I did exactly this, using Qubes at home. It took a little getting used to, but once you get the hang of it, it makes sense. It greatly reduces the risk of things like XSS and browser exploits leaking banking or other important information. I don't particularly consider myself the enemy of any state, but the increasing number of drive-by exploits targeting Joe Nobody for the purpose of extracting money (whether ransomware, stealing card numbers, whatever) makes this a reasonable course of action even for people not participating in espionage or whatever.
Shame that trying to game in a VM sucks hard, but that's the tradeoff.