Fundamental principle of any intelligent life form is that it will compete for resources within its ecosystem. It is conceivable that we don't understand something about the nature of our galaxy, but to our best knowledge everything is finite, even in Very Large but Finite universe.
Therefore any "hard to explain" places would have its own ecosystem constrained by finite resources. At this point two possibilities remain - newcomer to already occupied ecosystem (likely), breakthrough into the new territory creating a new niche (unlikely). In the first case existing ecosystem will be leveraged to full extent (converted into computronium) to help establish a foothold in the new niche, in the second case "pulling up the ladder" to protect the new niche, because what would stop the humanity from re-loading from backups to create second round and new competition for recently departed?
In ether case humanity is toasted. There is just no good outcomes in emergence/singularity cases where it is not human or human-based minds that are doing emergence/singularity.
I think humanity's best chance is to create human-like AIs, and have them carry our legacy. Currently, this AI field does not approach things this way. We are not focusing on "what makes our minds human", instead "what makes it more efficient at task X". As such, AIs will be alien beings, nothing like us (and are naturally efficient at fighting and sending spam) and completely devoid of ethics, compassion, creativity and all other aspects that we typically associate with humanity.