If we ever learn to design new genes and proteins quickly, there are a bunch of starter projects:
Give mold the ability to synthesize CBD and THC. It would motivate you to wash your dishes- so you can use a razor blade to scrape off a gooey film of cannabinoids from the slimy ceramic in your sink, puff away, develop the munchies again, refill the sink with dirty dishes, and complete the cycle.
Insert a couple genes into E Coli that can synthesize cannabinoids in your intestines, so you can get a buzz after eating regular brownies.
Give cows a few genes for synthesis of cannabinoids during lactation. THC milk would also go great with regular brownies.
Design a virus that invades the human nervous system and inserts genes into white matter cells to induce synthesis of Adderall.
Engineer mosquitos that have the ability to synthesize heroin.
Make puncturevines that synthesize injectable human vaccines for measles, mumps, pertussis, polio, flu, rubella. and accumulate them in those tack-shaped goathead seeds. Plant them near people who think vaccines cause autism. Also include genes for synthesizing tire sealant, so their needles stop blowing out my bike tires when they reach the curb.
Give chili peppers the ability to synthesize and retain methamphetamine. Pulverize them and you can get meth with that "Chili P signature" like Jesse was selling in the first episode of Breaking Bad.
Create bees that can successfully avoid any areas tainted with anything manufactured by Bayer.
Resurrect DNA from extinct giant bird Palagornis sandersi but modify the legs a little so that the birds can hold bombs and chemical weapons.
Design trees that grow both apples and oranges, so we can finally compare them.