Yeah, but 400 years is a bit longer. They'd need a different reactor design. Perhaps one that works on waste from the current reactors, but they might need to take along (or build en-route) mechanisms to refine the waste again as it kept decaying.
(N.B.: I didn't even THINK about doing the math, but reactors that require high level radioactive fuel won't keep running long enough, but one's that use less active fuels could. Of course, they'd be a lot larger. If you're going to use an RTG, and you want it designed for this purpose, I think you'd want to design it for a fuel that had a half life of 800 years. So it would need to be a lot bigger for the same amount of power.)