Comment Meh. James Lovelock's idea is better. (Score 2) 80
It's a very simple, even lower-tech approach. Unstable molecules are unstable, stable ones aren't. Life isn't capable of producing stable molecules from stable molecules. Something, somewhere down the line, therefore must produce unstable molecules.
If you use spectrometry and find a planet that has two or more highly reactive molecules (especially if they cannot coexist naturally), that planet has complex life. If you have one reactive molecule that breaks down in sunlight but is being refreshed, that planet must have at least simple life. If the planet has highly reactive molecules that don't readily form naturally, you have life that is nominally intelligent.
No requirement for any technology capable of generating a specific signature. No requirement for the absence of metamaterials. No requirement for a telescope big enough to detect the signature against natural variation.
SKA would be capable of detecting an alien civilization using Lovelock's method anywhere inside of 1,000 light years, given the size and sensitivity currently being proposed. How big would the James Webb telescope need to be to get an IR signature on the industrialized part of the US at that range?