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Comment Re:Who's Who? (Score 1) 16

TIL somebody, somewhere is still making Android tablets.

Lots of companies, actually. Nearly everybody I know buys them for sheet music. Early adopters still have iPads, but the Android tablets have gotten good enough to do the job and cost less than a fifth as much as the 13-inch iPad Air. So there are two types of people — the ones who want a nice tablet, who spend the extra for an iPad Pro, and the ones who don't care, who buy something that costs $160 on Amazon, knowing that even if they break several of them, they still come out ahead.

Comment Because they can. (Score 0) 16

They raised prices because they can. The shortage gave them cover.

If Chinese manufacturers can sell an iPad-size Android device with more RAM than an iPad for just $160 retail, this is not about the cost of RAM. Subtract Amazon's 35%, and the total cost of a machine with 40 GB of RAM is no more than $104, and RAM is maybe 5 to 10 percent of that cost, so the wholesale cost of 32 GB of RAM for an iPad is probably no more than $10. And they're cranking up the price by $150. RAM prices did not go up by 1500%.

It is clear to even a casual observer that Apple is just taking advantage of the massively inflated consumer price for the small amount of RAM that isn't being bought up by computer and device manufacturers, and is assuming that users won't be shocked to see their computer prices go up comparably. But those of us who have a clue recognize that the reason for retail price increases is that companies like Apple have multi-year contracts for nearly all the RAM, and the folks selling parts at retail are getting what's left over. I can pretty much guarantee Apple's prices aren't fluctuating nearly as much.

So of that $150, probably about $145 will show up as increased profits.

Guess I'll hold on to my M1 MacBook Pro and my iPhone 15 Pro for a few years longer. I was thinking about upgrading. Now I'm not. And I bought an Android tablet instead of an iPad two weeks ago because the prices were already way too high for what you get. Apple is pricing themselves out of the market, even for folks like me who have used Apple hardware exclusively since the mid-1990s and have high disposable income.

Selling fewer and fewer products at higher and higher prices is exactly why Apple nearly went bankrupt in the 1990s. This is not a winning strategy. They've tried this before.

Comment Re:2352 (Score 1) 93

Look at how many Native Americans died from their first exposure to various European diseases.

Yes, they had genetic disadvantages in dealing with European diseases, having had a low MHC diversity due to the Beringian Bottleneck (particularly HLA genes), combined with no evolutionary pressures from European diseases. Is your belief that children evolve in the process of becoming adults?

Epigenetically, yes, actually. The extent to which this affects immunity is unclear, however.

To be clear, this isn't the only problem that they had. It is also true that many diseases are more severe if first contracted as an adult instead of as a child, Europeans had contracted many of these diseases as children, while the native populations were encountering them at a broad range of ages. But there's a massive difference between "being exposed less often" and "not being exposed at all", as if you're living in a hermetic bubble.

In the context of a thread about the common cold having been eradicated for hundreds of years, that's "not being exposed at all". My assumption is that such a thing would happen through vaccination that eventually results in the case count reaching zero, and after a period of time, the vaccination being phased out, at which point the virus in question would no longer be circulating. If that's not what was meant by the original premise, then that's an entirely different question.

What you change is how frequently people get reinfected.

And if that number is zero...

And it's a myth that you need to keep catching the same disease every time it comes around to maintain immunity. T and B cell immunity against severe outcomes is far more durable than that.

Lifetime reduction in severity for the first kind of flu you are exposed to as a kid. Yes, I'm aware of how this stuff works. And yes, I know about Yamagata. And in a couple of hundred years, if Yamagata suddenly got reintroduced, it would be bad, because nobody would have been exposed to it. That was my point.

Comment Re: Observational study can't claim causality... (Score 1) 233

You also should not kill people who stand where they shouldn't stand. "They were not allowed by traffic rules to be there" will not help you in court.

That likely depends on whether you should reasonably have noticed them in time.

