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Comment Re:Morbo Voice: (Score 1) 180

Even if the AC would have infinite efficiency (instead of typical values of 2-3), you are increasing temperature out-of-the-house by reducing temperature in-house

So then, you can just shut off your AC and just have it permanently cooler inside, right?

Wait, no you can't?

That's right, because heat leaks back into the house from the outside - warming your house, and cooling the exterior. And the amount it cools the exterior is approximately equal to the amount you're pumping out. Only the energy used by the AC is actually changing the outdoor temperature. But it's utterly dwarfed by the impact of the sun.

(I stress "approximately because there's some slight radiative balance changes - the heat outflow is a point source while the inflows are diffuse, and thermal radiation is proportional to the temperature to the fourth power - but it remains a trivial factor in practice)

Comment Re:Wait, what? (Score 1) 180

Physically, we're non-continental. There is no "continental shelf" here. We're not on continental crust. We're a part of the Mid-Atlantic ridge, the Atlantic seafloor, that protrudes above sea level. We're MORB, not granitic crust. Tectonic plates != continents. The North American plate for example contains large amounts of both continental and oceanic crust.

And yes, geopolitically, we're entirely European.

Comment Re:But, but!! (Score 1) 71

"Yep, so much Californian money goes to supporting the inefficient red states. It's little wonder."

Seriously? That's your "go to"?

Just... wow.

CA is exhausted as being the 5th largest economy in the world if it were it's own country, yet we have the highest taxes in virtually every single catagory, among the highest unemployment, poverty, homelessness, lowest ranked student performance (most high schools in CA are opting out of the federal standard tests now) -- virtually every category such a "wealthy" state should do well.

Shall we talk about how CA went from bragging about surpluses to huge deficits at the drop of a hat? While bringing in record breaking state revenue? All these problems are NOT due to federal taxes but California's poor management and apathetic electorate. And, "oh". Federal taxes are collected from the people of CA -- not what CA deigns to provide to the fed.

BTW, I'm not a republican -- and I'm a "never trumper" (proud to have had the opportunity to *NOT* vote for him 6 times (3 primaries and 3 national elections).

Jeez...

Comment Re:Wait, what? (Score 1) 180

** Of the places I've visited on the mainland. Ireland, England, Scotland, Holland, Germany, Austria, Czechia... wait, I do remember that my hotel in Paris didn't have AC, and I was utterly miserable there. Czechia and Austria were in the winter / early spring so one wouldn't notice. But I'd think I'd remember if the others had it or didn't...

Comment Morbo Voice: (Score 4, Informative) 180

French Energy Minister Agnes Pannier-Runacher countered that large-scale air conditioning would heat streets with exhaust, worsening heat waves.

"HEAT FLOW DOES NOT WORK THAT WAY!"

(For anyone who's unclear: all the heat that you're pumping out of houses is basically perfectly offbalanced by the heat penetrating into them. Only the energy to run the AC creates new heat, same as running any electrical appliance, but vs. the sun which - when overhead on a clear day - deposits about 1kW of energy per square meter, it's an utter irrelevance)

Comment A reminder that... (Score 1) 34

just because you "got over" a disease, it doesn't mean you're "better". Not all damage just goes away. It seems every month brings a new discovery about some disease is brought about or greatly increased in likelihood from past infection. For example, my mother suffers greatly from Sjögren's (incl. neuropathy where it feels like her skin is on fire). There's now increasing evidence pointing to it and related diseases as being at least in part triggered by Epstein-Barr, and my mother has strong diagnostic indicators of EBV reactivation. Even Alzheimers' research is pointing at past infection (combined with genetic susceptibility) as being a potential case, as amyloid beta and tau appear to be part of the brain's innate immune system, with accumulation as a result of inflammatory processes in the CNS.

"What doesn't kill you makes you stronger" is frankly nonsense. What doesn't kill you can leave you crippled, brain-damaged, with cancer, or any number of other things. Sequelae and postviral illnesses aren't some sort of a joke. I think one of the main lessons of COVID is to take sequelae and postviral illnesses in general more seriously - COVID brought them to attention because so many people got sick from a new virus at once, many severely ill (vs. say influenza, where only 5-15% contract it per year, and more often mild cases), but in no way is COVID unique to causing sequelae and postviral illnesses.

Comment Re: Covid-19 infection affects small blood vessels (Score 2) 34

I'll personally never get over how surprised people are to hear that COVID affects the cardiovascular system. The spike protein literally targets ACE2. That's its point of entry. ACE2 is a blood-pressure regulatory surface protein (Angiotensin-Converting Enzyme 2 - angiotensin is a vasoconstrictor), expressed by cells that need to modulate the cardiovascular system. Pulmonary-related deaths were the #1 cause of death from COVID, but cardiovascular-related deaths were #2 or #3 (depending on whether you count respiratory or multi-organ failure in the same category), not a trivial fraction, and with much greater potential for having been missed (as the pulmonary-related conditions were so characteristic and readily diagnosed, as well as being so much better known). Corresponding with the clinical data from known COVID cases, general-case cardiovascular deaths also spiked during COVID waves.

It's IMHO quite the irony that all the antivaxxers were freaking out about typically mild myocarditis from vaccines when COVID itself causes a much more severe myocarditis progression, much more often, and that's just a lesser one of its many cardiovascular complications.

Comment Re: Covid-19 infection affects small blood vessels (Score 1) 34

A quick AI-deepsearch doublecheck suggests that this isn't at all pseudoscience, so care you defend your argument?

