I have Hashimoto's thyroiditis, which is commonly not well understood by general practitioners (to the point of doing exactly the wrong thing for the patient's welfare, because that makes the numbers look good, but leads to immune attacks on not only the thyroid gland, but also sometimes the eyes and other organs). In sheer self-defense, I've had to become an expert, mainly by reading the Journal of Endocrinology.
Removal of the testes is going to affect thyroid production, tho that's something I haven't looked into. If thyroid proves normal, you might ask about slightly increasing your testosterone (females need this too) and/or estrogen intake, or progesterone (which is a mood elevator in some people). Your TG hormone cocktail isn't going to be quite stable if the thyroid isn't right, either.
Low thyroid can affect just about everything. If your depression is at all alleviated by eating, that's a strong redflag, since the food serves to improve blood sugar (albeit temporarily) when thyroid is not doing the job.
https://soylentnews.org/commen...
and that was just what I could recall at that moment; about a dozen more came to mind later, like constipation, chest pain in the region of the heart, mild palsy, loss of coordination, and vertigo.
Also, thyroid production trails off with age... a great many "problems of aging" go away with thyroid replacement, but it is seldom done for that sort of patient. A lot of elderly are suffering needlessly as a result.