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Comment Re:"Risks of clinical errors" (Score 1) 79

Wow. That's quite a story. I've posted this similar story below. I've stuck with this GP. I spent a bit of cardiac muscle training him. :-)


--
A few years ago, I presented to my GP - a skilled one - with sharp chest pain as a 43 year old with a history high BP and cholesterol. I met him alone. I asked him if it could be a heart attack. He said no. He diagnosed indigestion (even though I've never had indigestion in my life) and sent me home. He didn't go an ECG or a Troponin test (sometimes called a Troponin-T test, this is a blood test that dianoses ezymes released during a heart attack, when heart muscle is injured during a heart attack). He told me to keep taking my BP meds or I'd have a heart attack in 5 years.

I was likely already having a heart attack. :-)

A few hours later at night, when my condition didn't change, I drove to the ER where the hospital did an ECG and Troponin test. There, I got diagnosed with an ongoing heart attack and had a stent implanted immediately.

When I spoke to my GP afterward, he didn't consider heart disease because of my age, and because he'd be stuck there forever if he did an ECG and Troponin-T test with everyone with chest pain. When I spoke to the medical center's pathology nurse about this later, she was horrified the GP had done this. She said to come to her and she'd do an ECG and Troponin-T test if this reoccurred.

Which is a long-winded way to say this: you need second opinions. You ALWAYS need second opinions. A pathology nurse proferred a second opinion.

I think a doctor's notes and verbal discussion should be IMMEDIATELY relayed - as they are being made - to your own AI (or ChatGPT subscription). The AI should then have a chance to IMMEDIATELY second-guess the doctor's findings, and relay additional concerns to the doctor and to you. It would be like having a medically-informed layman accompanying you on your consultation.

Comment Hmmm... good, but not enough. Use your own AI (Score 1) 79

A few years ago, I presented to my GP - a skilled one - with sharp chest pain as a 43 year old with a history high BP and cholesterol. I met him alone. I asked him if it could be a heart attack. He said no. He diagnosed indigestion (even though I've never had indigestion in my life) and sent me home. He didn't go an ECG or a Troponin test (sometimes called a Troponin-T test, this is a blood test that dianoses ezymes released during a heart attack, when heart muscle is injured during a heart attack). He told me to keep taking my BP meds or I'd have a heart attack in 5 years.

I was likely already having a heart attack. :-)

A few hours later at night, when my condition didn't change, I drove to the ER where the hospital did an ECG and Troponin test. There, I got diagnosed with an ongoing heart attack and had a stent implanted immediately.

When I spoke to my GP afterward, he didn't consider heart disease because of my age, and because he'd be stuck there forever if he did an ECG and Troponin-T test with everyone with chest pain. When I spoke to the medical center's pathology nurse about this later, she was horrified the GP had done this. She said to come to her and she'd do an ECG and Troponin-T test if this reoccurred.

Which is a long-winded way to say this: you need second opinions. You ALWAYS need second opinions. A pathology nurse proferred a second opinion.

I think a doctor's notes and verbal discussion should be IMMEDIATELY relayed - as they are being made - to your own AI (or ChatGPT subscription). The AI should then have a chance to IMMEDIATELY second-guess the doctor's findings, and relay additional concerns to the doctor and to you. It would be like having a medically-informed layman accompanying you on your consultation.

Comment Re:How do data leaks work? (Score 1) 32

You are correct. Donald Knuth, the famous computer scientist, himself says LLMs generate excellent "copy".
One day, exchanging (polite) message with obvious typos and unexpected turns of grammar and side-musings will be seen as a sign of genuine affection between humans communicating. :)

Comment Re:AI/LLMs and language translation (Score 1) 100

Thank you ... Interesting

Looks like we need TIOBE to be like a Neilsen Ratings TV set top box that measures what people actually watch. But in reality, it's more like something that counts up TV schedule listings.

TIOBE should offer a free 'anonymous stats reporting' plugin to various IDEs (Visual Studio, Eclipse, IntelliJ, Emacs, vim)

Comment Re:AI/LLMs and language translation (Score 1) 100

Interesting.
  I have not used modern IDEs for several years
But a few months ago, I used AI LLM portals (Claude, ChatGPT) to code up a new 1000 line program in an unfamiliar language (Excel VBA). That was a 'copy paste compile debug repeat' exercise in creating a new program.. Given LLM session memory constraints, I could not imagine doing that to study and modify a complex existing codebase (say, a 100 KSLoC Java application).

What tool do you think could work ?

Comment Re:Cooling is easier in a vaccum?? (Score 1) 90

You're right about radiative cooling - I didn't consider that radiative cooling would be that much easier.

I asked claude.ai a bunch of questions.below According to it, purely radiative cooling of a device in space (40-60C) is roughly as effective as very crude conductive cooling of a similar device on earth (internal temp 49 C).

_---------_
Consider a 1 m radius spherical object in LEO. One direction, bathed in direct sunlight is coated with solar panels. The electricity generated runs computers internally - the computers are capable of running regardless of the internal temperature of the enclosure. The reverse side is exposed to the 2.7 K of the CMB and had small metal radiative panels.

