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Comment Re:2352 (Score 1) 102

Sigh. Ontogeny is NOT evolution. It is not the same thing as having a low MHC diversity due to a genetic bottleneck as well as lacking tens of thousands of years of evolution to a pathogen. Not the same at all. It's silly to even suggest that. Epigenetic shifts in an individual do not create new HLA genes.

Consider COVID. Novel bat coronavirus, nobody had preexisting immunity. Did everybody die? No. Because we had high HLA/MHC diversity, making it easier to target SARS-COV-2 epitopes. Native Americans lacked this diversity. It left them ill prepared for novel pathogens.

Also, you seem to believe that any disease you've never encountered before is fundamentally dangerous to an adult. That's simply not the case. Rhinovirus is intrinsically mild. It's an upper respiratory infection; it's not adapted to lower respiratory or systemic infection. It's not ebola. It's not going to become like ebola just because you've never caught it before. If a rhinovirus strain was reintroduced after 200 years after having been eradicated, we'd all get a cold, but by and large, we'd be fine.

And what would happen if Yamagata reappeared? We'd just add it back to our flu vaccines. Furthermore, the reintroduction of Yamagata wouldn't be catastrophic without that. You do not have to catch every Influenza B lineage at all, let alone every year. If you had been infected with B/Victoria and you were exposed to B/Yamagata, you'd have little sterilizing immunity against it - you'd very likely catch it. But your past exposure to B/Victoria is still greatly protective against hospitalization and death; B and T immunity against NA and the HA stem and stalk are conserved.

And this is about whether or not to catch every lineage. Well guess what, even with air filtration, that's still going to happen. Air filtration only has a meaningful impact for people at a distance, not people close together. It's about protecting the person across the room, not the person you're standing 50 centimetres away from. What it does change is how often you catch them. And if lineages or whole viruses go extinct, that's great. Worrying about some sort of reintroduction 200 years later is just inventing your own unrealistic misery when we have actual pandemic threats to worry about.

Comment Re:The fix... (Score 1) 271

If drivers would actually stop at the solid line way before the crosswalk instead of ignoring that line hanging their bumper over the crosswalk, maybe they would see someone in the crosswalk.

No, they wouldn't, not if that someone is an average child.

But that's a small problem compared to the distracted driving car designs (infotainment screen) and young adults not looking both ways.

It is the driver's responsibility not to kill people in crosswalks whether they are paying attention or not. How many people have you driven over?

Comment Re:And that's how China surpassed American chip pe (Score 0) 63

That's not going to make China catch up to "the US" because it's not China vs the US. It's China vs. the world. Literally no country wants China to be in charge of chip production except maybe Russia, and even then only because 1) they have absolutely no hope of being competitive themselves, ever, given the way they run their country; and 2) China is still happy to do business with Russia since no one can afford to sanction them for it.

Comment Re:Truth behind doublespeak (Score 1) 74

we will see a number of really spectacular enterprise deaths and falls to irrelevance in the next few years, most with a clear trace to LLM use.

Probably, but no US automaker will be among those. The US won't let them fail because they are defense contractors. If we have a war we need them to make vehicles. The bulk of units will be drones, but we will still need tanks and whatnot.

Comment Re:Chinese cars? (Score 1) 190

Really? So, the worst and bloodiest war we ever fought just didn't happen.

No one said that. Stop making shit up.

We slaughtered ourselves to end slavery.

No, we did not. We know that's not why we did it because we did not end slavery. We only made it the sole privilege of the state. If you could read, and read the amendments to the constitution, you'd know this.

Don't f-k around.

Fuck off, illiterate.

Comment Re:Customization more important than price (Score 1) 190

It appears pretty much ALL the side panels on this thing are plastic

Vehicles normally don't have "side panels" and it's not just a cost reduction measure.

I also saw a hint on that show that in the future potential for 4-wheel drive could be an option....I hope it gets there...talk about massive custom options appearing out there for that...???

If you're willing to implement "custom options" then you could make it 4wd yourself, without any help from them, like any other pickup.

Comment Re:The fix... (Score 1, Insightful) 271

We can't educate the deer, so I suppose teaching kids to watch where they're walking and how to be safe is the best we can do.

We taught kids to use crosswalks, now drivers are mowing them down there because the hoods of their pickups are so high that they cannot see them crossing. This is all stuff you would know if you were paying attention.

Thanks for proving you're not paying attention.

Comment Re: Observational study can't claim causality... (Score 1) 271

In all but five US states you don't even need a CDL to drive a heavy diesel RV. We have a bus registered as an RV, it weighs 10 tons and has air brakes, I can legally drive it on my basic license.

Ironically, it has much better forward visibility than a modern American pickup truck, including the Japanese pickups made here for sale in the US, as it's transit style (flat front.) I can literally see people crossing in front of me that the driver of an F250 can't. And these days, the most popular school bus appears to be the Blue Bird Vision, which is a conventional type bus but has a short, sloping hood. That also has a better view of pedestrians than a modern American pickup.

It's insanity.

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