I wonder which country's deep space network they're going to use to communicate with the craft

Actual scientific article is at DOI:10.1158/1078-0432.CCR-18-4022.

Phase 1 prospective cohort trial with 15 enrolled patients undergoing primary resective surgery for non-muscle invasive bladder cancer. Primary endpoint is patient safety; they report no "significant toxicities" from therapy.

Secondary endpoint: evidence of tumor inflammation and viral changes. They show inflammation-related changes in treated patients and resolution of tumor in 1 out of 15 patients.

There's no comparison arm; clinically important measures of efficacy like progression-free survival and overall survival were not assessed. The major aim of the study is to justify phase II/III trials down the road.

COI: one of the authors has received funding from Viralytics and several other authors work for Viralytics. Viralytics funded the study.

There is no way a study like this should receive anything like the headline or coverage it's gotten. It is a phase 1 study only without clinically relevant efficacies reported and without a comparison arm. The power to detect uncommon but not even rare adverse effects is low.

...ought not to be defined by the government against which it is wielded.

No, that would be a perilepidopterist!

I am an epileptologist, and I would certainly love to see more effective anti-seizure drugs on the market. But although the newer anticonvulsants aren't necessarily better at stopping seizures than older ones (like the classic four: phenytoin, carbamazepine, phenobarbital, and valproic acid), they are better tolerated, have fewer severe adverse effects, have much more predictable serum concentrations, fewer drug-drug interactions, and require little to no routine bloodwork monitoring. For the 1% of the population suffering from epilepsy who have to take these drugs on a regular basis, this has been a significant change.

Yeah, sure, okay.

It was brave. It took guts. I wish he had just a little more bravery and a little more guts and as much oomph as it took when he held his only-a-little-powerful position. Because now he holds a no-powerful position, vis-a-vis the question at hand. People seeing the light only after they've led horrible organizations do not interest me all that much. Unless it's a prelude to leading a bigger, badder organization to undo the damage.

Add Hawley to the list of people for whom wisdom (or the audacity to voice it) came too late in their careers to make any difference.

I am a neurologist. During training, an MMSE was basically a required component of a history and physical exam of any patient with cognitive complaints. It has its limits, but within them it is very useful.

It's pretty hard to believe that a collection of cognitive tests, almost all of which can be and are used separately in a more customized examination of the patient's sensorium, can be so creative as to be copyrighted.

The idea that the Sweet 16 could infringe because it contains "orienation" and "memory recall" items similar to the MMSE is absurd; questions about orientation and immediate/delayed recall are standard with or without the MMSE.

This is absolutely infuriating from a clinical perspective.

*Nods*. Right. My comment ought not to be construed as a statement along the lines of, "Screw the authors! Gimme!" It's just a goddamn shame that this hasn't been pulled off.

All I want--far, far more than Netflix or Rhapsody--is to be able to give somebody money on a monthly basis to have access to nearly every book in every library in the world. Just somebody make this easy. I don't want to have to think, "Is reading a chapter of this obscure work on Russian formalism worth $0.50?" I just want to fucking click on a link, and read it.

Been an Ubuntu fan for an awfully long time, and evangelized it onto the hard drive of several relatives and work colleagues. I fucking hate Unity. I'm running Natty right now on "Ubuntu Classic" mode to avoid it; and despite all the wonderful things Canonical has brought to desktop Linux, the silliness of this decision has me thinking of moving my main PC to another distro; I've got Fedora 15, Arch, Gentoo, and a few others waiting in the pipeline.