If you read much science fiction you will have seen a lot of stories about interstellar flight like this. And there are all kinds of solutions, many of which involve hibernation or cold storage of the crew while some kind of AI handles the navigation and ship systems. Usually it goes haywire in order to generate drama.
Sometimes there's a rotating set of human skeleton crew that gets awoken to make sure things are going okay. In the novels there will be all kinds of tension associated with that, or the ship gets damaged somehow, or aliens catch up to it and wreak some havoc. In other iterations the crew consists of frozen embryos that get birthed at some point, raised and educated by the AI, and reach adulthood in time to witness the orbiting dead rocks and gas giants they came so far to see.
The most realistic scenario is a small completely robotic craft without all that life support cargo similar to what we are already doing.