While they're currently only applying this to people with extreme cholesterol problems, there's no reason the same treatment wouldn't work for anyone on statins. They use different dosages to impact a different percentage of the liver cells to adjust cholesterol levels, essentially introducing a mutation found in a small percentage of the population where a particular gene is inactive. For people with more manageable cholesterol levels, they would presumably just need a lower dosage to get levels below that where medication is required.

So for now, this will likely be only used in extreme cases, but over time, this could be an alternative to statins just like lasik is an alternative to glasses.

I would love to stop taking my statins, and I'm sure many other people would also opt for something like this. Once they get more experience in the more extreme cases, there's every reason to believe they'll open it up for wider usage. Apparently between 50% and 65% of people fail to take their statins consistently for various reasons, so this could be much more effective and reducing heart disease.

They're effectively introducing a rare genetic mutation. They found some people who have extremely low cholesterol, and it's due to one broken gene, so they introduce that change in some percentage of the liver cells to reduce the cholesterol levels. They can do studies of people who already have the mutation naturally to get an idea of any expected health impacts.

I think the Rivian approach is the best. They're basically copying the Tesla model of having their fleet send the sensor recordings back and then using them as training data. While they're far behind right now, they'll catch up quickly, as they can copy a lot of the basic technology that's now established instead of having to invent everything from scratch and make wrong decisions along the way. The difference is Rivian is including lidar, so they just include the matched video and lidar recordings as a larger training data set. I'm convinced that if the price of lidar was more like it is today back when Tesla started selling FSD in 2016, then that's exactly what Tesla would have done, but Tesla is now stuck with their solution with ten million cars already on the road.

But in clear weather conditions, I don't think lidar really helps that much. Most human accidents would be avoided if drivers had better situational awareness and didn't have gaps in paying attention, and the cameras solve that.

I don't know what expectations these are defying unless they're from those created by anti-EV FUD. I thought it was pretty clear that EV batteries usually last longer than the cars themselves. If 250K is exceeding expectations, then the expectations are wrong and haven't been supported by the data for a long time.

Yeah, that's not really a thing in LEO where debris clears itself fairly quickly due to atmospheric drag.

This is about reducing ewaste, so how about phasing it in by requiring increasingly long warranty periods for non-replaceable batteries?

I love that I can self-host Bitwarden, and I do it with Vaultwarden, which is open source, so I have no fear of it going away. But if the company got really obnoxious and blocked self-hosted servers from the browser plugins, then I would be in big trouble. I don't think the changes listed suggest that they're going to do that anytime soon, but it's something I want to keep an eye out for.

How exactly do they ban updates? If they publish an update for Canadian owners, nothing stops Americans from installing it.

We should rewrite SystemD in D and call it DsystemD.

(Yes, I program in D, but I avoid SystemD, thanks to Gentoo Linux letting me stick with OpenRC.)

I'm used to Dungeon Masters being cryptic, and my party often ends up in crypts, but I've never had the DM encrypted. Sounds like a nasty curse.

I have Powerwalls, and also happen to live in Massachusetts. I participate in the virtual power plant program, where the batteries dump to the grid for an hour or two during peak demand in the summer (typically 5-7pm on hot days). I get paid nearly $1000/year for each Powerwall. Car batteries are much larger. I would love to be able to have my EVs participate in this, as well, but our cars don't support bidirectional charging. If they did, we would love to be part of this, assuming the terms are similar.

How does this compare with Samsung DEX that has been on Android for years to provide a desktop experience? I played with it a bit when work started requiring us to be in-office but without assigned cubes and static equipment, as I could, at least in theory, do everything I needed with a keyboard, mouse, screen and my phone driving it all with a VNC app to do my real work on a Linux server.

I rather liked it, but it had some glitches where it wouldn't always recognize the monitor from the docking station, and it couldn't make use of a second monitor.

With so many workers now in this situation, and phones having so much processing power, this seems like an obvious solution.

When Lucas sold Star Wars for $4B, it sounded like a ridiculously low number. Even without the rights to make new content, that was worth well over $1B. If he were shopping around instead of giving it to Disney, it probably was worth closer to $10B. With honest accounting, that's probably in the range of value Disney has received, and that's with having produced the worst possible sequels.

Dell has made lots of acquisitions over the years, and each one had their own systems. Dell acquired me at one point (I'm sure that was their intent, and they just got EMC thrown in with the deal), so I've certainly seen this. It took a long time to really merge the companies, and I'm sure they still have many separate systems. Eventually it makes sense to move everything to the same enterprise management system; at least everything that they aren't keeping separate for an easy future spinoff.

While the obvious answer is to move everything to Dell's existing system, or possibly EMC's, they may well have realized that none of the existing systems were adequate, so it was time for a new one. Might as well rip the bandaid off quickly all at once and be done with it.

Catalyst was the project name.

Or was Catalyst the replacement for the one that failed?

As I recall, the failed one customized everything for how EMC did things. The replacement changed how EMC did things to match the default, as it was easier to change the company than customizes the software. The only pain point I remember on the engineering side was all the part numbers changing to match the new standardized format.