22 Vaccines from Birth to 15 months alone. You are so 100% sure that 22 schedule is safe and effective? Without Proof or even evidence? That is sciency, not science.
If you have proper statistics, you should be able to draw some pretty solid epidemiological conclusions from them, even without a double-blind study. Different age cohorts will get a different vaccine schedule because, as you note, it changes over time. You can also run comparisons against other countries with different vaccination schedules. So far, I don't see any evidence that anything troubling is going on, but maybe you have something interesting to share?
This sounds a lot like the "cell phones cause cancer" stuff. No, there has never been a specific double-blind study to test it, but there's tons of aggregate data, and it looks to me like we've had to torture the data pretty hard to get a positive result, so I'm pretty satisfied that I don't need to worry too much.