Compare it to another similar size sphere stored in a room at a constant 22C on earth. Instead of solar panels, the same amount of electricity is pumped in.

In which case would the internal temperature of the sphere be higher?
Make a few assumptions about the other parameters. All power generated by the solar panels in space, or fed in by power lines on earth is immediately used for computation.

Give me rough internal temperatures for both cases

Now assume the sphere on earth is (a) suspended on a thread (b) half buried (c) fully buried , and it has a metal body.
--------------

Answers from Clause.ai
LEO. 40-60 C
Earth.a 95 C
Earth.b 75 C
Earth.c 49 C

Comment AI/LLMs and language translation (Score 4, Interesting) 100

As time goes by, I hope programming editors and IDEs start doing language translation via AI.

Say, someone needs to edit a C program but is not very skilled in it. They could use their favourite language (say, C#), to quasi-edit the source program (which would be presented as C# to them). C# code changes would be auto-translated to C in a manner that fits the source codebase's conventions. Aspects of the C program that have no C# equivalent could summarised and edited by AI dialog.

I wonder how TIOBE would measure this sort of work. As activity in the source language (C)? Editing language (C#)? Or both?

Comment Re:Lupus and Scleroderma in the same family (Score 1) 49

This news says all lupus cases may be caused by the EBV virus. Link:
https://www.nbcnews.com/health...
The Epstein-Barr virus was found to reprogram immune B cells to wrongly attack the nucleii of other cells with 'anti-nuclear antibodies'

Past research has also liked scleroderma and EBV. So I feel lupus and scleroderma may both have be triggered by EBV.
  EBV hides in immune B cells. This has also been linked to scleroderma. So the question is how to flush out these bad cells, called *auto-reactive B cells*.

Some more ideas:

_-----_
- Could a blood transfusion help? I am O+ ... Universal donor. Just kidding.. I am rolling my sleeves just yet. But worth investigating with the help of AI and doctors. Remember, Leviticus 17:11 states, "For the life of the flesh is in the blood...".

- There is also a treatment called autopheresis. It seperates out blood into its various components (plasma, platelets) and returns the desired components back to you. Perhaps B cells count can be reduced this way.

- Photopheresis. This is an immune-modulating treatment. Here your immune blood cells are separated and exposed to UVA light. It is used for scleroderma to help with skin thickening, joint involvement, and other symptoms, particularly in patients with refractory disease.

- UVA1 phototherapy. This is a topical, non invasive treatment that involves shining the UVA1 band of ultraviolet light, which is longer than UVA and penetrates deeper. UVA1 phototherapy can lead to softening and a reduction of sclerotic plaques, with benefits such as increased skin elasticity and a reduction in skin thickness

- Rituximab: This is a well-studied antibody therapy that eliminates B cells by binding to the CD20 protein on their surface. It has shown favorable results in many patients, including those with scleroderma and lupus resistant to other treatments.

- CAR T-cell therapy: This cutting-edge approach modifies a patient's own T-cells to specifically target and destroy auto-reactive B cells.

- Reduction of unhealthy immune b cells in blood by infusion of cultured healthy autologous b cells (your own B cells) That's so the good B cells crowd out the bad ones. This may be done in combination with either autopheresis, apheresis, transfusion of other blood fractions and simple blood-letting (phelobotomy)

- Autologous Hematopoietic Stem Cell Transplantation (AHSCT). AHSCT is a more intensive treatment that first uses high-dose immunosuppression to wipe out the existing, dysfunctional immune cells, including B cells. The patient's own (autologous) stem cells are then transplanted to rebuild a new, healthier immune system that is re-established as self-tolerant.

- Natural killer (NK) cells play a crucial role in the immune system's defense against Epstein-Barr virus (EBV) by targeting and eliminating EBV-infected B cells. Food to boost NK cells include mushroom, garlic, turmeric, and green tea. [Mushrooms]: Varieties like shiitake and maitake contain beta-glucans, compounds that have been shown to stimulate NK cell activity in studies. [Garlic]: Contains sulfur compounds like allicin that can stimulate various immune cells, including NK cells. [Turmeric]: The active ingredient, curcumin, has anti-inflammatory properties and can enhance NK cell function. [Green Tea]: Rich in the antioxidant EGCG, which may stimulate NK cell activity.

- light exposure - you need vitamin D, but high intensity sunlight exposure can worsen scleroderma flares. So some amount of daily sun exposure (to be quantified; perhaps early mornings) and this light therapy called UVB-NB (narrowband UVB) shows promise for scleroderma. https://www.odermatol.com/oder...

- Vitamins D. scleroderma patients typically need high-dose vitamin D3 (cholecalciferol) due to high deficiency rates and potential malabsorption. To ensure effective use and prevent soft tissue calcification, cofactors like magnesium and vitamin K2 are generally recommended, while zinc and boron may also be beneficial due to common deficiencies and their role in immune function. Regular monitoring of serum vitamin D, calcium, and PTH levels is essential to achieve a target range

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