I assume that, as an exercise, getting 5 simultaneous introductions working makes for a better paper; but is there a reason why you would want that in practice? Especially if there is any wobble in the ratios either randomly, across generations, or in the presence of certain environmental conditions that tweak the plant's metabolism one way or another that sounds like it would be a real pain in the ass to have to re-balance (and, if different patients are deemed to need different combinations even a perfectly stable plant is going to need re-balancing of the outputs) vs. very specifically going for a specific target output per-plant(or e. coli or yeast or whatever is easiest to bioreactor) and then just mixing to taste after purification. Is there some advantage I'm not seeing?

I realize that there are cases where some plant-sourced pharmacological effect looks like it is actually driven not by the identified 'active ingredient'; but by dozens or hundreds of assorted things, and in that case you just have to live with the complexity if you get better results with that than with purified isolates; but if you are deliberately engineering for very specific outputs why a mix of 5?

Immunology, presumably.

The only donor bodies that aren't going to treat the transplant as an act of war are clones or heavily immunosuppressed; and it's probably more plausible to assume that you'll be able to clone a human like a sheep than assume that you'll be making some fundamental breakthroughs in immunology to deal more elegantly with unmatched hosts.

I can see the utility of having spare organs in certain emergencies; but how much life extension would you actually get even if the sort of neurosurgery involved in removing a brain and reattaching it to a new host's spinal cord were viable? Is the theory that the assorted ghastly flavors of neurodegeneration are actually to be blamed on older organs and everything will be fine; or is this just a very expensive way to ensure that you skip the various ways peripheral organs can kill you and are assured to be the spryest patient in the dementia ward?

In short, Java was invented for a reason, and while it has become a victim of legacy cruft as well, the underlying concept of truly portable apps, with a minimum of fuss to jump from platform to platform, still ought to be the preferable path. The problem is that that true platform neutrality/ambiguity pretty much kills Microsoft in all but a few niches, like gaming, but only because hardware vendors put less effort into drivers for other operating systems.

Yes, Office is still king, although I think that crown is beginning to slip, and it may end up being Excel, with its large list of features, that may last the longest. But it isn't 1990, or even 2000 anymore. Developers have multiple ways of developing portable applications, and while MS may (for the nth time) update or swap out its toolchains, the real question is will developers really care?

While it is an enormous problem, possibly the most significant, we know how to shield against radiation, but it's going to take mass in the form of hydrogen-rich molecules like water or polyethylene (as examples). To solve that problem we are either going to have to make launches a lot cheaper, or figure out how to do it all in orbit.

It's at the edge of our technological capacity to produce such a spacecraft now, so the barrier is economic. That's a massive barrier, but in theory we definitely could, if we put a significant percentage of GDP of the wealthiest nations towards the project, produce a spacecraft that keep astronauts alive and relatively protected from ionizing radiation both on the journey and while on Mars.

As to your general assholery, I guess everyone has to have an outlet, though why Slashdot is a bit mysterious.

Mostly just in the bulk, low barriers to entry, and pervasiveness(like a lot of things social media). The case of actors actually goes back a long way; state laws regarding compensation of child actors were spurred by the case of one who was popular in the 1920s and litigated with his parents over where the money wasn't in 1939. That case doesn't provide for takedowns; but it's also the case that filmmakers are normally looking for children to play characters; rather than to do 'candid' intense documentaries of them at home; so the degree of public exposure of private life is presumably deemed to be less; with the main issue being children who were...definitely...getting a solid education while on stage finding that all the money was gone when it became their problem.

Child-blogging, by contrast, seems to reward verisimilitude (if not necessarily truth) and invasiveness, relatively pervasive in-home mining for 'content', so presumably seems better served by removal-focused options; though there has definitely been talk about covering the economic angle in line with child actors.

I don't even know what the deal is with child beauty pageants, or how something you'd assume is a salacious bit of slander about what pedophile cabals are totally doing, somewhere, is actually a thing a slice of parents are into, way, way, into. Apparently that's a third rail to someone, though, as the only jurisdiction I'm aware of with significant restrictions on them is France.

Unless quantum computing becomes cheap and comparatively widely available quite quickly after becoming viable passwords seem like they'll be a manageable problem. Nobody likes rotating them; but it's merely tedious to do and the passwords themselves are of zero interest unless they are still being accepted. If it does go from 'not possible' to 'so cheap we can just go through through in bulk' overnight that could ruin some people's days; but if there's any interval of 'nope, the fancy physics machine in the dilution refrigerator is currently booked by someone with a nation state intelligence budget' you can just rotate older credentials.

Now, if you were hoping that encryption was going to save any secrets that are interesting in and of themselves that got out in encrypted form; then you have a problem. Those can't be readily changed and will just be waiting.

Plus the whole 'fucking dystopian' angle. On the one hand we've got people bitching about 'civilizational decline'; but we want 'robot philosophers' teaching children? I'm not against the occasional scantronned multiple choice test; but outsourcing philosophy to save on those oh-so-expensive adjuncts seems like the sort of thing you only do to children being groomed for mindless servitude or because you've entirely given up on humanity as anything but an ingredient in pump and dump schemes.

