Comment Re:Nope Nope Nope (Score 1) 183
You're incorrect. You couldn't be more wrong.
In the case of old-style vaccines, the antigen is not attached to any cells. The only thing that the immune system attacks is the antigen.
For mRNA, you want the mRNA to stay local, since the mechanism has your own cells producing antigen, and those *cells* are attacked. Not an issue with muscle cells.
However,if the mRNA enters the bloodstream, it means that actual organ cells may be the target of the immune response, which in turn causes inflammation. The heart? Myocarditis, pericarditis. The ovaries? Sudden erratic periods. The brain? Brain fog.
This is why there were negative side effects. See: https://pmc.ncbi.nlm.nih.gov/a... - tl;dr is easily read in their conclusion:
"A wide distribution of vaccine mRNA in organs can lead to systemic adverse effects and, therefore, there would be a need in the future to develop lipid nanoparticles allowing targeted delivery of mRNA vaccines in specific cells..."
So no, you absolutely don't want a "generalized response" - at least, not from the underlying mRNA mechanism.