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Comment Pop Culture meets religion (Score 1) 156

In the 1978 film Midnight Express, during the famous "Section 13" (the mental ward/psychiatric wing) exercise scene, the prisoners are forced to endlessly walk in a clockwise direction around a central stone pillar, which they refer to as "the wheel."

Because Muslims perform the Tawaf (the ritual circumambulation of the Kaaba in Mecca) exclusively in a counter-clockwise direction, walking clockwise is presented as a symbolic inversion of their sacred practice.

When the protagonist, Billy Hayes, realizes how mindless and soul-crushing the clockwise routine is, he defies the prison's unspoken rule and aggressively begins walking counter-clockwise, literally "against the wheel" and into the oncoming traffic of the other inmates. Therefore, the direction the prisoners were originally never supposed to go...and the direction Billy uses to break his compliance...is counter-clockwise.

Comment Re: This is already a solved problem. (Score 1) 58

The real punchline is that if you just let the DXM metabolize into DXO, it's still so weak compared to other NMDA receptor antagonists that it barely matters unless you're super sensitive to it. The 2D6 inhibition is basically a gimmick that allowed big pharma to turn an OTC miracle antidepressant into an expensive prescription product.

Comment Re: This is already a solved problem. (Score 1) 58

Do you have a point? Yeah, somebody developed a problem while self-medicating with something that has only recently been considered to have meaningful therapeutic value,* I'm shocked. The woman you're judging was basically a citizen scientist by accident because conventional psych care sucks.

*This is not an ass-pull; guess what the actual effective ingredient in Auvelity is.

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