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Comment Related old news: opioids produced by GMO yeast (Score 4, Informative) 39

There has been a proof-of-concept for synthesizing opioids with genetically modified yeast.

we engineered yeast to produce the selected opioid compounds thebaine and hydrocodone starting from sugar. All work was conducted in a laboratory that is permitted and secured for work with controlled substances. We combined enzyme discovery, enzyme engineering, and pathway and strain optimization to realize full opiate biosynthesis in yeast. The resulting opioid biosynthesis strains required expression of 21 (thebaine) and 23 (hydrocodone) enzyme activities from plants, mammals, bacteria, and yeast itself. This is a proof-of-principle, and major hurdles remain before optimization and scale up could be achieved. Open discussions of options for governing this technology are also needed in order to responsibly realize alternative supplies for these medically relevant compounds.

If implemented successfully on a large scale, what are the consequences for traditional opium farmers from already poor regions?

Comment Neil Breen's "Double Down" (2005) (Score 1) 128

Maybe this will cheer you up and lighten the association.

Neil Breen's Double Down (2005) is a film so bad that it's good, or.... at least interesting.

Featured on Redlettermedia's "Best of the Worst":

Full movie:

Comment Copyright infringement =/= Piracy (Score 1) 207

They're actually copyright infringers, not pirates.

Publishers often refer to copying they don't approve of as “piracy.” In this way, they imply that it is ethically equivalent to attacking ships on the high seas, kidnapping and murdering the people on them.

Comment Plea for simplification: static HTML (Score 5, Insightful) 119

It is absurd how much computing power is wasted on dynamically generating what is effectively static content, like blogs.
A simple blog should not require an SQL database and complex software stacks that are executed whenever someone visits the site.

Instead, consider using a static website generator like Pelican, or one of the many alternatives.

Write articles and blog posts in a simple, human-readable markup language such as Markdown or ReStructuredText.
Manage your documents in git. Run the generator to recreate the HTML and update Atom/RSS feeds.
The resulting website is blazing fast and can be hosted on dirt cheap servers.

More simplicity on the Internet please.

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