One of the lessons we've had as the Federal, multi-branch nature of the US governmennt has frustrated Trump is that the government may be fucking us over, but it's not doing it in *unison*. It's doing it piecemiel, on the initiative of many interests working against each other, just as the framers intended. The motto on the Great Seal notwithstanding, there are myriad roadblocks to consolidating power in the hands of a single individual. It takes time and repeated failures. This is why the second Trump Adminsitration is worse than the first; they've figured out ways around things like Congressional power of the purse, put more of their henchmen in the judiciary, and normalized Congress lying down and letting the president walk all over them. It's a serious situation, although fortunately Trump isn't long for this world.

This debate has been going on for at least a couple of decades. I remember back in the Usenet days, when AOL and other early ISP users first started showing up in droves with whacked out untraceable bang paths that people were trying to sort out technical solutions, usually involving some servers tarpitting some domains, with the inevitable consequence that valid users (by whatever definition any given Usenet group had) were blocked.

In a way, AI bots aren't any different than the spam problem on fax machines and email; universal low-barrier delivery meets large scale programmatic swill. AI allows complexity that earlier spambots couldn't dream of, when the most sophisticated way of defeating filters was spelling "porn" as "pr0n" and a bit of header fuckery. In the end there is only two ways to go; either do what filtering you can and accept some degree of false positives, or go to identification systems that will, one way or the other, compromise anonymity, because make no mistake, once you start storing any kind of data linking an account to an actual human being; biometric, picture ID, phone number, mailing address or whatever, it won't take long for the court order to show up demanding you hand over all the de-anonymized account data to find the person distributing child porn, drugs, or calling their local political representative dirty names.

I'd be more optimistic about the ability to deliver an approximate equivalent if there were someone paying for them to do so(the economics of ordinary satellite launches seem to favor fitting within what a given delivery vehicle can handle, rather than bolting things together, so it's not 100% assured; but seems likely); but less clear on replicating the incentive structure.

It's not that the ISS is totally useless; but it currently justifies an awful lot of launches, including manned, more or less by being there. Gotta launch that crew lest the ISS be empty which would be bad because reasons, and have to launch those supplies because there's a crew on the ISS. They do find scientific things to shove into modules; but the arrangement is such that no project is ever called on to justify the ISS, which is just sort of assumed.

Short of the feds just paying some contractors and calling it a 'private' ISS replacement; it's less clear that there's much private sector incentive to build an ISS-like; judging by quite vigorous stream of privately justified satellites designed to not be bolted together and the relative absence of jostling for ISS experiment space. If it were worth that much we'd presumably be up to our eyes in sordid stories of people pulling lobbying stunts to try to exploit it on the cheap through regulatory capture; but we aren't really.

Neo and Android-based Chromebooks, and "good-enough" Office alternatives like Google Docs and I would argue even LibreOffice (I use it almost exclusively these days), mean Microsoft is suffering a differentiation crisis. They'll likely have the corporate lock for some time to come, though they've managed to fuck up Outlook so badly that I have to be wondering if the only thing really keeping the big guys locked in as Teams at this point.

MS's ability to leverage Windows as the platform is decaying, and the "bells and whistles" approach has managed to alienate a lot of users. People are at the point where they use Windows because they have to, but there's enough platform-agnostic functionality out there that the old lock-ins they relied on to keep Windows dominant are becoming more like prisons for their own development teams.

I know MacOS has its critics, and in its own way it has its UI lock in, but after using it now for four years, and my use of Windows now being reduced to an RDP session at work, I have to say the experience overall has been pretty pleasant and productive. The lack of update nagging, the sheer horsepower of Apple Silicon, an actual *nix prompt instead of WSL, printing that isn't an absolute shitshow (and this is saying something because Windows used to be the reigning heavyweight champion of plug and play printer handling).

Windows 11 is its own type of hell, and every time I'm forced to use it I find it a slow, bloated, unintuitive mess. It feels like Windows 7 if you had let your 12 year old kid download a whole bunch of dubious software and now the desktop and taskbar do strange things while spam spontaneously appears. If someone had shown me Windows 11 fifteen years ago I would have gone "Holy shit man, your Windows 7 machine has been rootkitted!"

And here I thought that 'AI' was supposed to be leading to a flowering of specialized-for-purpose software that would previously have been infeasible to build due to resource constraints; but one of the most heavily capitalized outfits in the bubble can't cope with a chromium reskin and a couple of electron apps?

While that's true, a responsible generation aims to boost the next generation to a *higher* level than the education they received. The world has become more complex and faster-paced, and even if that weren't true, the consequenes of aiming high and falling short are better than the consequences of aiming for the status quo and falling short.

So while I'm 100% onboard with skepticism that technology will magically make education better, I think the argument that "the education I got worked for me should be good for them" isn't a strong argument. What we need is a better ecducation that would have been a better education fifty years ago: stronger math, science, and language skills, general knowledge, and, I think critical thinking and media literacy. Possibly emotional intelligence -- it's kind of pointless to teach people critcial thinking skills if they are carried away by emotions.