Given where the timezones are, certainly not 'most' people. Yes, you can cross a time zone in less than 25 miles if you happen to live within 25 miles, this doesn't support your stance of "most americans spend at least a day timezone shifted every year", since that's a pretty specific circumstance that doesn't apply to most people.
Even for them, I wonder what percentage of those trips introduce inconsistency in their schedule. If they work in one timezone, then they would consistently be living according to that schedule, even if they technically sleep in another.
Personally, if I am stuck with a trip that goes more than a time zone over, I just hate the shift.
Shifting the time is a PITA that is pretty jarring in a way most people don't enjoy and it seems like it may be outright unhealthy.