An analysis of scientific and medical research largely supports the provided statement, with some nuances. Here's a breakdown of the fact-checked claims:

Heparin Use in Severe COVID-19

The statement claims that heparin, a blood thinner, was used for more severe Covid-19 infections because the smallest arteries, including those in the brain, tended to become clogged.

This is largely accurate. Severe COVID-19 is associated with hypercoagulability, a state of increased tendency for blood clotting[1]. This led to a higher incidence of thrombotic events, or blood clots[1][2]. As a result, anticoagulants like heparin were recommended for hospitalized patients to prevent and treat these clots[2][3][4]. Studies have shown that heparin can improve outcomes for severely ill COVID-19 patients, particularly those with high D-dimer levels, which is a marker for blood clotting[1][5]. While the statement's wording "clogged with products of the virus' effects" is a simplification, the core idea that heparin was used to combat blood clots in severe COVID-19 is correct.

COVID-19's Effect on Small Blood Vessels in the Brain

The statement posits that COVID-19 affects small blood vessels in the brain.

This is well-supported by evidence. Research indicates that COVID-19 can cause damage to the brain's small blood vessels[6][7][8]. Studies have shown evidence of inflammation and damage to the walls of these vessels, leading to leakage of proteins like fibrinogen into the brain[6][8]. This microvascular injury is considered a likely cause of neurological symptoms associated with COVID-19, such as "brain fog" and cognitive issues[6][7]. Some studies suggest this damage is a result of the body's inflammatory response to the virus rather than the virus directly infecting the brain's nerve cells[8].

Gender Differences in Blood Vessel Problems

The statement asserts that blood vessel problems are more common in males.

This is a more complex issue with some supporting evidence. Generally, men are at a greater risk for cardiovascular diseases, including atherosclerosis (hardening of the arteries) and high blood pressure, for a significant portion of their lives[9]. However, after menopause, the incidence of cardiovascular disease in women increases and can even out[9]. Some research also suggests that women's blood vessels may age faster than men's[10][11]. Furthermore, women are more likely to develop blockages in the heart's smallest blood vessels, while men tend to have them in the largest arteries[12]. Therefore, while there are gender differences, the claim that blood vessel problems are broadly "more common in males" is a simplification of a nuanced biological reality.

Arterial Disease as a Risk Factor for Brain "Aging" and Dementia

The statement claims that arterial blood vessel disease is a known risk factor for brain "aging," cognitive impairment, and dementia.

This is well-established. Vascular pathology is a significant contributor to age-related dementia[13][14]. Conditions like arterial stiffness and atherosclerosis are considered risk factors for cerebrovascular disease and dementia[13][15]. The health of blood vessels is crucial for brain function, and impairments in blood flow can lead to cognitive decline[14][16]. The link is so strong that controlling vascular risk factors is considered a key strategy in mitigating the impact of Alzheimer's disease and related dementias[13][14].

The Hypothesis: COVID-19's "Aging" Effects on the Brain are Mediated by Small Blood Vessel Effects

The statement concludes with the hypothesis that the "aging" effects of Covid-19 on the brain are mediated by the virus's impact on small blood vessels.

This is a plausible and actively researched hypothesis. Studies have shown that severe COVID-19 can induce molecular signatures of aging in the human brain[17]. Furthermore, research has demonstrated that the pandemic itself, even without infection, may have accelerated brain aging[18][19][20]. Given the known damage to small blood vessels in the brain caused by COVID-19 and the established link between vascular health and brain aging, it is a logical conclusion that the virus's impact on these vessels contributes to the observed accelerated brain aging and cognitive decline. Research points to neurovascular injury and inflammation as key mechanisms of COVID-19's effect on the brain[21][22].

Sources
help
nih.gov
scispace.com
mdpi.com
mdpi.com
nih.gov
defense.gov
sciencealert.com
drugtargetreview.com
cas.cz
vascular.org
news-medical.net
brighamandwomens.org
jacc.org
nih.gov
alzheimers.net
aginganddisease.org
nih.gov
time.com
nottingham.ac.uk
dw.com
news-medical.net
nih.gov

Comment Re:Hopefully (Score 1) 72

Offline backups are of course a very good thing, but even some simple things would greatly reduce your need to ever have to use them. For example, having your fileserver use a snapshotting filesystem and not run any remote-access tools (such as SSH), so snapshots can only be deleted in-person. Unless the hacker has a zero-day exploit for e.g. NFS or the server's operating system, that's a pretty safe setup.

Again, you still want offline (and off-site!) backups on top of that, but that's really something that you never want to have to resort to.

IMHO, we could basically reduce ransomware to near-zero if motherboards shipped with a fully-independent on-board snapshotting fileserver (with its own (minimal) compute hardware/memory, and with a physical button to switch between administering the filesystem and the main OS), and the main OS just mounted drives from the on-board fileserver. The best an attacker could do would be to fill up your drives in hopes that you'll just delete snapshots without checking why it's filled up, or to try to social engineer you into doing so.

Comment Re:But, but!! (Score 1) 71

That's been going on for ages. Used to be able to hit some of the sketchy parks and buy $100 worth of food stamps for $40. Buyer gets a huge savings on this weeks groceries and the addict gets another 2ish weeks of feeding their addiction.

EBT ATM cards kind of killed that market. Now they get full value on wasting their benefits.

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