Comment Re: Democracy on a bad day (Score 1) 378
Started burning coal for electricity after shutting down nuclear.
Submission + - This frog bacterium wiped out cancer tumors in mice with a single dose (sciencedaily.com)
fahrbot-bot writes: Science Daily has reported that scientists at the Japan Advanced Institute of Science and Technology (JAIST) have identified a naturally occurring bacterium from the intestines of Japanese tree frogs (Dryophytes japonicus) that demonstrated remarkable anticancer activity in mice. The findings, published in Gut Microbes, introduce a new approach to cancer treatment that uses living bacteria to directly target tumors rather than simply altering the gut microbiome.
In a mouse model of colorectal cancer, a single intravenous dose of E. americana completely eliminated tumors, producing a 100% complete response (CR) rate. The researchers emphasize that these findings are limited to mice, but they believe the results provide an encouraging proof of concept for developing new bacterial cancer therapies.
First, E. americana directly attacks tumors. As a facultative anaerobic bacterium, it thrives in both oxygen rich and oxygen poor environments, allowing it to multiply inside the oxygen deprived regions commonly found within tumors. Once there, the bacterial population increased by roughly 3,000 fold within 24 hours after treatment, directly damaging cancer cells.
Second, the bacterium stimulates the immune system. Its presence attracted T cells, B cells, and neutrophils into tumors. These immune cells then released inflammatory signaling molecules, including TNF- and IFN-, which strengthened the immune response and promoted cancer cell death.
One of the most striking findings was that E. americana accumulated almost exclusively inside tumors and did not colonize healthy organs.
They found that the bacteria were rapidly cleared from the bloodstream, with a half life of approximately 1.2 hours, and became undetectable within 24 hours. No bacterial colonization was detected in healthy organs, including the liver, spleen, lungs, kidneys, or heart.
The treatment caused only mild, temporary inflammation that returned to normal within 72 hours. During a 60 day observation period, the researchers found no evidence of chronic toxicity.
In a mouse model of colorectal cancer, a single intravenous dose of E. americana completely eliminated tumors, producing a 100% complete response (CR) rate. The researchers emphasize that these findings are limited to mice, but they believe the results provide an encouraging proof of concept for developing new bacterial cancer therapies.
First, E. americana directly attacks tumors. As a facultative anaerobic bacterium, it thrives in both oxygen rich and oxygen poor environments, allowing it to multiply inside the oxygen deprived regions commonly found within tumors. Once there, the bacterial population increased by roughly 3,000 fold within 24 hours after treatment, directly damaging cancer cells.
Second, the bacterium stimulates the immune system. Its presence attracted T cells, B cells, and neutrophils into tumors. These immune cells then released inflammatory signaling molecules, including TNF- and IFN-, which strengthened the immune response and promoted cancer cell death.
One of the most striking findings was that E. americana accumulated almost exclusively inside tumors and did not colonize healthy organs.
They found that the bacteria were rapidly cleared from the bloodstream, with a half life of approximately 1.2 hours, and became undetectable within 24 hours. No bacterial colonization was detected in healthy organs, including the liver, spleen, lungs, kidneys, or heart.
The treatment caused only mild, temporary inflammation that returned to normal within 72 hours. During a 60 day observation period, the researchers found no evidence of chronic toxicity.
Comment Just following the Ferengi Rules of Acquisition (Score 1) 109
Rule 99: "Trust is the biggest liability of all."
Comment Re: Democracy on a bad day (Score 1) 378
I too would be tempted to riot if my government destroyed industry and caused high level of joblessness by shutting down energy production. Supposedly for environmental reasons, but only to start burning coal again. Like they did in Germany.
Comment Re: Fuck Trump (Score 1) 378
If your argument that your environmental solution is no better than status quo, then we agree in principle.
Comment Re: Democracy on a bad day (Score 1) 378
In a few years ICE cars will only be sold with special permits.
This is unwarranted optimism, except for special permits, everyone in EU, including in Germany is getting banned. Including criticizing politicians.
Comment Re: Democracy on a bad day (Score 1) 378
He does the same thing with copper. Bases it off old technology, ignores aluminium as a conductor, ignores recycling, and vastly over-estimates the requirement.
I am not familiar with other points, but this seems to be spot on. You don't replace copper with aluminum for very known reasons. Recycling for most rare materials is only theoretical, as it doesn't happen in practice, and batteries in 2026 are still currently largely just landfilled instead of recycling. So if I extrapolate from these points - Michaux is spot-on while you are confusing what ought to be with what is.
We might disagree on many points, but I think we can both agree that recycling should be much further along for all aspects of common goods - batteries, electronics, consumer plastics, etc.
Comment Re: Fuck Trump (Score 1) 378
What in my "you had other people pay for your solar panels" response is not clear?
Comment Re: Fuck Trump (Score 1) 378
What in my response make you think I don't understand what mitigation is? Be specific.
Comment Re: Fuck Trump (Score 2) 378
Your installation was subsidized and incentivized with tax dollars and above-market utility purchase rates, that in turn increased costs of electricity for everyone.
Comment Re: Democracy on a bad day (Score 1) 378
Sure we can produce enough batteries for everyone to have an EV,
Citation required.
My understanding, based on Michaux 2021 work, that there is not enough minerals to manufacture required number of EVs. New technologies that use no/less of exotic minerals, more mining, more refining, etc. would be required to achieve that goal. All of this might be doable, but transition would be multi-decade long.
Comment Re: Fuck Trump (Score 1, Troll) 378
The intelligent response here is mitigation. But that's not happening either,
Mitigation is not happening because reducing emissions was never a goal of environmentalism. The system is what it does. Environmentalism reduces energy available to an individual (and therefore reducing personal freedoms and quality of life). Therefore, this is its purpose. The fact that alternative solutions, such as mitigation of climate change or nuclear, are not seriously considered just demonstrate that.
Comment Financial negligence (Score 1) 64
When your AI agent orders 3 tons of bird seed you will be solely and personally responsible for this.
Comment Re:$1,999 for a phone? (Score 1) 68
Yes, it rather slow, but I don't really need more. SE is good enough for occasional video call, email checking, etc. I have stationary PCs to do compute-intense tasks.
Comment Re: Democracy on a bad day (Score 1) 378
Can we produce enough EV batteries to switch all transportation to it? As of today, call for EV-only transportation means that personal vehicle ownership becomes impossible. To put it differently, you can drive your EV only because other people drive ICE.
