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Comment Re:2352 (Score 1) 109

Sigh. Ontogeny is NOT evolution. It is not the same thing as having a low MHC diversity due to a genetic bottleneck as well as lacking tens of thousands of years of evolution to a pathogen. Not the same at all. It's silly to even suggest that. Epigenetic shifts in an individual do not create new HLA genes.

Consider COVID. Novel bat coronavirus, nobody had preexisting immunity. Did everybody die? No. Because we had high HLA/MHC diversity, making it easier to target SARS-COV-2 epitopes. Native Americans lacked this diversity. It left them ill prepared for novel pathogens.

Also, you seem to believe that any disease you've never encountered before is fundamentally dangerous to an adult. That's simply not the case. Rhinovirus is intrinsically mild. It's an upper respiratory infection; it's not adapted to lower respiratory or systemic infection. It's not ebola. It's not going to become like ebola just because you've never caught it before. If a rhinovirus strain was reintroduced after 200 years after having been eradicated, we'd all get a cold, but by and large, we'd be fine.

And what would happen if Yamagata reappeared? We'd just add it back to our flu vaccines. Furthermore, the reintroduction of Yamagata wouldn't be catastrophic without that. You do not have to catch every Influenza B lineage at all, let alone every year. If you had been infected with B/Victoria and you were exposed to B/Yamagata, you'd have little sterilizing immunity against it - you'd very likely catch it. But your past exposure to B/Victoria is still greatly protective against hospitalization and death; B and T immunity against NA and the HA stem and stalk are conserved.

And this is about whether or not to catch every lineage. Well guess what, even with air filtration, that's still going to happen. Air filtration only has a meaningful impact for people at a distance, not people close together. It's about protecting the person across the room, not the person you're standing 50 centimetres away from. What it does change is how often you catch them. And if lineages or whole viruses go extinct, that's great. Worrying about some sort of reintroduction 200 years later is just inventing your own unrealistic misery when we have actual pandemic threats to worry about.

Comment Re:Who's Who? (Score 4, Insightful) 122

Frankly, the quality of build, the stability of the operating system, and just the plain reliability and features even in the supporting tools exceed Windows. Take the Preview App. The work I can do on PDFs; signatures, annotations, OCR, right out of the box, and built so that the versions on my iPhone and iPad fully integrate, cannot be easily replicated on Windows. Apple just really has an eye for workflow, and making sure the base system and tools fit well into that.

It's not perfect, to be sure, I wouldn't want to use Pages as my full time word processor, and Apple, like Microsoft and Google, suffer designed interoperation friction, which does suck. But all in all, I'm just more efficient on a Mac, and in subtle ways I never knew were even problems until I picked a MacBook up the first time. Honestly going to Windows right now is just horrible for me, particular Windows 11, which just feels like constant chaos and out of control busy-ness.

Comment "Wolf!" I've been seeing articles like this (Score 1) 31

since the 1970's Viking missions. Nobody will really know until we get samples back on Earth. (I hope we have immunity if a lab leak.)

The Viking landers detected what look like circadian rhythms, where organisms have an internal clock to optimize metabolism to fit daily temperature swings. The pattern of the rhythm fading over time when kept a constant temperature, and after being baked fit the pattern of certain Earth microbes. But "funny chemistry" can't be ruled out. Mars is a tease.

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