I've spent dozens of hours trying to actually complete this game on the XBox 360, and it's impossible. Given Bethesda's track record, do NOT buy this for consoles - they will not patch these problems. Fortunately there's an active modding community on the PC, and there's a mechanism in-game (again on the PC only) for adjusting broken objects, characters, stories and plotlines on the fly. On the console, you're just screwed:

* Game will eventually corrupt your save game with no chance of recovery.
* Game will eventually start freezing when buying from merchants (especially if you purchase a Caravan playing card)
* Game will crash if certain story choices are made, or will not be completable if certain story choices are made
* Game will crash if certain gameplay choices are made (e.g. don't shoot Caleb McCafferty in the head)
* Game will randomly crash when fast traveling (anywhere, any time. I'd suggest saving often but you'll run a greater risk of save game corruption)
* Game will randomly cause areas of the map to be "dead zones" - entering them triggers a crash (e.g. Nipton)

Bethesda has only acknowledged one of these problems, and it's taken them more than 2 weeks to promise a fix (which they haven't yet). This article is spot-on - don't buy buggy software. Bethesda makes buggy software. Don't buy Bethesda software Q.E.D.