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Comment Re:Simple? (Score 1) 26

For ALL we actually know, Einstein could still be waiting to be proven wrong in many ways.

Einstein died in 1955, so I think we do know for a fact that he's not waiting for anything anymore. But I get what you mean. To wit:

Perhaps the simplest answer is to not assume any human is infallible. No matter how smart. Will we be shocked to find Einstein was perhaps wrong at some point, or will we simply understand and accept he was human.

I for one won't be shocked to find out Einstein is (well, was) wrong. He was many times during his career. So have many other luminaries in science.

Comment Re:And media selection of alarmist data (Score 2) 36

A bit more about the latter. Beyond organophosphates, the main other alternative is pyrethroids. These are highly toxic to aquatic life, and they're contact poisons to pollinators just landing on the surface (some anti-insect clothing is soaked in pyrethrin for its effect). Also, neonicotinoids are often applied as seed coatings (which are taken up and spread through the plant), which primarily just affect the plant itself. Alternatives are commonly foliar sprays. This means drift to non-target impacts as well, such as in your shelterbelts, private gardens, neighbors' homes, etc. You also have to use far higher total pesticide quantities with foliar sprays instead of systematics, which not only drift, but also wash off, etc. Neonicotinoids can impact floral visitors, with adverse sublethal impacts but e.g. large pyrethroid sprayings can cause massive immediate fatal knockdown events of whole populations of pollinators.

Regrettable substitution is a real thing. We need to factor it in better. And that applies to nanoplastics as well.

Comment Re:And media selection of alarmist data (Score 4, Interesting) 36

So, when we say microplastics, we really mainly mean nanoplastics - the stuff made from, say, drinking hot liquids from low-melting-point plastic containers. And yeah, they very much look like a problem. The strongest evidence is for cardiovascular disease. The 2024 NEJM study for example found that for patients with above-threshold levels of nanoplastics in cartoid artery plaque were 4,5x more likely to suffer from a heart attack. Neurologically, they cross the brain-blood barrier (and quite quickly). A 2023 study found that they cause alpha-synuclein to misfold and clump together, a halmark of Parkinsons and various kinds of dementia. broadly, they're associated with oxidative stress, neuroinflammation, protein aggregation, and neurotransmitter alterations. Oxidative stress is due to cells struggling to break down nanoplastics in them. They're also associated with immunotoxicity, inflammatory bowel disease, and reproductive dysfunction, including elevating inflammatory markers, impairing sperm quality, and modulating the tumor microenvironment. With respect to reproduction, they're also associated with epigenetic dysregulation, which can lead to heritable changes.

And here's one of the things that get me - and let me briefly switch to a different topic before looping back. All over, there's a rush to ban polycarbonate due to concerns over a degradation product (bisphenol-A), because it's (very weakly) estrogenic. But typical effective estrogenic activity from typical levels of bisphenol-A are orders of magnitude lower than that of phytoestrogens in food and supplements; bisphenol-A is just too rare to exert much impact. Phytoestrogens have way better PR than bisphenol-A, and people spend money buying products specifically to consume more of them. Some arguments against bisphenol-A focus on what type of estrogenic activity it can promote (more proliferative activity), but that falls apart given that different phytoestrogens span the whole gamut of types of activation. Earlier research arguing for an association with estrogen-linked cancer seems to have fallen apart in more recent studies. It does seem associated with PCOS, but it's hard to describe it as a causal association, because PCOS is associated with all sorts of things, including diet (which could change the exposure rate vs. non-PCOS populations) and significant hormonal changes (which could change the clearance rate of bisphenol-A vs. non-PCOS populations). In short, bisphenol-A from polycarbonate is not without concern, but the concern level seems like it should be much lower than with nanoplastics.

Why bring this up? Because polycarbonate is a low-nanoplastic-emitting material. It is a quite resilient, heat tolerant plastic, and thus - being much further from its glass transition temperature - is not particularly prone to shedding nanoplastics. By contrast, its replacements - polyethylene, polypropylene, polyethylene terephthate, etc - are highly associated with nanoplastic release, particularly with hot liquids. So by banning polycarbonate, we increase our exposure to nanoplastics, which are much better associated with actual harms. And unlike bisphenol-A, which is rapidly eliminated from the body, nanoplastics persist. You can't get rid of them. If some big harm is discovered with bisphenol-A that suddenly makes the risk picture seem much bigger than with nanoplastics, we can then just stop using it, and any further harm is gone. But we can't do that with nanoplastics.

