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Comment I don't see how that could possibly work (Score 1) 82

TLDR version: "Good ideas" that are actually good are rare, more often than not they aren't.

Long version:

Now, that's not to say people can't experiment with ideas. We know, from US research, that you can temporarily (2 hours max) put humans into a dormant state and revive them successfully. It's used in some types of operation, when a beating heart is not a viable option.

If you do that, glucose uptake drops significantly in regular cells but not in all types of cancer. If the decrease in the most-active of human cells after hibernation is by a factor of X, then it follows you should be able to locally increase glucose-based chemotherapy around the tumour by a factor of X and guarantee healthy cells remain inside levels they can tolerate.

Since hibernation of this sort involves removing all blood and replacing it with a saline solution, washing the chemotherapy out would obviously be possible before reviving the person.

Would this work? Well, it'll work better than bleach, but a quick sanity check shows that this method is (a) impractically risky, (b) likely problematic, (c) likely to produce disastrous side-effects, and (d) unlikely to be effective. Shutting down the body like this is not safe, which is why it is a last-ditch protocol.

What does this tell us? Simply that "good ideas" on paper by someone who isn't an expert are likely very very bad ideas, even if "common sense" says they should be fine.

Now, there ARE cancer treatments being researched which try similar sorts of tricks to allow ultra-high chemotherapy doses, by actual biologists, and those probably will work because they know what they're doing.

Translation: No matter how good you think an idea "should be", it probably isn't. There will be exceptions to that, but you should always start by assuming there's a flaw and look for it. If the idea is actually any good, it'll survive scrutiny and actually improve under it.

Avpidimg confirmation bias is hard, but if you persist in looking for what is wrong with your idea and then try to fix the issue, you'll either avoid penning yourself in a corner or argument-proof your vision. Either way, you're better off.

Comment Re:Fast track this (Score 1) 82

Actually it's not certain that would always make things worse, and it should work...if the tumor hasn't metastasized.

Not really. Attacks on tumors often trigger metastasis. Useful choices are removal of the whole tumor, burning out the whole tumor, or poisoning it in a way that will also affect the mets. Any partial local attack that is likely to just make the tumor spread.

Comment Ah, now it becomes clear (Score 3, Funny) 69

On Thursday, Lutnick told CNBC that TikTok would stop operating in the US if China and TikTok owner ByteDance won't sell the app to buyers that Trump lined up, along with control over TikTok's algorithm. Under the deal Trump is now pushing, "China can have a little piece or ByteDance, the current owner, can keep a little piece," Lutnick said. "But basically, Americans will have control. Americans will own the technology, and Americans will control the algorithm."

I guess I should have seen that coming. I assumed Trump was only waiting for a kickback... but he also wants personal control over what people see, going forward. I am shocked. SHOCKED!

Comment Re:In other words.... (Score 4, Insightful) 74

Yeah, you are spot-on. From the point of view of the employees, at least, that letter must seem pretty tone-deaf... AT BEST. But frankly, it seems pretty obvious the only thing Satya is intending to say to current employees is exactly what you stated - you may be next.

This part, near the beginning, really stood out...

I want to express my sincere gratitude to those who have left. Their contributions have shaped who we are as a company, helping build the foundation we stand on today. And for that, I am deeply grateful.

Excuse me - "those who have left"? Don't you mean those who were fired or laid-off, Nadella? They weren't exactly given a choice...

Comment Re:Nonsense. (Score 1) 73

2500 steps is literally "existing as a human" unless you're bed-bound.

Yeah, I went back and looked - even on those work-from-home days when I'm more sedentary than I should be... I'm still typically hitting 3000-4000 steps. A trip to the grocery store or mowing the lawn bumps me up over 5000.

And to be clear - I don't think what I'm doing right now is adequate, I do believe I should be more active than I currently am.

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