Either way, though, your comment misses the point. If I understand correctly, the taller hoods were correlated with a higher rate of pedestrian injury temporally based on the number of vehicle sales in a given year, rather than directly, based on the type of vehicle causing each reported injury or death.

Assuming that is correct, then it is worth noting that something else also started happening in 2009: smartphone sales skyrocketed. The iPhone got people's attention in 2007, but smartphones didn't start becoming really popular until the price drop in late 2008, combined with the subsequent release of Android devices in late 2008. The LTE rollout in about 2010 to 2012 also pushed prices down, which accelerated the momentum. So unless that correlation was adjusted for, it seems entirely possible that the correlation is spurious, and that distracted pedestrians are the primary culprit, rather than hoods, in which case we could spend huge amounts of time and money making hoods shorter again, and it could make zero difference.

Comment Re:And water (Score 1) 233

Maybe you should prioritize human safety and not cars. Just an idea.

Actually, the GP may have worded it in an appallingly insensitive way, but the answer is correct. There is no safe way for cars and pedestrians to be in the road at the same time. The way you fix pedestrian safety is by:

  • Requiring all traffic light pedestrian cycles to give pedestrians complete control over the entire intersection (all directions), with no turns, for a period of time (a.k.a. pedestrian scramble intersections).
  • Regularly ticketing pedestrians who cross when it isn't their turn.

That's it. If you do this, every single pedestrian death that doesn't involve the car physically leaving the roadway and driving on a sidewalk becomes the pedestrian's fault, because pedestrians can never be in the road when cars are moving, and vice versa.

It is also more efficient for traffic overall on every street that doesn't have a dedicated right turn lane (or left in the U.K.). Instead of pedestrians forcing cars to wait to turn right, which forces the straight traffic to wait behind those cars, reducing the number of cars that get out from dozens to as few as one or two, the cars get their entire traffic cycle to themselves. And because pedestrians are crossing in every direction at once:

  • It likely adds up to only a bit more time than the turn blocking chaos for the cycle in one direction, and far less than their impact on both directions combined.
  • It means that the car cycles can be shorter, rather than having to extend them to allow pedestrians to cross, which means the overall total cycle time doesn't increase much, if any.
  • If pedestrians have to cross both ways, their travel time is reduced (and it is better for cyclists, too, assuming you allow them to carefully use the intersection during this time), albeit with potentially more latency for pedestrians if they are crossing only in one direction.

But it only works if you do it consistently at every intersection in a city and then enforce it consistently by ticketing every pedestrian who crosses against a don't walk sign. Otherwise, you get pedestrians who make a habit of crossing when they shouldn't, and sometimes they get hit by cars. But if you do these things, plus adding some parking garages and eliminating road-side parking, you should be able to cut out about 99% of pedestrian deaths.

Comment Re:2352 (Score 1) 93

That's not how it works. The disease doesn't magically become more lethal because it hasn't been seen in a while. All of those would simply be handled by the primary immune system - the symptoms might be a bit worse at first as the body builds up its immunity, but the common cold is still the common cold no matter how long it has been dormant.

Some diseases do. Look at how many Native Americans died from their first exposure to various European diseases. That said, there are something like 160 strains of rhinovirus, so you're always getting different one each time you get sick, with no prior immunity, as far as I know, so for that specific variety, I'm pretty sure you are correct.

Comment Re:Backfire (Score 1) 93

> Well, if the solution is vaccine-based, no because it *does* train the immune system

In the old days when we were injected with dead versions of actual viruses, yes.

For a robust immune response, you'll generally want an attenuated virus, not a dead one. I mean, it doesn't matter much for something like flu, because it mutates so quickly that any immunity approaches zero after two or three years anyway, but for any vaccine that you want to actually last for decades, unless your exposure risk is low (e.g. polio in the western world), a live, weakened infection is probably a better option.

Today when they're programming our own cells to create parts of real viruses... what exactly are we training it to do?