People seriously need to think more about substitution risks when banning products. The EU in particular is bad about not considering it. Like, banning neonicotinoids and causing their replacement by organophosphates, etc isn't exactly some giant win. Whether it's a benefit to pollinators at all is very much up in the air, while it's almost certain that the substitution is more harmful for mammals such as ourselves (neonicotinoids have very low mammalian toxicity, unlike e.g. organophosphates, which are closely related to nerve agents).

Comment Useless warnings are useless. (Score 1) 59

The problem you get though is what I call the "California Cancer Warning Problem"
Basically, people can only pay attention to so many warnings. The more often people get false or trivial warnings, warnings where they have to continue to get things done as standard, the more likely they are to just plain ignore the warnings.

While hackers might be able to figure out a way to do something malicious without triggering the warning, the warnings back then were worse than useless, because they not only triggered for just about every document, users by default could not assess the document for safety without enabling the scripting. IE I couldn't by default open the document and look at the scripts to assess them (and some of them were only like a dozen lines) without enabling them.

Saying the warnings were necessary also ignores that there have been exploits that didn't even require opening a document to cause infection. Preview was enough.

Basically, if the hackers figured out something clever, just add that to the check. It would still be a better situation than what we had back then.

Comment Laws for slavery (Score 5, Insightful) 192

I’d argue that slavery wasn’t “legal because nobody banned it.” It was legal because there were explicit laws that created, defined, and enforced the institution.

There were statutes specifying who could be held as slaves, rules that the child of an enslaved woman was automatically a slave, procedures for manumission, regulations on how slaves could be bought, sold, punished, or inherited, and laws requiring that escaped slaves be returned. That’s not a legal vacuum, that’s a full legal framework.

It’s similar to how segregation laws later forced discrimination on people who might not have engaged in it otherwise. The state wasn’t passively allowing something; it was actively mandating and structuring it.

Slavery existed because the law built and maintained it, not because the law failed to forbid it.

Comment Re:Please don't (Score 1) 59

I remember those days where it would warn if there was any scripting at all, rather than look for dangerous commands first.
Just as a thought, not bothering if the script cannot reach outside of the document itself. Functions that access other files or documents, email functionality, and such triggering the warning instead would have been more effective.

Comment Re:To be honest ... (Score 1) 29

Well, when I read it was all pounds, in Europe, I wondered how much that is in kg. As I am lazy, I just divided by 2 ... but the result was a kind of odd number, so I lost a few bits of accuracy.

More than a few bits. You can still be lazy by dividing by 2.2 and get a much better answer: 800 kg.

Now I only have to figure what exactly -half a thousand degrees Fahrenheit is. I guess I can google for an AI to find that out.

I gather you went to high school somewhere other than the USA. Did you not learn C = (5/9) * (F - 32)? That yields about -267.77 C, or about 5.4 K (by adding 273.15.) In other words, close to as cold as you can possibly get.

And "exactly -half a thousand degrees Fahrenheit" sounds oxymoronic. Just saying.

Comment Re:Looks like panic to me (Score 1) 79

Liked your post. I'd add a mention of the book Empire of AI by Karen Hao, which I just finished reading. It's a fascinating study of the rise of OpenAI and the impact of the needs of the AI industry for data and compute-power.

Sam Altman doesn't fare well in the book. He comes across as a duplicitous Napolean-fanboy, who nevertheless managed to develop a cult following amongst his employees. A following that has eroded over time but is still holding. Many ex-OpenAI employees have gone on to create rival companies, including Anthropic.

As for OpenAI ignoring specific areas of the market where AI can create revenue: they never really had that focus. They began as an altruistic effort to produce AGI for the human race, and bit by bit, their mission was compromised over time. They took on VC funds with some strings attached, and pleased their backers with some relevant products (see Copilot for example.) Now they have shed their altrusitic non-profit ambitions, but they continue to appear to be fixated on achieving AGI no matter what.

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