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Medicine

Non-Invasive Stimulation of the Brain Ended Opioid Addiction, Cigarette Craving (jpost.com) 14

The Jerusalem Post reports that doctors at Haifa's Rambam Health Care Campus "have successfully treated their first Israeli opioid addiction patient using an experimental noninvasive brain technology, easing him through withdrawal in just 20 minutes..." [T]he team of specialists at the Haifa medical center intervened in the electrical activity of an area of the patient's brain called the nucleus accumbens, the core of the brain system responsible for feelings of satisfaction, pleasure, and reward. The treatment, based on technology from the Israeli company Insightec, is similar to the one used to treat symptoms of essential tremor and Parkinsonian tremor, under MRI control. In this case, the treatment was carried out with the help of a new technology that performs noninvasive neuromodulation, without heating or burning tissue, and allows stimulation in the same area of the brain to increase or suppress activity...

"Tests carried out a week later produced negative results for opioids and other substances," [said Dr. Lior Lev-Tov, director of the functional neurosurgery unit in Rambam's neurosurgery division and the one leading the new study at the medical center.] "The patient himself reported a craving score of zero out of 10 for using the drug, and even another side effect, a drastic drop in the desire for cigarettes, from three packs a day to just a few cigarettes, and with no urge to use alcohol. In other words, in a treatment that lasted about 20 minutes net, our patient was completely freed from an extreme dependence that had accompanied him every day for years. This is nothing less than a medical and therapeutic revolution."

Dr. Lev-Tov added that "This experience opens doors for us to treat a wide range of very serious illnesses such as PTSD, OCD, eating disorders, other addictions, severe depression, severe pain disorders, and I hope we will also be able to reach cognitive areas and treat attention deficit disorders, Alzheimer's, Parkinson's, and more."

Thanks to Slashdot reader Bruce66423 for sharing the article.

Comment Re:Would a Spar be Repairable? (Score 1) 60

Replaceable? No. Reparable? Depends on the extent, but even that's hard: the wings are full of hardware, and if you have to spend a year and invent a process for dismantling everything to get at the damage, it becomes financial infeasible. Even if you pull it off, you have new inspection requirements, operational limitations, etc.: it's not the same revenue generating plane after something like this.

There is a lot at stake. Emirates operates these with over 500 passengers. If that manifest burns to death on takeoff because a wing folds there will be hell to pay.

Comment Re:Vizzini (Score 1) 77

I think the end state of all this looks like game cartridges. If people could buy the weights of a frontier quality model in a high density, high speed ROM that ran locally plugged into an PCI-E or M.2 slot, all you would need then is a reasonably fast tensor processor with a little RAM for context. This is possible, and there is even a company (Taalas) with an early product. They have an online demo that is crazy fast.

You would buy one and use it for some time, probably years, and then discard it when the value of some newer version makes sense to you.

Comment Re:This. (Score 1) 86

I had one breakthrough DMT experience where I saw 'the machine elves' (I just saw what I describe as fast-moving fractals that I 'felt' were beckoning to me); but, we have matching experiences w/the other primary psychedelics: I only had relatively minor on-top visual distortions with even the largest doses of LSD (1500+ mcg) or mushrooms.

That said, everyone is different. I know that some of my friends absolutely lost their fucking minds on a few tabs of LSD and, purportedly, experienced wild hallucinations that I have to trust were real to them but haven't ever experienced myself.

Comment Foundry business (Score 4, Interesting) 23

Not surprising. Tesla is its 5th generation (AI5) processor, currently manufactured by Samsung and TSMC. I suppose they imagine there are others that will want to use these for their own purposes. Musk is creating his own supply of chips for SpaceX at his TX Terafab. Having terrestrial customers to absorb some of the supply and provide revenue as that ramps up the obvious thing to do.

Comment Re:Wow (Score 2) 73

we're fucked

Perhaps not. There are Chinese fabs that can't make HBM, but can make DDR5. Corsair is now (as of about 2 weeks ago) selling modules with CXMT RAM. That's the first time one of the "major" RAM module manufacturers have turned to Chinese chips.

That may be the answer to the DDR5 shortage over the next year or so.

