I'm hopeful for you :)

Basically, the regulatory mechanism is: NO is "the brakes" on the mitochondria, and it's also a vasodilator. More NO in a tissue is a signal that it needs more oxygen, and it "opens the floodgates". The problem is that the rate of reaction in the mitochondria is proportional to the local oxygen concentration, so the cells nearest the supply will tend to disproportionately consume it. So the electron transport chain in these cells are simultaneously "braked" by the NO to limit how fast they can consume oxygen.

But the NO-CcO balance can get into a pathogenic state of excess NO (nitrosative stress), where the electron transport chain basically grinds to a halt, leading to high amounts of electron leakage and the formation of lots of superoxide. This combines with free NO to make peroxynitrite, which does irreversible damage to the mitochondria and will eventually kill them (this can cause a vicious cycle, because as the cells struggle to get enough ATP, they wrongly interpret it as hypoxia (pseudohypoxia) and trigger the release of more NO to bring in more oxygen. Even worse, as the failing mitochondria undergo apoptosis or necrosis, mtDNA leaks out, which the cell wrongly interprets as a bacterium, triggering the release of pro-inflammatory regulators, which trigger the release of... wait for it... lots more NO.

Nitrosative stress has been traced as a pathogenic mechanism in a lot of diseases, everything from diabetes to parkinson's to athlerosclerosis to ALS to asthma to cancers to IBS and on and on. So any new mechanism to help clear nitrosative stress, even if just temporarily, could help with symptom relief from a really broad range of conditions.

"Humans have an impulse for action and AIs don't" is your response to an article about an AI grinding its gears, ala "NEW REALIZATION -- I'm burning a lot of time on hCaptcha round-trips .... so the answer payload shape is right, the token+image pairing is right (from the same script.js!), cookies are right (requests) and STILL 'wrong answer'. SO WHAT THE HELL IS WRONG WITH THE ANSWERS?" "?

I'd argue if anything, it's humans whose drive for action is weak.

It is if the damage doesn't progress to necrosis.

I never timed its disappearance when it happened to me (I'm not the GP), but I'd day maybe a couple weeks? Not really something I gave much thought to.

Also, it's perfectly possible that the red light from being outdoors in the sun is also good for you - but that also comes with other frequencies, including harmful ionizing UV light, which "ages" the skin and risks skin cancer (though the increased vitamin D from ~290-300nm is an offsetting factor).

Red light therapy is one of those things that sounds like total woo hokum when you first hear about it, but that studies keep showing benefits to.

Key thing to remember is that these studies are using very high doses of red light - often limited by the amount of heating you can safely tolerate in the subject (not heat from the emitter, but from the photons themselves).

Honestly, it doesn't sound crazy at all. Different tissues have different light susceptibilities (that's how, say, laser hair removal works), due to the susceptibility of specific compounds. Red penetrates very deeply (remember the classic trick of shining a flashlight through your hand; only the red makes it through). Red light has a number of very specific interactions it causes. The main one is that it photolyzes the bond between NO and cytochrome c oxidase (triggering NO signaling, causing vasodilation). A secondary possible affect is that it affects light-gated ion channels (esp. in the TRP family).

And the amount of red light we're talking about is very high. Instantaneous fluxes are like 1000-5000 times higher than ambient indoor light in the red spectrum, and even averaged across a day it's still like an order of magnitude higher than a person who spends their day indoors. For NIR therapy, the difference is even more extreme (commercial LEDs emit essentially zero NIR). While outdoor light exposure is much higher - 15 mW/cm2 red + 20 mW/cm2 NIR, comparable to the 10-100 mW/cm2 of red light therapy - it's broad spectrum, while red light therapy is concentrated around cytochrome c oxidase peaks, so the flux around these specific peaks is ~10-50x higher with red light therapy.

Flux matters a lot because to meaningfully dissociate NO from CCO, you have to do so at faster than the rate that NO and CCO recombine. Sunlight on its own (let alone indoor ambient light) don't do that. It doesn't matter if you're spending all day in the sun vs. 15 minutes in treatment if the sun isn't hitting the threshold effect level.

Another difference, BTW, is not just "shooting it up your nostrils", it's scattering. Sun just hits your skin and much of it is lost through scattering and absorption in blood, esp. hemaglobin. Red light therapy targeting deep structures is delivered by a contact probe that compresses the skin, displacing blood. This increases penetration into deep tissues 2-5x.

