Comment Read all the details (Score 2, Informative) 42
Comment Re:Personal accountability.... (Score 2) 74
Right! That's exactly it. I was part of "Gen X" myself, and while I had friends who lived the whole "latchkey kid" lifestyle to the max? It really wasn't the norm to just be unsupervised all day or night.
I remember my folks both worked, but my mom went to working only part-time, early in the morning until around the lunch hour, when we were younger. She hired an older lady as a part-time nanny for us while she was gone. When we got older, mom was always home by the time school let out - so we barely knew she was ever gone.
And also true that even for the teens I knew who had a house to themselves after school each day until bedtime? Their parent(s) weren't just buying them electric motorcycles or any of that like you see going on today. Obviously, the Internet wasn't anything like it is today. Even as a hard-core computer geek though? I called and ran my own computer bulletin board system where it was just really a local niche community of like-minded people dialing in with modems. Most heated arguments that came up on a BBS got squashed when the BBS operator decided he had enough and banned all of them. It just wasn't *anything* like what goes on now where people get video-recorded against their will in high resolution just so someone can get famous on TikTok, or ?
Comment Citation needed? (Score 3, Insightful) 105
Rei: Do you actually work for Amazon in a capacity where you're informed on how they're obtaining these books?
I'm asking for a couple reasons.
1. We all know Amazon has plenty of money to be able to afford to buy rare, out-of-print books that are difficult to obtain. I'd be surprised if they refrained from doing so if that meant their AI risked not having some of that knowledge/information while a competitor's did. I'm not saying the guy tasked with being manager over the disposable labor doing the book scanning is authorized to make direct choices about what books to buy. I'm saying someone in Amazon corporate, in charge of the AI project itself, was probably given the funding to buy what he/she felt was needed.
2. The original article's anonymous interview with the low-level worker sounded very accurate with such statements as the details/orders changing daily and everything feeling disorganized. I can speak with some authority that that's exactly how it feels when you work for them in a non-management capacity. Multiple layers of management are dictating new processes or policies in a constant stream, and then often? The entire thing is up-ended when top level management makes a company-wide decree or mandate. Your team lead/manager is even liable to change on short notice. Their push to constantly "reinvent" causes a whole lot of reinventing of the same wheel another department or team already invented, and it's kind of a zoo. That's why I'd also take their comments as legit when they express concerns some of the books appeared to be obscure titles, etc.
Comment Personal accountability.... (Score 2) 74
I have to agree. I'm not defending Facebooks' practices, but at the same time? It seems to me social media as a whole can become addictive, or promote bad ideas to kids or teens. You have to control this at the parental level
So sure... slap them with large fines and use the money for good, where you can. I'm not opposed. But your kid or teen wouldn't be spending all day on social media if you controlled it as their parent. By the time they're old enough to legally move out of your house? Then it's too late for you to try to "fix" anything they're doing. But before that, they live under your roof and by your rules.
Comment Re:Just like in Texas (Score 1) 165
Comment Re:Why only brains though? (Score 4, Interesting) 38
Finally, recalcitrant peptides are depleted in cytoplasmic and mitochondrial domains and strongly enrichedby up to 16-foldin calcium-dependent phospholipid-binding C2 domains. C2 domains mediate Ca2+-regulated binding of proteins to anionic phospholipids on membrane surfaces, (58) and their enrichment indicates that peptide persistence is disproportionately associated with proteins stabilized at membranes, rather than within freely soluble intracellular compartments. Loss of ionic homeostasis and rising intracellular Ca2+ during post-mortem decay (6) would be expected to further promote sustained membrane association of such proteins. Membrane-adjacent microenvironments are structurally constrained, concentrating redox-active substrates and catalysts (such as lipids and metals) while restricting diffusion and oxygen availability relative to the cytosol. In this context, radical oxidation is less likely to proceed via chain propagation, which requires continuous access to molecular oxygen, (59) and more likely to locally terminate via cross-linking. Such cross-linking would be expected to reduce molecular mobility and solubility, sterically hinder enzymatic and hydrolytic attack, and promote the formation of insoluble aggregates resistant to degradation. (60)
A further factor likely reinforcing this taphonomic trajectory is the brain’s unusually large and heterogeneous reservoir of redox-active iron. (61) Nervous tissue contains high iron concentrations relative to most other soft tissues, distributed across multiple pools such as heme proteins, ferritin-bound stores, and iron-rich compartments associated with mitochondria, myelin, and oligodendrocytes. (62) In life, these pools are tightly regulated to support oxidative metabolism while limiting collateral damage. (63) After death, however, progressive membrane failure and loss of regulatory control are expected to alter iron speciation and availability, increasing the likelihood of local metal-catalyzed radical generation. Importantly, such chemistry need not produce uniform oxidative destruction: when redox reactions involving iron occur within membrane-adjacent or diffusion-limited microenvironments, they may favor the formation of short-lived aromatic radicals that terminate by covalent cross-linking rather than by chain-propagating oxidation (Table S22). The enrichment of peroxidaseswhich often involve heme iron or metal cofactors (64)among recalcitrant peptides is compatible with localized, metal-associated redox chemistry, in which iron-containing cofactors may contribute to peroxide-driven radical formation without sustaining chain-propagating oxidation.
