So, what in AmiMojo's post mentions the Federal Government?
FWIW, yes, since the mid-nineteenth century, after the creation of railroads and the adoption of a national currency, the Federal government has had power over virtually all commerce due to the fact it's allowed to regulate interstate commerce, and the things I just mentioned makes all commerce effectly interstate. I know it's not a popular thing to say, but things change. This changed 150-200 years ago and yet there's always someone who thinks that the government doesn't have the right to regulate something the constitution now gives it the power to do.
Want to change that? Either amend the constitution, or put up real barriers between the states.