Comment A slightly easier way to diet to a longer life (Score 3, Interesting) 66
From TFA:
By studying the mitochondria from cow heart cells, the researchers found that -KG blocks ATP synthase, thus turning down the cell’s metabolism.
Funny. You know what happens when you turn a cell's metabolism? It burns few calories. If you don't reduce calorie intake you get fat and suffer from a variety of obesity related illness that might kill you earlier than if you had not started taking the medication.
So in exchange for a possibly longer life you get to eat little and do little. Surprise, surprise! That is just like Calorie Restriction, albeit without the consistency requirement. That means you might actually achieve some benefit for the sacrifice rather than making the sacrifice, not getting it quite right, and getting no benefit.
Still, this doesn't sound like the fountain of youth. More like a prolonged living death.