Edge Online has a short blurb mentioning a project at the University of California turning the Guitar Hero guitar into a real instrument
. From the article: "For the final project of their Computer Audio course, University of California students Travis Chen and Sunny Chan have created Guitar Hero Hack, a plugin for sequencing software Max/MSP that lets players assign switchable banks of samples to each of the controller's buttons, utilizes its tilt switch as a way to clear current audio on any given track, and, the two hope, might be on its way to a fully functioning live instrument."
His incredibly impressive demo video
is well worth watching.