See above. The reason attenuated viruses are so much more effective is because they trigger multiple levels of immune response by infecting cells. Programming cells to create parts of real viruses differs only from attenuated vaccines mainly in that the resulting products do not then go on to infect more cells, and that the mRNA bits are usually time-bombed so that they stop producing those virus parts after a period of time, thus minimizing the rate of actual cell death.

But either way, the continued exposure over a longer duration, coupled with the involvement of cellular stress signals, help trigger both the innate and adaptive immune systems, resulting in a stronger immune response than if you just had bits of unexpected dead virus material floating around in isolation.

The immune system is incredibly complicated and we're pretty much just injecting people and hoping it doesn't train the immune system to attack their own bodies instead of the virus.

That's actually way more true with the dead virus vaccines you think are so great. For a classic example, the flu vaccine that caused a detectable uptick in narcolepsy (an autoimmune condition) in Europe, called Pandemrix, was an inactivated, adjuvanted vaccine. The adjuvant somehow triggered autoimmunity in some people. And the adjuvant was needed precisely because without that, the inactivated vaccine did not produce an adequate immune response.

IMO, the odds of an mRNA vaccine causing an autoimmune response are likely orders of magnitude less than an adjuvanted, attenuated vaccine doing so, because an adjuvant causes the immune system to pay more attention to whatever is nearby, including your own cells.

Processionals are literally paid to tell you to use their products. Why would you listen to anything they say?

Not all of them. Some of them are independent research scientists, some of them immunologists working in the public sector or academia, etc. The percentage of professionals in this area who work for the vaccine companies is tiny compared with the percentage of independent researchers studying viruses and vaccines. That said, I'd trust even the research teams at the vaccine companies over some random person on YouTube or other Internet sites who shows no actual sign of understanding immunology, but bulls**ts just well enough people to convince a lot of other people who also don't understand it. And sadly, I've seen so much of that level of noise that I have a standing "No, I won't watch your YouTube video about medical subjects; if it were legitimate, it would have been published in a properly peer-reviewed journal" policy at this point. :-)

Comment Re:Backfire (Score 1) 93

On the other hand, having access to clean water may have made us more susceptible to catching the shits when going in third world countries, but I'd take our clean water system and sewers over those of India any day.

I mean sure, the folks without clean water might be less susceptible, but only because they're the ones still left who didn't die from it the first time.

Comment Re: It's not the way that it looks (Score 1) 29

I didn't even realize the newer digital cinema cameras added microphones. But it makes sense even if the quality is terrible for the reason you said.

Every digital cinema camera I've ever heard of has XLR inputs. So if you don't mind being tethered to the boom operator, you don't necessarily even need a field recorder. It all depends on what you're shooting and where and how.

But yeah, decent mics are cheap enough now that even low-end DSLRs have at least survivable mono audio.

Comment Re:Mob-ruled Anarchy (Score 1) 196

canvassing turns any vote into a popularity contest, I don't think that's how it should work

Not necessarily. Canvassing can also bring broader attention to something. For example, I'm hearing about this, and my politics don't align with his, but now I'm curious what the issue is about, and might actually pay attention to it.

Comment Re:Mob-ruled Anarchy (Score 3, Interesting) 196

Dude... really? That's exactly what you were trying to do with your followers before you were caught red-handed.

At some point, it stops being a mob and starts being a vote. And while it makes sense to not allow people to drag random folks onto the platform just to vote your way, it doesn't make sense to limit voting on an important issue to the 0.1% of users who pay close enough attention to notice. So I can see both sides on this one.

Maybe the right thing to do is to require a certain level of activity to earn the right to vote, then dump the canvassing rules. That way, any canvassing would only serve to increase turnout, rather than truly padding the ballot box.

Comment Re: It's not the way that it looks (Score 1) 29

Although the film cameras and audio both have time codes captured now, they aren't a single file. Likely not even captured to the same storage. A lot of intake workflow that can probably be and already is automated in a traditional way, though.

Doesn't even need time code. FCP lines up the files by matching the audio, mostly, IIRC. Also AFAIK, digital cinematography is pretty much the norm at this point, so film likely doesn't factor in most of the time.

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