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Comment The more things change... (Score 1) 35

The more I love The streaming service continues to be semi-lame (never seems to have what I want). And the ratings and general listing UI has done nothing but get worse for the past 10 years. But queuing up a dvd and have it arrive in a couple of days is solid. And cheap.

Comment Re:We fucked up. Bad. (Score 1) 51


A thousand times this.

Since their competitors have failed to voluntarily participate Samsung will take it to Washington next; lobbying Congress and the FCC to erect a (another?) battery safety bureaucracy complete with $250k certification fees and a special "fast lane" process for the well healed. Never let a fuck up go to waste.

Comment Re:Probably a minor oversight. Will likely be fixe (Score 5, Interesting) 214

Microsoft has actually done a good job with Visual Studio Code.

If you're willing to completely dismiss performance concerns then yes, great work. On the other hand, if you care about performance, and memory usage, it's pretty hard to do worse than VSCode without including including something like Eclipse or Intellij in the survey.

Comment No. p53 - the guardian of the genome. (Score 1) 123

All mammalian cells are constantly producing p53, and disposing of it. When they stop, repair or suicide should occur.

Once activated, p53 will induce a cell cycle arrest to allow either repair and survival of the cell or apoptosis to discard the damaged cell. How p53 makes this choice is currently unknown... First, the half-life of the p53 protein is increased drastically, leading to a quick accumulation of p53 in stressed cells. Second, a conformational change forces p53 to be activated as a transcription regulator in these cells....

Comment Quercetin (Score 1) 123

About a year ago it was discovered that the common dietary substance quercetin is able to kill senescent endothelial cells in the gi tract.

By transcript analysis, we discovered increased expression of pro-survival networks in senescent cells, consistent with their established resistance to apoptosis. Using siRNA to silence expression of key nodes of this network, including ephrins (EFNB1 or 3), PI3K, p21, BCL-xL, or plasminogen-activated inhibitor-2, killed senescent cells, but not proliferating or quiescent, differentiated cells. Drugs targeting these same factors selectively killed senescent cells. Dasatinib eliminated senescent human fat cell progenitors, while quercetin was more effective against senescent human endothelial cells and mouse BM-MSCs. The combination of dasatinib and quercetin was effective in eliminating senescent MEFs. In vivo, this combination reduced senescent cell burden in chronologically aged, radiation-exposed, and progeroid Ercc1/ mice. In old mice, cardiac function and carotid vascular reactivity were improved 5 days after a single dose.

Comment Re:No Crime (Score 1) 225

I don't know what 'violently protesting' means

I don't either. The thing is our mutual ignorance of the meaning of that bit of media speak isn't terribly relevant. The rioters have actually been charged with crimes; Felony Rioting, specifically. Here is the actual statute:

And perhaps the most relevant part of that is:

If in the course and as a result of a riot a person suffers serious bodily harm or there is property damage in excess of $5,000, every person who willfully incited or urged others to engage in the riot shall be punished by imprisonment for not more than 10 years or a fine of not more than the amount set forth in 22-3571.01, or both.

So any riotous trustafarian that texted any of their follows in a manner than that appears to incite or urge is a felon. Just yelling or holding a sign can get you there; all the prosecutor needs is some evidence. That's where all the phones come in.

Some folks got use to having their way with no push back under Obama. As these rioters and others (Dakota Access squatters, for instance) are learning, the worm has turned. The next Ferguson is going to be very different.

Comment In other "protest" news... (Score 0) 225

The "March for Science" is floundering as various grievance groups push their diversity agendas into the fore. The event's "official diversity policy" is now on its forth revision amid the resignations of organization committee members.

Some are concerned the event will — much like the vaunted Women's March — have conspicuously white optics. Others are concerned the March for Science is losing focus as sundry aggrieved interests try to attach themselves to the imprimatur of "science." In all likelihood they're both right.

Comment Re:Because Manufacturers Suck (Score 1) 100

Blackberry cares... at least as a business model.

My PRIV has had *monthly* updates. That's the best I've heard of.

My phone is basically ASOP, with some added security and Blackberry calender, etc.

Overall.. not bad. Lots will badmouth BB, but they've come far now that they're pure android.

Submission + - SPAM: Quicken Bill Pay is No Longer Safe to Use 1

Bruce Perens writes: I don't usually make security calls, but when a company makes egregious and really clueless security mistakes, it's often the case that the only way to attract their attention and get the issue fixed is to publicize it. This one is with Quicken Bill Pay, a product of Metavante (not Intuit). It's from personal observation rather than an expert witness case, and the company has been unresponsive through their customer support channel.
Link to Original Source

Comment Abandoning Time-Worn Processes Leads to Atrophy (Score 5, Insightful) 158

Scientists determined that those people who made use of machine washing rather than hand washing had diminished hand strength and neurological motor communication necessary for fine motor control. Seamstresses who bought thread rather than using the spinning jenny were similarly impaired. But worst off were teamsters who used the internal combustion trucks rather than teams of horses and used forklifts and other mechanical devices rather than loading their vehicles by hand. Their overall body strength was much reduced.

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