and rents it out. They pay the mortgage and for upkeep, and they charge a tenant for their own costs, plus some amount of profit (or, occasionally, no profit, on the basis that land value goes up over time). If the tenant can pay this rent, that means they could own the property themselves, but there's an intermediary skimming profit off the top.

So more and more people are locked out of ownership, because the initial cost of ownership is too high, but we know factually that they could actually pay for and maintain that property themselves, because that's what the rent covers. Where does that extra money go? And what is it paying for? It's paying for nothing; the landlord is a parasite, plain and simple.

But anywhere that someone with tremendous wealth goes, the same story is allowed to play out. We've all seen the stories of these private investment firms buying up good businesses, saddling them with debt, taking all the good stuff, and then leaving the business to go bankrupt. It's wealth extraction that only rich people can do, and it destroys businesses big and small.

Ultimately, the accumulation of wealth is a de facto accumulation of power. Our politics is not SUPPOSED to be influenced by money, but it definitely is. Elon Musk doesn't need to be able to vote multiple times to influence the outcome of elections, he can just throw hundreds of millions of dollars at it--an amount he makes back in a trivial amount of time--and get the outcome that he wants.

You're right that the extremely rich use the same phones as I do, eat the same food as I do. What that tells us--what we all already know--is that they don't NEED to be that rich. They can live a life of extraordinary luxury with so much less. So my concern with wealth is that it is not created out of thin air, and there's a finite amount of it to go around. The billionaire class growing in number as well as their fortunes growing by huge amounts happening at the same time as governments running huge deficits and the middle class shrinking is not a random coincidence. One is the cause of the other. That's why when many of us talk about wealth, it's as a *transfer*, from one class to another. Billionaires are literally impoverishing the rest of us.

Whether we like it or not, whether we use Windows or not, Microsoft is going to insist on adding the tax whether the PC comes shipped with Windows or not. This is illegal bundling, Microsoft has essentially ignored prior rulings, and it's pretty much a certainty the courts will be fine with this.

"How did you get hired?"
"I was top at Fortnite. You?"
"Combat flight sims."

"Damn, two Boeings just crashed over an oil refinery on city limits and took out half the city."
"Did you remember to save your position beforehand?"
"Yeah."
"The reload and continue from there. No-one will notice."

I love computer games. I have XPlane 12 and many scenery packs. I rank well on Elite:Dangerous. From the sounds of it, the FAA would see me as over-qualified. In reality? There's no way in hell I'd be taking those kinds of risks with real lives. There's a huge difference between having good reflexes and a good eye, versus having the complex 4D spacetime relationship mental models needed for robust air traffic control.

The problem with the above is that you are mistaking "yourself" for "the market."

"Everyone isn't doing what I want them to, obviously 'the market' is broken."