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Comment GLP1 - The Ozempic Effect (Score 3, Interesting) 132

GLP1's are the Wonderdrug of the century:

While clearly awesome for weight loss, much of the "beyond" benefit is still being untangled as either a direct drug effect versus downstream consequence of the weight loss and metabolic improvement itself. Many clinicians describe seeing improvement across cardiovascular and metabolic comorbidities "probably due to both weight loss and direct effect of the medication. Most of the newer findings are associational, not proven cause-and-effect.

  • Slowing Biological Aging: A landmark June 2026 study published by the U of Cali found that semaglutide slowed the pace of biological aging by roughly 9%. This is driven by reductions in chronic immune activation and metabolic stress
  • Type 2 Diabetes - a 2% A1C reduction and 16.8% weight loss.
  • Liver: Semaglutide outperformed placebo in treating advanced fatty liver disease (MASH/MASLD) in a trial
  • Cardiovascular Health - cardioprotective effects independent of weight loss,
  • Improved cholesterol, blood pressure, and inflammation metrics
  • Brain Health - Neuroprotection: Animal studies suggest semaglutide may counteract memory loss associated with Alzheimer's disease by reducing brain inflammatio
  • Pain & Motivation: A mouse study showed GLP-1s can ease pain and reduce the motivation to exercise (studies underway)
  • Addiction: Early studies suggest GLP-1s may help reduce cravings for substances like alcohol and nicotine
  • Sleep Apnea: Tirzepatide was approved in 2024 to treat obstructive sleep apnea
  • Bone: Evidence is mixed-some studies show neutral effects, while others suggest glp1s may enhance bone formation in certain populations
  • again Immune System: They exert broad antiinflammatory effects that reduce the risk of secondary infections and inflammation-driven conditions, such as sepsis and cellulitis.

With estimated 50million US having been on GLp1's in the last 5 years, that more than accounts for the bump in life expectancy.

Comment Age Verification is a Win Win for AI Services (Score 1) 54

This is about forcing their competitors (google, tiktok, meta, twitter, etc) to invest in validation of users identity before allowing public posting on those services.

Meanwhile, OpenAI has no public posting capability and is not required to authenticate users age. It also is mostly pay-for-play and one of the top users of AI are kids under 18,.

So, either Google/Meta socials validate users - which wont happen - and users gravitate to AI for 'time spent'. It's a win-win for AI services.

Comment Re:what? (Score 1) 28

Really, maybe Echelon was out before you were born. YOu've prolly heard of Flock - ring door bells - hundreds of exploited smart home devices. The ties between the top phone companies and the govt, go back well into the hard line era. Can llms make all that work better - surely - but whether that LLM is from anthropic, openai, meta, or downloaded from the local warez site, is a moot question. I now wonder - in the wake of the personal attacks on Altman - if Anthropic walked way from a deal with govt only to cast stones at competitors. Not crazy about openai myself, but atleast it was zuck.

Comment Gas lighters (Score 0) 28

They've had about five years in the public eye (3 since Chatgpt tipped) to show us evidence of some grand threat or bad outocme by AI. The threat from software at this point is radically over stated. But boy, gas lighting the public, sure is profitable aye Dario? Nothing like scaring people into giving you a hundreds billion eh?

Newton Crosby: It's a machine, Schroeder. It doesn't get pissed off. It doesn't get happy, it doesn't get sad, it doesn't laugh at your jokes.
Newton Crosby, Ben Jabituya: [in unison] It just runs programs.

Comment Search Is Up Because Search Quality is Down. (Score 1) 59

> Web search queries are up industrywide

Nobody can find *hit on the first search, so they have to click again. You are sucked into clicking on "classic search", "people also ask", "click here to open", to try to get away from Google Spam and all that then counts as two searches for Google.

Comment Re:And Automattic continues to circle the drain (Score 1) 23

> exact feature

No body wants that. 50% of wordpress is never touched and the top plugin of the last six months is 'classic editor'. Also a good chunk of it could be replaced with open source apis (rest, etc)

You might want to take another look at AI coding. I've churned out 20 commercial plugins the last year, and I consider myself a entry level at php (my main jam is c, vb, ml, perl coding).

I had AI clone the entire wp classic editor system with all DB access into Perl for a site that only allowed Perl. Took less than an hour to get running right (prolly 4meg of code).

Seriously, we are close to being able to full clone Wordpress with a rewrite in a short amount of time. I still think AI cloning wordpress, is easier than doing the C compiler (ai is better at PHP than C). I bet a team of 3-4 guys that know PHP and Ai could clone it in under a week into something like Perl or Python.

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