Comment Nice (Score 2) 28

Great. New fab in the West. It's just power stuff; silicon carbide FET and whatnot. Still, if concern for "sovereignty" is what it takes for bedroom community Europe to get off the dime, then good for them. Better than being industrial vassals of the US, China and Russia, which is where they've been heading. Feel free to make more "sovereign" fabs.

Comment Re:Question (Score -1, Troll) 48

From outside, an IR imager should be able to see the heat from a leak. But who knows; one would imagine if it were that easy they'd have done it 7 years ago, when this crap Russian module's chronic leak issues began. My inner cynic thinks this is probably political; competent people aren't being permitted to deal with it.

They'll deal with it when some hatch or docking port blows out and sucks a couple people into space wearing NASA tee shirts. I'm rather certain about that much.

Comment Re:IPO for billions, sells for millions later. (Score 1) 36

The IPO push is tied to their profit forecasts, and they expect to be profitable in Q2. They're revenue is growing rapidly and it's likely true they'll actually turn their first profit, so don't bet against it.

I guess its all those multi billion dollar dot coms that were later sold for a fraction of their IPO valuation

Sure. That could happen again. And again. It's even likely with these LLM operators. A few years from now the necessary hardware be lower cost and lower power. The models they've built will be cloned and surpassed by multiple competitors.

But in the immediate future investors will fill Anthropic's pockets. One benefit in all this is that there will be more scrutiny of the spending, which will create friction in the both the Buy All The Silicon and Datacenters Everywhere departments: the investors of both Anthropic and OpenAI will want to milk the value of tokens while spending as little as possible and avoiding risk.

Comment What a funny thing to say (Score 1, Informative) 86

What a funny thing to say about something that is literally all text. Match up the code itself with the commit message and the ticket that caused it to happen - we work in the most documented business there is.

If you don't force/write good commit messages then you get what you deserve.

If you don't force/use good issue tracking then you get what you deserve.

In general, AI now composes my commit messages. Then I delete 2/3 of it. Sometimes I'll touch it up a bit. So it is helping our process...

For every line of code in our repo I know who wrote it, when they wrote it, what they said about writing it, and why they started to write it in the first place. If you don't know those things then you (or your organization) are doing it wrong.

Space

Blue Origin Rocket Exploded Thursday Night During Hot-Fire Test (cbsnews.com) 73

Spaceflight Now shared their video of the explosion, which the Orlando Sentinel describes as showing Blue Origin's rocket "become engulfed in flames. The fireball expands out and covers the entire launch pad as the fuselage of the rocket can be seen crumbling into the flames."

Blue Origin founder Jeff Bezos said on X.com "It's too early to know the root cause but we're already working to find it. Very rough day, but we'll rebuild whatever needs rebuilding and get back to flying. It's worth it." (SpaceX founder Elon Musk posted "Sorry to see this, I hope you recover quickly.")

It's unclear how this will impact future launches. "The rocket was destroyed," reports CBS News, "and as the smoke cleared, there was no sign of the erector-gantry used to move the New Glenn from its hangar to the pad and to raise it from horizontal to vertical. Likewise, one of two tall lightning towers was no longer visible." It was the first such on-pad explosion at the Cape since a SpaceX Falcon 9 rocket blew up on nearby pad 40 on Sept. 1, 2016... Blue Origin only has one New Glenn pad, the one that was damaged in the Thursday test. The New Glenn, which has launched three times, is a heavy lift rocket designed to compete head-to-head with SpaceX Falcon 9 and Falcon Heavy rockets. During New Glenn's most recent flight in April, an upper stage malfunction prevented a commercial internet satellite from reaching its planned orbit...

The New Glenn destroyed Thursday was to send 48 Leo internet satellites owned by Amazon into space [which were not on board for the hot-fire test]

Blue Origin posted on X.com that "Debris from our recent hotfire anomaly may wash ashore in the coming days/weeks. If you encounter any debris, do not touch or approach it for your safety."

"Spaceflight is unforgiving, and developing new heavy-lift launch capability is extraordinarily difficult..." NASA Administrator Jared Isaacman posted on X.com. "âWe will provide information on any impacts to the Artemis and Moon Base programs as it becomes available."

Thanks to long-time Slashdot reader symbolset for sharing the news.

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