From the interview: "The reason that Skylab wasn't build like this is kind of a strange story: [NASA] had fewer Saturn IBs than they had Saturn Vs, so von Braun just decided to use a Saturn V and fly up a "dry" lab, with all of the equipment aboard it already."
Um, not quite. When a 'spare' Saturn V became available (because a lunar mission was cancelled), they swapped from a IB 'wet' lab to a V 'dry' lab because the 'wet' labs were very expensive for their very low capability. The expense came from needing to have considerable amounts of structure and infrastructure designed to survive inside the cryogenic conditions inside the tank, from redesigning the tanks to serve a dual role, and then re-certifying the whole deal for flight. The low capability came from the requirement that everything that couldn't survive a bath in deep cryogens having to be manhandled into place via the very narrow docking hatch. While a dry lab was more expensive than a wet one - the leap in capability was far greater than the leap in cost.
That's also why NASA built their ISS modules with the large CBM hatches - manhandling large amount of stuff through tiny hatches (like those the Ixion will use) simply isn't very efficient. (And that's without considering the headaches that splitting all your equipment down into tiny chunks brings. Not just handling - but installation and integration too.) All of the ISS cargo craft that NASA is responsible for uses CBM, as does the Japanese HTV.
"In the commercial sector, it's getting interesting, because people are taking more risks. Not unnecessary risks, but acceptable risks to reduce costs."
Moving your man hours (outfitting the module) from expensive ones on the ground to hellishly expensive ones on orbit is not a recipe for cutting costs. Especially since you still have to pay for the launch of the module (Centaur) *and* the launch of the stuff to go inside it. (You can't piggyback because no Centaurs are headed anywhere near the ISS.) Even in lower inclination orbits, the mission module, the rendezvous systems, and outfitting the Centaur to survive years on orbit are all going to cost money and cut into it's payload - which will make piggybacking unattractive to Centaur's usual customers.
"We want to keep hardware costs as low as possible: it's not about building something on the ground that could cost hundreds of millions of dollars. Why do that when you have perfectly good hardware going to space, paid for already?"
You don't have perfectly good hardware going to space already. You have a vehicle designed for a completely different purpose and completely lacking the "stuff" customers will pay you for going to orbit.
Or, in short, nothing in the article or interview leaves me with a warm fuzzy that they've solved any of the well known problems with 'wet' systems.