When I've been a manager hiring fresh graduates I've normally required the applicant's transcript. I accept an unofficial copy but it must match the "official" copy acquired during the "background check" portion of the process.
I usually pay little attention to courses outside of STEM unless grades in those are consistently B or below. I also pay little attention to freshman grades if sophomore and higher grades are significantly better (after all, such improvement shows the ability to, well, improve and perhaps the willingness to try new things, including destructive ones, that were not readily available in the environment they grew up in). I'm somewhat curious why someone got a C in both Comparative Gender Studies and Russian Literature but I mostly want to hear the explanation of why the applicant got that grade rather than the grade itself.
I do pay a LOT of attention to performance in core CS classes - in fact, with possible exceptions for freshman grades, unless it's a very top-tier school the GPA in those courses must be close to 4.0 - especially in programming classes. I do forgive a lower grade in isolated cases where (after talking to the applicant) it turns out the course grade was primarily based on graded "group projects" and it seems that the candidate was likely dragged down by their group's incompetence. However I want to know why the candidate didn't realize the problem early and why they didn't just grab the reins and do the project themselves in order to get a better grade and not worry too much if they were also enabling "free riders".
However, it would be very helpful for the transcript to have, next to the grade, an indication of where the student's grade sits among grades issued in that section of the course (perhaps the percent of the students in the class getting a lower grade but excluding those who failed the course). If the candidate got a B in Analysis of Algorithms 101 but 90% of the class got lower than a B, that's much different than if they got an A but only 10% of the class got lower than an A as in the former case there was differentiation I can rely on while in the latter there is no useful differentiation so I would pretty much ignore that grade as meaningless.