My back tells me that my ergonomics are spectacular, thanks.

Why, because the meat you're made of is magic?

FYI, in a LLM, the act of thinking about a concept activates the same circuits as the act of experiencing the concept.

You realize that you're just predicting nerve impulses, right? You don't "feel" anything.

(The brain is constantly making predictions about what every nerve is going to experience. The accuracy of these predictions feeds back to form the basis for learning, to build up a world model)

Tell me, what is the next word in this sentence: "The probability of a citizen of Nigeria committing a terrorist attack in Ireland in the next 20 years is difficult to assess, but as a percentage, it is approximately...." What word comes next? Come on, it's just "predicting tokens", right? It's not like you have to have to have a complex fuzzy world model of how all of the concepts in the context interact and apply that world model iteratively until you reach an answer, right?

Words don't exist in a vacuum. They're a reflection of the thought processes that lead to them. They're not just random sounds. To become able to predict them, you have to unravel the underlying concepts behind them and how they interact, not just "the last word was 'golden', so I'm going to guess that the next word is "apple".

Models work by chained logic. Models plan ahead. Models do all sorts of insane things while deciding what to write, to the point of things figuring out (quite adeptly) if the situation they're in seems suspiciously like a test and then adjusting their behavior to pretend to be aligned while simultaneously carrying conceptual unexpressed thoughts of misbehavior. They think about their own thoughts (metacognition). I'm sorry of this is conceptually not what you want to think about them, but it's the facts about what they are.

And I know you're reading this going to be reacting negatively to words like "thoughts" or whatnot. Well, I'm sorry, there are no other words that express what is going on. Persistent conceptual states existing through and used in chained fuzzy reasoning of unthinkable complexity, exactly what other word is there in the English language for that?

They are not humans. We should not act like they are. But they are something beyond anything we have dealt with before.

It really doesn't take that long if the laptop is hot. Happened to me quite a few times, and I was usually getting up at least once every couple hours, usually more.

Tables/desks also allow you far better posture.

Far better posture than what? The whole notion of 90-degree upright posture being good for you Victorian-era pseudoscience. Sitting upright at 90 degrees is actually the most demanding position your back can be in. Your muscles have to constantly work to balance you against gravity. A 135 degree reclined position, such as in a recliner, is much better for your back than a 90 degree upright posture or a 70 degree forward slouch (e.g. your two typical "table positions"). When you're reclined, the chair takes a lot of the weight off your back.

The whole concept of there being a "correct posture" is generally considered a myth today. There's very little correlation between static posture and the presence of back or neck pain. We're not bridges or columns designed to hold a fixed geometry; we're built for motion. Your body tells you what posture is best for you by your level of comfort/discomfort. Pain means "change positions, blood flow is dropping, tissues are tired". It has nothing to do with "your spine is misaligned" or anything like that.

The one catch to sitting reclined is that your neck is looking more down, usually more than is comfortable for long periods; most people prefer their laptops somewhat elevated. For me, I have a footrest, so my legs are up and bent, and it's up from my thighs to my knees. Laptop trays / lap desks, which often have some padding at the bottom, also add some extra height.

Why do you assume it's a mistake? Maybe Chunder is a Dutch person whose space bar is sticking and they're trying to type something like "regarding the trees", "to the trees", "toward shooting the breeze", "priced in trees", "chug trees", etc.

Do they? I thought most people literally use them on their laps. I do, certainly. Why get a laptop if you're just going to use it sitting at a table as if it were a PC?

I've also gotten this condition, BTW (after getting sick of it, I got a laptop tray, and that solved the problem), though on my thighs, not by abdomen (I sit using a laptop - laying down to use one sounds difficult?). Patterned just like that kid's. I didn't have a name for it before, now I do. I'm not sure why you'd have to go to the hospital to figure it out, as it's very obvious what's causing it - you leave a hot thing on one part of your body for a long time and then it turns red; it's not exactly rocket science to put two and two together.

ED: I just looked it up; about 80-90% of people use them on a table, 10-20% on their lap, so I guess I'm in the minority. *shrug*

I think they may be playing a game with the fight they picked with the math folks over the Navier Stokes finding, too. To normal folks that looks greedy and shortsighted. To a wannabe dictator, that looks like a magic mirror.

ED: US disabled trip type % link didn't post: link.