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Comment Re:Gut flora and artificial sweeteners (Score 1) 5

This is probably the most recent, well-cited article on the topic. The authors looked at the effects of saccharin in mice, and were able to determine that there was a significant elevation in blood-glucose level for the mice that were fed saccharin instead of actual glucose over the course of nine weeks. This suggests a mechanism for previous findings that suggest artificial sweeteners cause insulin insensitivity, weight gain, type II diabetes, et cetera. The difference between the two diets went away when both groups were raised with antibiotics, strongly suggesting the underlying cause was gut microbiota. They also found evidence that the saccharin diet led to changes in gut microbiome composition:

In agreement with the experiments with antibiotics, next generation sequencing of the microbiome indicated that mice drinking saccharin had distinct compositions from controls. This distinct microbiome was characterized by enrichment of taxa belonging to the Bacteroides genus or the Clostridiales order, with under-representation of Lactobacilli and other members of the Clostridiales. Several of the bacterial taxa that changed following saccharin consumption were previously associated with type 2 diabetes in humans.

Keep in mind that everyone has different gut flora, so in general these impacts will vary from person to person, which is why the effect is inconsistent, as with obesity and type II diabetes in general. I can't say for certain that these results would directly transfer into humans, but since the bacteria are the same, it's unreasonable to assume they wouldn't. Less clear is whether this effect transfers to other sweeteners; the paper includes a table showing a number of studies pertaining to a diversity of chemicals, some of which found an effect, and some of which didn't.

Non-professionally, my advice would be to avoid artificial sweeteners, and ideally all liquid candy. Some people find that drinking normal, sugary soda produces a state of lethargy, and I'm pretty sure this is a result of the long-term exposure to sucralose. It's sort of a trap!

Comment Re:Baddly worded summary (Score 3, Insightful) 80

I suspect this may enable them to lower their prices or increase their margins.

Linux support on popular high-end hardware is close to flawless -- or becomes so after that hardware has been out for a year or so. But if you start looking at the plethora of low end laptops, especially, you are in for a world of minor headaches. I find it takes me about a week of research to get a cheap, relatively new laptop working flawlessly. Sometimes the fixes Google turns up for your model don't work because you have a different revision number. Most people, if they attempted to install Linux onto a recent, low-end laptop, would find a lot of things not working, like sound, or keyboard special keys. It's not rocket science to fix, but for them it might as well be.

This is not what 99% of the world signs on for when they buy a laptop, so it makes sense for someone to have a business that does this for people. But if you're in the business of doing that, you have to pay yourself for your labor. That means you can compete at rock bottom prices because that's where you're starting from in your costs; and in any case starting with a better quality device minimizes the work you have to do dealing with stuff like broken ACPI firmware.

Which means when you count the cost of your value added, it's really hard to sell a rebranded laptop at a competitive price. Selling high quality rebranded hardware at relatively high prices and small profits may be a way to bootstrap your business, but the only way to get serious volume sales at a profit is going to be to have a computer manufactured to your specifications.

Comment This might offset *warming* but not *change*. (Score 1) 226

Most of the greenhouse effect warming takes place in the summer, for the simple reason that's when the most solar radiation is received and trapped. This doesn't eliminate that effect, it offsets the increase in the *average* by adding an unnaturally cold winters -- which by the way would increase fossil fuel use dramatically.

Now this would -- if it is physically and economically feasible -- blunt *some* impacts of global warming, such as glacier retreat and sea level rise. But it would accelerate *other* effects, such as habitat loss and changes in rainfall. Other carbon driven changes like the emergence of carbon-loving weed populations would continue unabated.

Consequently assuming that it's practical, its effects would be at best mixed, and there would be some big-time winners and losers. People with a lot of money in waterfront property would be big winners; interior farmers who rely on historical rainfall and summer temperature patterns would lose. Trout fisherman would lose as warm-water species outcompete salmonid species in their historical range. Etc.

These kind of problems are inherent in any attempt to treat the *symptoms* of rapid, anthropogenic climate change. I you aren't going to use conservation and efficiency to attack the problem, then the most promising geoengineering solution is carbon sequestration -- if it can be achieved on the scale needed. In the ideal case you would set the CO2 levels back, say, to 1960s levels. Not necessarily pre-industrial, because people have already adapted to changes from pre-industrial levels, but low enough that the rate of climate change is closer to natural than what we have today.

Comment Re:On-site service; cargo (Score 2) 205

Yes, but few strength training exercises require sticking your ass up in the air and waving it back and forth like that.

Straight leg dead lift. bent rows, and back hyperextension off the top of my head. And while we're on the subject of distracting and embarrassing, there's always leg abduction.

Anyhow, people are jerks toward anyone who gets serious about anything, whether it's biking, power lifting, or building electronics. You're supposed to be normal, not exceptional. That makes it easy to be a sanctimonious prig toward people who like things you don't have what it takes to try.

Ever go to a gym where there's rules about making too much noise because you'll scare the casuals? It's stupid. There's a woman in my gym, an ex-marine, who can dead lift over 2 1/2 her body weight, which for a woman puts her in the elite range. When I walk into the gym and she's doing it, I have to walk out because she sounds like a harpy ripping the head off a dragon. But it's my problem, not hers. That's what it takes for her to do her thing, and I'm not going to make her feel bad about it because it's awesome. Literally.

Celebrate people who dare to look, sound, or even be ridiculous. Even if it bothers you, that's not the same thing as harming you. The people who do harm are the self-appointed conformity police. The ones who automatically go after anyone who doesn't appear normal. "Normal" is must another word for "mediocre".

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