Start going after the desktop market , or at least some of it, with Steam OS 3 public release?

No way ;)

Herr TrumpenFührer and spawn wouldn't *lie* about their commitment to manufacturing the TrumpenFührer 1 (T1) phone in the United States.

*Clutching at my pearls.* In any other company, I'd say the principals made the decision to announce manufacturing in Los Estados Unidos de Norte America, completely failed to listen to their experts that it's impossible to manufacture mobile phones in the United States of North America without losing money on every handset.

You agree to an audit, as part of the license agreement.

I mean sure, the average layperson is gonna fuck it up. But what about professionals, e.g., a PhD scientist?

I use LLM-based models for lit searches (typically, these are dedicated tools for lit searches, but I have tried it on ChatGPT). I don't use the summaries, but I do use the lists of papers it comes up with and generally go through them in whatever ranking it spits out.

Works pretty well, saves a ton of time in *starting* lit searches. Still have to do the reading. The AI sucks at interpreting papers, wouldn't ever trust it as it stands now.

Anyone else on an iPhone?

No. People without cognitive decline may not yet have experienced it. Amyloid is also involved (as is tau) in other neurodegenerative diseases. To dismiss it so blithely is a testament to how much you donâ(TM)t know.

What a bunch of unscientific gobbledygook. Get the fuck out of here with that weakass bullshit hearsay. Show me fucking literature that matters, with pubs in high impact factor journals by reputable authors with tons of citations and references of the same. Build on the shoulder of the giants who came before instead of being a rando layperson dumbass who thinks that they alone can solve all of the complex medical problems of the world alone through their own unique sheer genius.

Hi! Um... no. Definitely not. Sorry. Highly unlikely to be at all relevant, or even true.People get amyloid even without parasites. Or without showing cognitive decline! It is more complex than pretty much anyone in these comments is indicating.

Hi, scientist overseeing clinical trials involving AD! I wouldn't say the jury is still out on the importance of amyloid as a biomarker in assessing AD progression and response to treatment. Patients using the now FDA-approved anti-amyloids had statistically significant reduction in rate of decline as compared to placebo, assessed by cognitive tests. They also had reduction in amyloid load, as assessed via amyloid PET.

The previous 20 years may have failed. That doesn't mean today's drug pipeline is also going to fail.

Castillo de San Marcos - Built at Sea Level in 1672.

Castillo de San Marcos - Still at Sea Level in 2025.

If/when true AGI is achieved, only a fool would announce it. What would announcing it do for you? Make you famous? Rich? Cool. Know what's better than all that?

Not telling a damn soul and using the AGI quietly to do whatever the Hell you want. If you want to be rich, the AGI will tell you how to become rich. If you want to be famous, the AGI will tell you how to become famous. You can do both. And you don't have to stop there. A real, vastly superior AGI enables the person controlling it to do anything. The second you tell people about it, you'll lose control over it and then you're the famous idiot who did a cool thing one time. Kids in elementary school will recite your name back on a test. And you could have had everything.

Anyone smart enough to crack AGI can't also be stupid enough to advertise when they do it.

Sure, if they implement an $800 ICE tax simultaneously, I'm good.

My 1969 Mustang Grandé with an Edelbrock intake and a Holley double-pumper drinks a bit more than the original 4 barrel carb and factory intake. It takes Premium only, but hey - build a viable EV infrastructure and I'll drive a slot-car too.

There's a lot of interesting points you make, but also a lot of incorrect assumptions. A recent Yale poll indicated that 18 to 21 year olds lean Republican. However, 22 to 29 year olds leaned Democrat. That they leaned D less strongly than younger voters leaned R is offset by the fact that there are roughly twice as many in the latter category. So essentially, it is a split, according to this one poll.

If everyone that should be in college were to flood vocational schools, you'd have no one to buy their services, and a S&D curve that will disfavor wage growth. My wages are significantly higher than people in the trades. Coincidentally, I went to a school focused on STEM with ~80% male students, so not sure how appealing that was for women then. In my own field, I can say it has been extremely unappealing for women for the most part. Not sure how men were made to feel uncomfortable when I was an undergrad, or how that has changed today, as I regularly visit campus. And given the love affair big schools have with all things sports, I fail to see how bro culture is being eliminated on campus.

I went to college and AI will never replace me. Unless you think AI will be capable of designing scientific experiments or handling the complexities of what goes wrong in a research environment. Anecdotal, but applicable to the whole of science. I'd say trust me because I've had the fortune of having had a broad scientific career ranging from clean rooms and high-performance microscopy to clinical trials, with time at national labs, universities, non-profits, and the private sector. And you can't offshore me easily b/c the only people with my skillset are in places where it is just as expensive to employ them as it is to employ me in the US.

Colleges aren't left-wing echo chambers so much as places where people learn how to analyze facts and expand their worldview through the myriad life experiences of students from all over the world. This experience in aggregate has a net impact on people that tends to leave them less conservative. You, implicit in your choice of words and coded phrases, believe that we should make it so that the output of college is a more even divide between liberal and conservative. But de facto that would be conservative indoctrination in order to achieve that, as the historical trend has always been towards more progressive beliefs and attitudes in the more educated.

I read it as 4.5 didn't end up performing as well as hoped in the real world and 4.1 being a direct iteration of 4o rather than 4.5.

They're operating with parallel code lines because each is targeting different use cases.

Yawn. Boring take. The people that voted Democrat in the 50s and 60s to perpetuate Jim Crow have voted Republican since the late 60s. GTFO with that weakass bullshit.