I can back this up -- I have been using Comodo for over a year after switching from AVG, and have had great success. I've switched my family over as well, and the virus complaints have gone way down.
On top of that, I've started recommending Comodo for clients of mine, and they have been thrilled with the result. The smaller memory footprint alone makes it an easy sell over AVG.
Aside from one nasty upgrade bug last October, it's been a huge improvement.
Let me put it this way -- it made me stop thinking about anti-virus software. Isn't that the whole point?