The brain is particularly predisposed to follow this trajectory. In life, it is among the most oxidatively stressed organs: it consumes a disproportionate share of oxygen, is rich in redox-active metals, and relies heavily on antioxidant and repair systems to maintain protein integrity. (65) Additionally, the brain combines extreme membrane density, (66) an abundance of structurally stable, long-lived proteins that accumulate heterogeneous oxidative modifications during life, (67) and anatomical sequestration within the cranial vault. Together, these features establish a post-mortem environment characterized by pre-existing chemical and structural heterogeneity, limited molecular mobility, and restricted oxygen exchange: conditions that favor local, diffusion-limited radical reactions and termination by cross-linking rather than runaway, chain-propagating oxidation. Notably, the molecular features that define this post-mortem pathway closely parallel those that stabilize aggregation-prone protein assemblies in neurodegenerative disease: enrichment of -sheet and structurally ordered fragments, (68) redox-active residue modifications, (69) and oxidative cross-links (70) are hallmarks of pathological protein aggregation in vivo. While the biological contexts differ fundamentally, these parallels indicate that common chemical processes govern protein persistence across clinical and geological time scales.
Comment Re:I'm not convinced QCs will ever work (Score 1) 45
I know that 28 was wrong.
Great. Progress. Now here's the important thing: If you understood Shor's algorithm you would know that 28 couldn't possibly have been the number. So this should cause you to conclude that you are in general overconfident about how much you know or understand about how quantum computers would function. This doesn't mean you are necessarily wrong, but it should indicate that you are overconfident here or could you use a more detailed introduction or refresher on the topic. My preferred recommendation is Aaronson's "Quantum Computing Since Democritus." The book assumes no technical prereqs beyond basic calculus and a tiny amount of linear algebra.
However, you seem to be totally ignorant with regards to algorithmic complexity. That means you do not even have the very basics needed to be in this exchange.
If you think there's some specific indication that I'm in general ignorant about algorithmic complexity, please feel free to point it out. If there's a specific statement I've made that indicates that, by all means show it.
Comment Re: Is Scott Aaronson eating humble pie yet? (Score 1) 45
Comment Re:Pause non-essential purchases (Score 1) 49
Really, a lot of us in I.T. should have seen this coming.
Earlier in the year, my significant other was still gaming on an Alienware laptop that was about 3 generations behind on its nVidia GPU and had issues like a non-working trackpad (someone messed up the ribbon cable inside it while replacing dying cooling fans in it). We found a high-spec upgrade for it at the local Micro Center, selling for around $3500 with an RTX5090 in it, 64GB RAM, etc. Just about all of our friends advised us not to dump that kind of money on a gaming laptop. "Just wait, they said.... You can surely find something cheaper than that." I told her to ignore all of them and to pull the trigger on it if it's really one she liked.
Only a month later? That same machine was up over $5500. There's basically nothing on the market today with the same GPU in it selling for less than $1000 or so more than we paid for that system. And typically, they only have a 1TB SSD vs the 2TB in hers.
None of us have a crystal ball, but I saw this trend started with price increases on RAM and storage with the rise of AI and new data center construction -- and knew PCs weren't going to go down in price for quite some time...
Comment Re: Robot battle reenactment (Score 1) 64
If you were worried about being chased by kill bots, go and watch some videos from drone operators in Ukraine. Robots don't need feet for that job.