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Comment What is the performance? (Score 2) 47

In a Claude Science demo, Oliver Vince, PhD, co-founder at Basecamp, uploaded a sample patient microbiology report. When given a simple natural language prompt, the platform designed peptides, predicted their efficacy, and provided a shortlist of candidates most likely to succeed in experiments in minutes.

This is a meaningless statement. I too can create a tool to generate a list of peptide candidates with minimal effort. It may even be somewhat useful if it based peptide sequences on homology searches or some other relevant biology instead of random string generation. This has been an active area of research for than 20 years. In order for this to be newsworthy. Claude has to be better than what already exists. How many novel candidates does it generate that actually have useful antibiotic properties? Do I have to screen through a list of 100 candidates to find one that actually works? If so, that’s not much better than a BLAST search and it costs a lot more. What is the strain selectivity of the new antibiotic? Is it broad or narrow spectrum? How easy is it to manufacture? Are there any toxic side effects?

Assuming a new antibiotic is actually what’s needed, instead of using one of the many beta-lactams or combination therapies that already exist, generating the candidate is the first and easiest step of a long and expensive process to developing a novel drug.

Comment Re:Read the Legislative Analysis (Score 1) 19

The committee analysis greatly exaggerates the requirements, but the objections are still at least somewhat valid. If a company (imagine a developer-owner, one-man show) stops hosting the only live server for a game because he's taking care of an ill spouse, why should he be obligated to make significant software modifications, host those patches, or create documentation instructing how to create and host a the game via a private server. And if he doesn't do so, then he has to refund everyone at the HIGHEST PRICE for which the game has sold in the last 12 months?

It should be fairly easy to carve out provisions for exceptional circumstances (ex: bankruptcy proceedings), and is probably common practice already. But I agree the language has an implied target which is not good for getting legislation passed, generally. It should be possible to propose reasonable accommodation for majority circumstances without sounding like a manifesto.

A BETTER bill would have been simple: "The IP-holder of a video game that ceases distribution/hosting ALSO relinquishes both liability and control over software replication and hosting."

That will run into problems with federal copyright laws and other IP protections. While it sounds just, it is unlikely to get anywhere. More likely is large companies would have to have an end-of-life plan for their product (which they likely do already) that includes considerations for how to keep the game playable after servers are taken offline. It could be as simple as releasing the protocol to enable third parties to host servers. Or, better, designing the game for offline play from the beginning so that the final patch set is just a simple switch.

Regardless of the outcome, however, this really does seem like a pre-eminent example of “first world problems”.

Comment Re:"Just" 59K (Score 1) 98

Central banks do a lot of useful things, but they don't give currency a value (they can, however manipulate the value others give it by printing it, destroying it, changing interest rates, changing the amount of reserve banks need and the multiple they can lend, etc). What gives a currency value is supply and demand- the fact other people want that currency. Which is also what sets international exchange rates.

There's also the fact you need it to pay taxes, which sets a base amount of demand. But beyond that it's all supply and demand when deciding how much value it has against other currencies or physical objects.

Comment Well, it's been nearly 20 years ... (Score 1) 23

How is this different from the Sun Modular Datacenter from 2007? Dell was talking about building an entire data center, which was just a "central spine" with a bunch of similar containers attached. Dunno how many of those were ever built but the containers full of computer hardware were, most definitely, built.

Oh, it's got a bunch of GPGPUs in it, not just standard rackmount servers. Well, it's been nearly 2 decades, so I guess they're hoping the people at the patent office don't remember that.

Comment Re:C (and here are somemore chars to satisfy the b (Score 4, Informative) 40

Why would you do that? If you're using it for non-strings, you'd never have used strncpy, you'd have used memcpy. Which is the same thing without the null termination rules of strncpy. You'd never use the str versions unless actually working on strings.

Comment Re:Everyone knows Meta = Facebook (Score 1) 65

> Meta doesn't really know how to do anything else with any skill.

They don't know how to do Facebook very well either: it's been pretty much stagnant and enshittified to death for the past 22 years, and it feels like a forum for greying people whose greying friends haven't bothered to move on either, or to get the date of the next annual meeting of the bridge club.

Comment Oh yeah, Shutterstock... (Score 1) 19

one of those companies whose sole purpose seems to be annoying you by slapping their name as a watermark on a generic image you'd like to use in a meme, and force to spend 10 seconds finding somewhere else because you were never going to pay a stupid company to remove their mark on a bad picture you can find everywhere.

I wonder how those companies still exist, let alone make any money.

Anyway, the modern way to use copyrighted photos for free is to ask stable diffusion to regenerate it, because the AI companies have done all the data stealing for you and repackaged the stolen data into "models" you can use for free.

Comment Re:Hype (Score 1) 27

Well, it says in the abstract (and they have further detailed calculations in the paper) that they achieved an average desalination rate of 1.76 kg/m^2/h. So that’s about 1 gallon of water in one hour with 2 m^2 panel. That said, they did their tests using a 9 cm^2 panel, so yields may change significantly on scale up. Not sure if that translates into meaningful cost savings at scale, but it does seem like a significant advance in solar desalination technology. It seems like the paper was focused mostly on salt harvesting, though, rather than desalination. So I expect the real utility to be the combination of the two rather than desalination by itself, if it scales.

Comment Re:It's gonna be fun (Score 1) 44

Of course if those aren't securities, then the entire site is illegal as it's operating as a securities exchange. That's their legal argument for why they aren't gambling sites, and shouldn't be regulated by state gaming commissions. So expect the full might of all those prediction market sites to be lining up against that argument and for finding him guilty.

Comment Re:Scalper incentive (Score 1) 41

Scalping isn't, and shouldn't be, illegal. You own the ticket, you should be able to do what you want with it, including reselling it.

And no, getting rid of scalpers wouldn't make ticket prices higher. Scalpers exist because the concert ticket prices are lower than what the market will actually bear. If a theater full of people are willing to pay 1K for a concert and they sell the ticket for 500, a scalper can make a profit via arbitrage. The only actual way to get rid of scalpers is to raise the prices to the sky (like 2-5x current prices) and slowly bring down prices over time until they're all sold. But my guess is you probably wouldn't like that any better, as the end price would likely be higher than the current scalpers price.

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