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Comment Re: This is already a solved problem. (Score 1) 58

The real punchline is that if you just let the DXM metabolize into DXO, it's still so weak compared to other NMDA receptor antagonists that it barely matters unless you're super sensitive to it. The 2D6 inhibition is basically a gimmick that allowed big pharma to turn an OTC miracle antidepressant into an expensive prescription product.

Comment Re: This is already a solved problem. (Score 1) 58

Do you have a point? Yeah, somebody developed a problem while self-medicating with something that has only recently been considered to have meaningful therapeutic value,* I'm shocked. The woman you're judging was basically a citizen scientist by accident because conventional psych care sucks.

*This is not an ass-pull; guess what the actual effective ingredient in Auvelity is.

Comment Re:good (Score 1) 58

Emotion and culture have nothing to do with it. The government studied psychedelics extensively in MK-ULTRA, and when they found out they usually do very much the opposite of what they wanted, they decided that we couldn't have them without a huge fuss and making sure dosage is controlled to have as subtle an effect as possible. You either get barely half of a nothing or you get blackout, no talking to aliens allowed.

Comment This is already a solved problem. (Score 1) 58

Dextromethorphan is available over the counter, and at the dose that's supposedly for suppressing a cough, (which it is clinically proven it does not do) it is a very effective antidepressant with practically no side effects after the first couple weeks. Because it's so weak compared to other NMDA receptor antagonists, you can dial in a very precise macrodose for anything from "I just think music is great" to "time loops" to "talking to the god in your head" to "kissing the void." It lasts six hours and has more of a body load than other such drugs, so it's not always fun, but if you need the vision quest kind of neuroplasticity, you can get there dirt cheap, completely legal, and very safely. You can also just take the normal dose twice a day and hold your suffering much more lightly.

The main problem is finding it without tylenol or antihistamines added. These days you usually have to order it online to get it pure.

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